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Ren J

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Publications:

Title Authors Year Journal
Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors. Ren J 2008 J Med Chem
Relationship of potency and resilience to drug resistant mutations for GW420867X revealed by crystal structures of inhibitor complexes for wild-type, Leu100Ile, Lys101Glu, and Tyr188Cys mutant HIV-1 reverse transcriptases. Ren J 2007 J Med Chem
Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138. Ren J 2006 FEBS J
Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors. Ren J 2004 Journal of molecular biology
The phenylmethylthiazolylthiourea nonnucleoside reverse transcriptase (RT) inhibitor MSK-076 selects for a resistance mutation in the active site of human immunodeficiency virus type 2 RT. Ren J 2004 Journal of virology
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1. Ren J 2004 J Med Chem
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2. Ren J 2004 J Med Chem
Cloning, expression, purification, and crystallisation of HIV-2 reverse transcriptase. Ren J 2003 Protein expression and purification
Structure of HIV-2 reverse transcriptase at 2.35-A resolution and the mechanism of resistance to non-nucleoside inhibitors. Ren J 2002 Proceedings of the National Academy of Sciences of the United States of America
Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215. Ren J 2002 J Virol
2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. Ren J 2001 J Med Chem
Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors. Ren J 2001 Journal of molecular biology
Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases. Structural and biochemical analyses. Ren J 2000 The Journal of biological chemistry
Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase. Ren J 2000 Structure (London, England : 1993)
Binding of the second generation non-nucleoside inhibitor S-1153 to HIV-1 reverse transcriptase involves extensive main chain hydrogen bonding. Ren J 2000 The Journal of biological chemistry
A family of insertion mutations between codons 67 and 70 of human immunodeficiency virus type 1 reverse transcriptase confer multinucleoside analog resistance. Ren J 1999 Antimicrob Agents Chemother
Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants. Ren J 1999 J Med Chem
Crystallographic analysis of the binding modes of thiazoloisoindolinone non-nucleoside inhibitors to HIV-1 reverse transcriptase and comparison with modeling studies. Ren J 1999 J Med Chem
3'-Azido-3'-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes. Ren J 1998 Proceedings of the National Academy of Sciences of the United States of America
Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives. Ren J 1998 Biochemistry
Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor. Ren J 1997 Proceedings of the National Academy of Sciences of the United States of America
Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors. Ren J 1996 J Med Chem
Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors. Ren J 1995 Nat Struct Biol
High resolution structures of HIV-1 RT from four RT-inhibitor complexes. Ren J 1995 Nat Struct Biol
The structure of HIV-1 reverse transcriptase complexed with 9-chloro-TIBO: lessons for inhibitor design. Ren J 1995 Structure (London, England : 1993)

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