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Mitsuya H

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Publications:

Title Authors Year Journal
Effects of 4' - and 2-Substitutions on the Bioactivity of 4' -Ethynyl-2-Fluoro-2' -Deoxyadenosine. Mitsuya H 2013 Antimicrobial agents and chemotherapy
Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA. Mitsuya H 2013 Retrovirology
Balancing Antiviral Potency and Host Toxicity: Identifying a Nucleotide Inhibitor with an Optimal Kinetic Phenotype for HIV-1 Reverse Transcriptase. Mitsuya H 2012 Molecular pharmacology
Effect of translocation defective reverse transcriptase inhibitors on the activity of n348i, a connection subdomain drug resistant hiv-1 reverse transcriptase mutant. Mitsuya H 2012 Cellular and molecular biology (Noisy-le-Grand, France)
Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase. Mitsuya H 2011 Nucleic acids research
The Mechanism of Interaction of Human Mitochondrial DNA Polymerase γ with the Novel Nucleoside Reverse Transcriptase Inhibitor 4' -Ethynyl-2-Fluoro-2' -Deoxyadenosine Indicates a Low Potential for Host Toxicity. Mitsuya H 2011 Antimicrobial agents and chemotherapy
The sugar ring conformation of 4'-ethynyl-2-fluoro-2'-deoxyadenosine and its recognition by the polymerase active site of HIV reverse transcriptase. Mitsuya H 2011 Cellular and molecular biology (Noisy-le-Grand, France)
2'-deoxy-4'-C-ethynyl-2-halo-adenosines active against drug-resistant human immunodeficiency virus type 1 variants. Mitsuya H 2008 The international journal of biochemistry & cell biology
Activity against human immunodeficiency virus type 1, intracellular metabolism, and effects on human DNA polymerases of 4'-ethynyl-2-fluoro-2'-deoxyadenosine. Mitsuya H 2007 Antimicrob Agents Chemother
2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine: a nucleoside reverse transcriptase inhibitor with highly potent activity against all HIV-1 strains, favorable toxic profiles and stability in plasma. Mitsuya H 2006 Nucleic Acids Symp Ser (Oxf)
Design, efficient synthesis, and anti-HIV activity of 4'-C-cyano- and 4'-C-ethynyl-2'-deoxy purine nucleosides. Mitsuya H 2004 Nucleosides, nucleotides & nucleic acids
A 4'-C-ethynyl-2',3'-dideoxynucleoside analogue highlights the role of the 3'-OH in anti-HIV active 4'-C-ethynyl-2'-deoxy nucleosides. Mitsuya H 2004 J Med Chem
Attempt to reduce cytotoxicity by synthesizing the L-enantiomer of 4'-C-ethynyl-2'-deoxypurine nucleosides as antiviral agents against HIV and HBV. Mitsuya H 2004 Antivir Chem Chemother
A conformationally locked analogue of the anti-HIV agent stavudine. An important correlation between pseudorotation and maximum amplitude. Mitsuya H 2003 Journal of medicinal chemistry
4'-Ethynyl nucleoside analogs: potent inhibitors of multidrug-resistant human immunodeficiency virus variants in vitro. Mitsuya H 2001 Antimicrob Agents Chemother
4'-C-substituted-2'-deoxynucleosides: a family of antiretroviral agents which are potent against drug-resistant HIV variants. Mitsuya H 2001 Curr Drug Targets Infect Disord
Interactions of conformationally biased north and south 2'-fluoro-2', 3'-dideoxynucleoside 5'-triphosphates with the active site of HIV-1 reverse transcriptase. Mitsuya H 2000 Biochemistry
Differential influence of nucleoside analog-resistance mutations K65R and L74V on the overall mutation rate and error specificity of human immunodeficiency virus type 1 reverse transcriptase. Mitsuya H 2000 The Journal of biological chemistry
In vitro induction of human immunodeficiency virus type 1 variants resistant to phosphoralaninate prodrugs of Z-methylenecyclopropane nucleoside analogues. Mitsuya H 1999 Antimicrobial agents and chemotherapy
Altered drug sensitivity, fitness, and evolution of human immunodeficiency virus type 1 with pol gene mutations conferring multi-dideoxynucleoside resistance. Mitsuya H 1998 J Infect Dis
In vitro induction of human immunodeficiency virus type 1 variants resistant to 2'-beta-Fluoro-2',3'-dideoxyadenosine. Mitsuya H 1997 Antimicrobial agents and chemotherapy
Comparative enzymatic study of HIV-1 reverse transcriptase resistant to 2',3'-dideoxynucleotide analogs using the single-nucleotide incorporation assay. Mitsuya H 1997 Biochemistry
In vitro selection and molecular characterization of human immunodeficiency virus type 1 with reduced sensitivity to 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). Mitsuya H 1996 Antiviral research
Enzymatic characterization of human immunodeficiency virus type 1 reverse transcriptase resistant to multiple 2',3'-dideoxynucleoside 5'-triphosphates. Mitsuya H 1995 The Journal of biological chemistry
Long-term inhibition of human T-lymphotropic virus type III/lymphadenopathy-associated virus (human immunodeficiency virus) DNA synthesis and RNA expression in T cells protected by 2',3'-dideoxynucleosides in vitro. Mitsuya H 1987 Proceedings of the National Academy of Sciences of the United States of America
Comparative inhibitory effects of suramin and other selected compounds on the infectivity and replication of human T-cell lymphotropic virus (HTLV-III)/lymphadenopathy-associated virus (LAV). Mitsuya H 1986 International journal of cancer. Journal international du cancer
Aurintricarboxylic acid and Evans Blue represent two different classes of anionic compounds which selectively inhibit the cytopathogenicity of human T-cell lymphotropic virus type III/lymphadenopathy-associated virus. Mitsuya H 1986 Biochemical and biophysical research communications

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