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Kaguni LS

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Publications:

Title Authors Year Journal
Muscle-specific overexpression of the catalytic subunit of DNA polymerase γ induces pupal lethality in Drosophila melanogaster. Kaguni LS 2013 Archives of insect biochemistry and physiology
Clustering of Alpers disease mutations and catalytic defects in biochemical variants reveal new features of molecular mechanism of the human mitochondrial replicase, Pol {gamma} Kaguni LS 2011 Nucleic acids research
Reduced stimulation of recombinant Pol {gamma} and mtDNA helicase by variants of mitochondrial single-stranded DNA-binding protein (mtSSB) correlates with defects in mtDNA Replication in animal cells. Kaguni LS 2011 The Journal of biological chemistry
Functional analysis of H. sapiens DNA polymerase gamma spacer mutation W748S with and without common variant E1143G. Kaguni LS 2010 Biochimica et biophysica acta
Parallel multiplicative target screening against divergent bacterial replicases: identification of specific inhibitors with broad spectrum potential. Kaguni LS 2010 Biochemistry
Disruption of mitochondrial DNA replication in Drosophila increases mitochondrial fast axonal transport in vivo. Kaguni LS 2009 PloS one
Comparative purification strategies for Drosophila and human mitochondrial DNA replication proteins: DNA polymerase gamma and mitochondrial single-stranded DNA-binding protein. Kaguni LS 2009 Methods in molecular biology (Clifton, N.J.)
Over-expression of the catalytic core of mitochondrial DNA (mtDNA) polymerase in the nervous system of Drosophila melanogaster reduces median life span by inducing mtDNA depletion. Kaguni LS 2008 Journal of neurochemistry
A novel processive mechanism for DNA synthesis revealed by structure, modeling and mutagenesis of the accessory subunit of human mitochondrial DNA polymerase. Kaguni LS 2006 Journal of molecular biology
Functional defects due to spacer-region mutations of human mitochondrial DNA polymerase in a family with an ataxia-myopathy syndrome. Kaguni LS 2005 Human molecular genetics
Mutations in the spacer region of Drosophila mitochondrial DNA polymerase affect DNA binding, processivity, and the balance between Pol and Exo function. Kaguni LS 2005 The Journal of biological chemistry
Physiological and biochemical defects in functional interactions of mitochondrial DNA polymerase and DNA-binding mutants of single-stranded DNA-binding protein. Kaguni LS 2004 The Journal of biological chemistry
DNA polymerase gamma, the mitochondrial replicase. Kaguni LS 2004 Annu Rev Biochem
The accessory subunit of DNA polymerase gamma is essential for mitochondrial DNA maintenance and development in Drosophila melanogaster. Kaguni LS 2002 Proceedings of the National Academy of Sciences of the United States of America
Purification strategies for Drosophila mtDNA replication proteins in native and recombinant form. DNA polymerase gamma. Kaguni LS 2002 Methods in molecular biology (Clifton, N.J.)
Multiple regions of subunit interaction in Drosophila mitochondrial DNA polymerase: three functional domains in the accessory subunit. Kaguni LS 2001 Biochemistry
The highly compact structure of the mitochondrial DNA polymerase genomic region of Drosophila melanogaster: functional and evolutionary implications. Kaguni LS 2000 Insect molecular biology
Overexpression of the catalytic subunit of DNA polymerase gamma results in depletion of mitochondrial DNA in Drosophila melanogaster. Kaguni LS 2000 Mol Gen Genet
Differential regulation of the catalytic and accessory subunit genes of Drosophila mitochondrial DNA polymerase. Kaguni LS 2000 The Journal of biological chemistry
Functional interactions of mitochondrial DNA polymerase and single-stranded DNA-binding protein. Template-primer DNA binding and initiation and elongation of DNA strand synthesis. Kaguni LS 1999 The Journal of biological chemistry
Baculovirus expression reconstitutes Drosophila mitochondrial DNA polymerase. Kaguni LS 1999 The Journal of biological chemistry
The accessory subunit of mtDNA polymerase shares structural homology with aminoacyl-tRNA synthetases: implications for a dual role as a primer recognition factor and processivity clamp. Kaguni LS 1999 Proceedings of the National Academy of Sciences of the United States of America
Accessory subunit of mitochondrial DNA polymerase from Drosophila embryos. Cloning, molecular analysis, and association in the native enzyme. Kaguni LS 1997 The Journal of biological chemistry
Catalytic subunit of mitochondrial DNA polymerase from Drosophila embryos. Cloning, bacterial overexpression, and biochemical characterization. Kaguni LS 1996 The Journal of biological chemistry
Subunit structure of mitochondrial DNA polymerase from Drosophila embryos. Physical and immunological studies. Kaguni LS 1995 The Journal of biological chemistry
Stimulation of Drosophila mitochondrial DNA polymerase by single-stranded DNA-binding protein. Kaguni LS 1995 The Journal of biological chemistry
Mitochondrial single-stranded DNA-binding protein from Drosophila embryos. Physical and biochemical characterization. Kaguni LS 1995 The Journal of biological chemistry
Processivity of mitochondrial DNA polymerase from Drosophila embryos. Effects of reaction conditions and enzyme purity. Kaguni LS 1993 The Journal of biological chemistry
3'-->5' exonuclease in Drosophila mitochondrial DNA polymerase. Substrate specificity and functional coordination of nucleotide polymerization and mispair hydrolysis. Kaguni LS 1992 The Journal of biological chemistry
Mismatch-specific 3'----5' exonuclease associated with the mitochondrial DNA polymerase from Drosophila embryos. Kaguni LS 1989 Proceedings of the National Academy of Sciences of the United States of America
DNA polymerase alpha. Kaguni LS 1989 The Journal of biological chemistry
Eukaryotic DNA polymerase-primase: structure, mechanism and function. Kaguni LS 1988 Biochimica et biophysica acta
Mitochondrial DNA polymerase from Drosophila melanogaster embryos: kinetics, processivity, and fidelity of DNA polymerization. Kaguni LS 1988 Biochemistry
A mitochondrial DNA polymerase from embryos of Drosophila melanogaster. Purification, subunit structure, and partial characterization. Kaguni LS 1986 The Journal of biological chemistry
The DNA polymerase-primase from drosophila melanogaster embryos. Rate and fidelity of polymerization on single-stranded DNA templates. Kaguni LS 1984 The Journal of biological chemistry
Association of DNA primase with the beta/gamma subunits of DNA polymerase alpha from Drosophila melanogaster embryos. Kaguni LS 1983 The Journal of biological chemistry
Isolation of an intact DNA polymerase-primase from embryos of Drosophila melanogaster. Kaguni LS 1983 Proceedings of the National Academy of Sciences of the United States of America
Template-directed pausing in in vitro DNA synthesis by DNA polymerase a from Drosophila melanogaster embryos. Kaguni LS 1982 Proceedings of the National Academy of Sciences of the United States of America
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