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Eckert KA

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Publications:

Title Authors Year Journal
DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis. Eckert KA 2013 The Journal of cell biology
The human gastric cancer-associated DNA polymerase β variant D160N is a mutator that induces cellular transformation. Eckert KA 2012 DNA repair
Mechanism of Replicative DNA Polymerase Delta Pausing and a Potential Role for DNA Polymerase Kappa in Common Fragile Site Replication. Eckert KA 2012 Journal of molecular biology
The in vitro fidelity of yeast DNA polymerase δ and polymerase ε holoenzymes during dinucleotide microsatellite DNA synthesis. Eckert KA 2011 DNA repair
Incorporation of gemcitabine and cytarabine into DNA by DNA polymerase beta and ligase III/XRCC1. Eckert KA 2010 Biochemistry
DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D. Eckert KA 2010 Nucleic acids research
Loop II of DNA polymerase beta is important for discrimination during substrate binding. Eckert KA 2009 DNA repair
DNA polymerase kappa produces interrupted mutations and displays polar pausing within mononucleotide microsatellite sequences. Eckert KA 2008 Nucleic acids research
Escherichia coli DNA polymerase IV contributes to spontaneous mutagenesis at coding sequences but not microsatellite alleles. Eckert KA 2007 Mutation research
DNA polymerases and human diseases. Eckert KA 2006 Radiat Res
Prostate-cancer-associated I260M variant of DNA polymerase beta is a sequence-specific mutator. Eckert KA 2005 Biochemistry
Effect of DNA polymerase beta loop variants on discrimination of O6-methyldeoxyguanosine modification present in the nucleotide versus template substrate. Eckert KA 2005 Biochemistry
Threonine 79 is a hinge residue that governs the fidelity of DNA polymerase beta by helping to position the DNA within the active site. Eckert KA 2002 The Journal of biological chemistry
The proofreading 3'-->5' exonuclease activity of DNA polymerases: a kinetic barrier to translesion DNA synthesis. Eckert KA 2002 Mutation research
Misalignment-mediated DNA polymerase beta mutations: comparison of microsatellite and frame-shift error rates using a forward mutation assay. Eckert KA 2002 Biochemistry
Hydrophobic interactions in the hinge domain of DNA polymerase beta are important but not sufficient for maintaining fidelity of DNA synthesis. Eckert KA 2000 Biochemistry
DNA polymerase mutagenic bypass and proofreading of endogenous DNA lesions. Eckert KA 1999 Mutation research
The mutator form of polymerase beta with amino acid substitution at tyrosine 265 in the hinge region displays an increase in both base substitution and frame shift errors. Eckert KA 1998 Biochemistry
Base miscoding and strand misalignment errors by mutator Klenow polymerases with amino acid substitutions at tyrosine 766 in the O helix of the fingers subdomain. Eckert KA 1997 The Journal of biological chemistry
A genetic system to identify DNA polymerase beta mutator mutants. Eckert KA 1997 Proceedings of the National Academy of Sciences of the United States of America
Development and use of an in vitro HSV-tk forward mutation assay to study eukaryotic DNA polymerase processing of DNA alkyl lesions. Eckert KA 1997 Nucleic acids research
Fidelity of DNA synthesis catalyzed by human DNA polymerase alpha and HIV-1 reverse transcriptase: effect of reaction pH. Eckert KA 1993 Nucleic acids research
Effect of reaction pH on the fidelity and processivity of exonuclease-deficient Klenow polymerase. Eckert KA 1993 The Journal of biological chemistry
Biochemical studies on the reverse transcriptase and RNase H activities from human immunodeficiency virus strains resistant to 3'-azido-3'-deoxythymidine. Eckert KA 1992 The Journal of biological chemistry
DNA polymerase fidelity and the polymerase chain reaction. Eckert KA 1991 PCR Methods Appl
High fidelity DNA synthesis by the Thermus aquaticus DNA polymerase. Eckert KA 1990 Nucleic acids research

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