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de Vega M

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Publications:

Title Authors Year Journal
Dual Role of φ29 DNA Polymerase Lys529 in Stabilisation of the DNA Priming-Terminus and the Terminal Protein-Priming Residue at the Polymerisation Site. de Vega M 2013 PloS one
DNA stabilization at the Bacillus subtilis PolX core--a binding model to coordinate polymerase, AP-endonuclease and 3'-5' exonuclease activities. de Vega M 2012 Nucleic acids research
The essential role of the 3' terminal template base in the first steps of protein-primed DNA replication. de Vega M 2012 PloS one
Involvement of residues of the 29 terminal protein intermediate and priming domains in the formation of a stable and functional heterodimer with the replicative DNA polymerase. de Vega M 2011 Nucleic acids research
Terminal protein-primed amplification of heterologous DNA with a minimal replication system based on phage {Phi}29. de Vega M 2011 Proceedings of the National Academy of Sciences of the United States of America
phi29 DNA polymerase active site: role of residue Val250 as metal-dNTP complex ligand and in protein-primed initiation. de Vega M 2010 Journal of molecular biology
Improvement of phi29 DNA polymerase amplification performance by fusion of DNA binding motifs. de Vega M 2010 Proceedings of the National Academy of Sciences of the United States of America
Intrinsic apurinic/apyrimidinic (AP) endonuclease activity enables Bacillus subtilis DNA polymerase X to recognize, incise, and further repair abasic sites. de Vega M 2010 Proceedings of the National Academy of Sciences of the United States of America
Functional importance of bacteriophage phi29 DNA polymerase residue Tyr148 in primer-terminus stabilisation at the 3'-5' exonuclease active site. de Vega M 2009 Journal of molecular biology
Involvement of the TPR2 subdomain movement in the activities of phi29 DNA polymerase. de Vega M 2009 Nucleic acids research
Enzymatic synthesis of structure-free DNA with pseudo-complementary properties. de Vega M 2008 Nucleic acids research
Editing of misaligned 3'-termini by an intrinsic 3'-5' exonuclease activity residing in the PHP domain of a family X DNA polymerase. de Vega M 2008 Nucleic acids research
Phage phi29 and Nf terminal protein-priming domain specifies the internal template nucleotide to initiate DNA replication. de Vega M 2008 Proceedings of the National Academy of Sciences of the United States of America
The bacteriophage phi29 DNA polymerase. de Vega M 2008 IUBMB Life
Characterization of a Bacillus subtilis 64-kDa DNA polymerase X potentially involved in DNA repair. de Vega M 2008 Journal of molecular biology
Involvement of phage phi29 DNA polymerase and terminal protein subdomains in conferring specificity during initiation of protein-primed DNA replication. de Vega M 2007 Nucleic acids research
Structures of phi29 DNA polymerase complexed with substrate: the mechanism of translocation in B-family polymerases. de Vega M 2007 The EMBO journal
A highly conserved Tyrosine residue of family B DNA polymerases contributes to dictate translesion synthesis past 8-oxo-7,8-dihydro-2'-deoxyguanosine. de Vega M 2007 Nucleic acids research
Involvement of phi29 DNA polymerase thumb subdomain in the proper coordination of synthesis and degradation during DNA replication. de Vega M 2006 Nucleic acids research
The phi29 DNA polymerase:protein-primer structure suggests a model for the initiation to elongation transition. de Vega M 2006 The EMBO journal
Functional characterization of highly processive protein-primed DNA polymerases from phages Nf and GA-1, endowed with a potent strand displacement capacity. de Vega M 2006 Nucleic acids research
Involvement of the "linker" region between the exonuclease and polymerization domains of phi29 DNA polymerase in DNA and TP binding. de Vega M 2005 Gene
A specific subdomain in phi29 DNA polymerase confers both processivity and strand-displacement capacity. de Vega M 2005 Proceedings of the National Academy of Sciences of the United States of America
Insights into strand displacement and processivity from the crystal structure of the protein-primed DNA polymerase of bacteriophage phi29. de Vega M 2004 Molecular cell
phi29 DNA polymerase-terminal protein interaction. Involvement of residues specifically conserved among protein-primed DNA polymerases. de Vega M 2004 Journal of molecular biology
phi 29 DNA polymerase residue Leu384, highly conserved in motif B of eukaryotic type DNA replicases, is involved in nucleotide insertion fidelity. de Vega M 2003 The Journal of biological chemistry
A conserved insertion in protein-primed DNA polymerases is involved in primer terminus stabilisation. de Vega M 2003 Journal of molecular biology
phi29 DNA polymerase residue Phe128 of the highly conserved (S/T)Lx(2)h motif is required for a stable and functional interaction with the terminal protein. de Vega M 2003 Journal of molecular biology
Phi29 DNA polymerase residues Tyr59, His61 and Phe69 of the highly conserved ExoII motif are essential for interaction with the terminal protein. de Vega M 2002 Nucleic acids research
Phage phi 29 DNA polymerase residues involved in the proper stabilisation of the primer-terminus at the 3'-5' exonuclease active site. de Vega M 2000 Journal of molecular biology
An aspartic acid residue in TPR-1, a specific region of protein-priming DNA polymerases, is required for the functional interaction with primer terminal protein. de Vega M 2000 Journal of molecular biology
Processive proofreading and the spatial relationship between polymerase and exonuclease active sites of bacteriophage phi29 DNA polymerase. de Vega M 1999 Journal of molecular biology
phi29 DNA polymerase residue Ser122, a single-stranded DNA ligand for 3'-5' exonucleolysis, is required to interact with the terminal protein. de Vega M 1998 The Journal of biological chemistry
Mutational analysis of phi29 DNA polymerase residues acting as ssDNA ligands for 3'-5' exonucleolysis. de Vega M 1998 Journal of molecular biology
An invariant lysine residue is involved in catalysis at the 3'-5' exonuclease active site of eukaryotic-type DNA polymerases. de Vega M 1997 Journal of molecular biology
Primer-terminus stabilization at the 3'-5' exonuclease active site of phi29 DNA polymerase. Involvement of two amino acid residues highly conserved in proofreading DNA polymerases. de Vega M 1996 The EMBO journal
Terminal protein-primed DNA amplification. de Vega M 1994 Proceedings of the National Academy of Sciences of the United States of America

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