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Stammers DK

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Publications:

Title Authors Year Journal
Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors. Stammers DK 2008 J Med Chem
Evolution of a novel 5-amino-acid insertion in the beta3-beta4 loop of HIV-1 reverse transcriptase. Stammers DK 2007 Virology
Relationship of potency and resilience to drug resistant mutations for GW420867X revealed by crystal structures of inhibitor complexes for wild-type, Leu100Ile, Lys101Glu, and Tyr188Cys mutant HIV-1 reverse transcriptases. Stammers DK 2007 J Med Chem
Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138. Stammers DK 2006 FEBS J
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2. Stammers DK 2004 J Med Chem
The phenylmethylthiazolylthiourea nonnucleoside reverse transcriptase (RT) inhibitor MSK-076 selects for a resistance mutation in the active site of human immunodeficiency virus type 2 RT. Stammers DK 2004 Journal of virology
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1. Stammers DK 2004 J Med Chem
Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors. Stammers DK 2004 Journal of molecular biology
Cloning, expression, purification, and crystallisation of HIV-2 reverse transcriptase. Stammers DK 2003 Protein expression and purification
Structure of HIV-2 reverse transcriptase at 2.35-A resolution and the mechanism of resistance to non-nucleoside inhibitors. Stammers DK 2002 Proceedings of the National Academy of Sciences of the United States of America
Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215. Stammers DK 2002 J Virol
A mutation in the 3' region of the human immunodeficiency virus type 1 reverse transcriptase (Y318F) associated with nonnucleoside reverse transcriptase inhibitor resistance. Stammers DK 2002 Journal of virology
Correlation between viral resistance to zidovudine and resistance at the reverse transcriptase level for a panel of human immunodeficiency virus type 1 mutants. Stammers DK 2001 J Virol
2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. Stammers DK 2001 J Med Chem
Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors. Stammers DK 2001 Journal of molecular biology
Binding of the second generation non-nucleoside inhibitor S-1153 to HIV-1 reverse transcriptase involves extensive main chain hydrogen bonding. Stammers DK 2000 The Journal of biological chemistry
Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases. Structural and biochemical analyses. Stammers DK 2000 The Journal of biological chemistry
Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase. Stammers DK 2000 Structure (London, England : 1993)
Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants. Stammers DK 1999 J Med Chem
Crystallographic analysis of the binding modes of thiazoloisoindolinone non-nucleoside inhibitors to HIV-1 reverse transcriptase and comparison with modeling studies. Stammers DK 1999 J Med Chem
A family of insertion mutations between codons 67 and 70 of human immunodeficiency virus type 1 reverse transcriptase confer multinucleoside analog resistance. Stammers DK 1999 Antimicrob Agents Chemother
Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives. Stammers DK 1998 Biochemistry
3'-Azido-3'-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes. Stammers DK 1998 Proceedings of the National Academy of Sciences of the United States of America
Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor. Stammers DK 1997 Proceedings of the National Academy of Sciences of the United States of America
Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors. Stammers DK 1996 J Med Chem

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