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Wang J

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Publications:

Title Authors Year Journal
Using a Fluorescent Cytosine Analogue tC(o) To Probe the Effect of the Y567 to Ala Substitution on the Preinsertion Steps of dNMP Incorporation by RB69 DNA Polymerase. Wang J 2012 Biochemistry
DNA Mismatch Synthesis Complexes Provide Insights into Base Selectivity of a B Family DNA Polymerase. Wang J 2012 Journal of the American Chemical Society
Structural Basis for Differential Insertion Kinetics of dNMPs Opposite a Difluorotoluene Nucleotide Residue. Wang J 2012 Biochemistry
Contribution of Partial Charge Interactions and Base-Stacking to the Efficiency of Primer-Extension at and beyond Abasic Sites in DNA. Wang J 2012 Biochemistry
Bidendate and tridendate metal-ion coordination states within ternary complexes of RB69 DNA polymerase. Wang J 2012 Protein science : a publication of the Protein Society
Structural Insights into Complete Metal Ion Coordination from Ternary Complexes of B Family RB69 DNA Polymerase. Wang J 2011 Biochemistry
Insights into Base Selectivity from the 1.8 A Resolution Structure of an RB69 DNA Polymerase Ternary Complex. Wang J 2011 Biochemistry
Hydrogen-bonding capability of a templating difluorotoluene nucleotide residue in an RB69 DNA polymerase ternary complex. Wang J 2011 Journal of the American Chemical Society
Variation in Mutation Rates Caused by RB69pol Fidelity Mutants Can Be Rationalized on the Basis of Their Kinetic Behavior and Crystal Structures. Wang J 2011 Journal of molecular biology
N1-Alkyl pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Wang J 2010 Bioorganic & medicinal chemistry letters
Substitution of Ala for Tyr567 in RB69 DNA polymerase allows dAMP to be inserted opposite 7,8-dihydro-8-oxoguanine . Wang J 2010 Biochemistry
Substitution of Ala for Tyr567 in RB69 DNA Polymerase Allows dAMP and dGMP To Be Inserted opposite Guanidinohydantoin . Wang J 2010 Biochemistry
N1-Heterocyclic pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Wang J 2010 Bioorganic & medicinal chemistry letters
Impact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile. Wang J 2009 Antimicrobial agents and chemotherapy
RB69 DNA polymerase mutants with expanded nascent base-pair-binding pockets are highly efficient but have reduced base selectivity. Wang J 2009 Biochemistry
DNA polymerase-catalyzed DNA network growth. Wang J 2008 Journal of the American Chemical Society
Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase by a stavudine analogue, 4'-ethynyl stavudine triphosphate. Wang J 2008 Antimicrobial agents and chemotherapy
Poleta, Polzeta and Rev1 together are required for G to T transversion mutations induced by the (+)- and (-)-trans-anti-BPDE-N2-dG DNA adducts in yeast cells. Wang J 2006 Nucleic acids research
The L561A substitution in the nascent base-pair binding pocket of RB69 DNA polymerase reduces base discrimination. Wang J 2006 Biochemistry
The phi29 DNA polymerase:protein-primer structure suggests a model for the initiation to elongation transition. Wang J 2006 The EMBO journal
A specific subdomain in phi29 DNA polymerase confers both processivity and strand-displacement capacity. Wang J 2005 Proceedings of the National Academy of Sciences of the United States of America
Base selectivity is impaired by mutants that perturb hydrogen bonding networks in the RB69 DNA polymerase active site. Wang J 2005 Biochemistry
Correction of X-ray intensities from single crystals containing lattice-translocation defects. Wang J 2005 Acta Crystallogr D Biol Crystallogr
Insights into strand displacement and processivity from the crystal structure of the protein-primed DNA polymerase of bacteriophage phi29. Wang J 2004 Molecular cell
The activity of selected RB69 DNA polymerase mutants can be restored by manganese ions: the existence of alternative metal ion ligands used during the polymerization cycle. Wang J 2004 Biochemistry
Pre-steady-state kinetics of RB69 DNA polymerase and its exo domain mutants: effect of pH and thiophosphoryl linkages on 3'-5' exonuclease activity. Wang J 2004 Biochemistry
Crystal structures of the Bacillus stearothermophilus CCA-adding enzyme and its complexes with ATP or CTP. Wang J 2002 Cell
Structure of the replicating complex of a pol alpha family DNA polymerase. Wang J 2001 Cell
Inhibition of HIV-1 replication by a Tat RNA-binding domain peptide analog. Wang J 1998 Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association
Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69. Wang J 1997 Cell
Crystal structures of an NH2-terminal fragment of T4 DNA polymerase and its complexes with single-stranded DNA and with divalent metal ions. Wang J 1996 Biochemistry
Structure of Taq polymerase with DNA at the polymerase active site. Wang J 1996 Nature
Crystal structure of Thermus aquaticus DNA polymerase. Wang J 1995 Nature
Structural basis of asymmetry in the human immunodeficiency virus type 1 reverse transcriptase heterodimer. Wang J 1994 Proceedings of the National Academy of Sciences of the United States of America
Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1. Wang J 1994 Proceedings of the National Academy of Sciences of the United States of America
Comparison of three different crystal forms shows HIV-1 reverse transcriptase displays an internal swivel motion. Wang J 1994 Structure (London, England : 1993)
Two DNA polymerases: HIV reverse transcriptase and the Klenow fragment of Escherichia coli DNA polymerase I. Wang J 1993 Cold Spring Harbor symposia on quantitative biology
Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor. Wang J 1992 Science
Role of DNA polymerase 3'----5' exonuclease activity in the bypass of aminofluorene lesions in DNA. Wang J 1990 Carcinogenesis
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