A novel processive mechanism for DNA synthesis revealed by structure, modeling and mutagenesis of the accessory subunit of human mitochondrial DNA polymerase.

Abstract:

Mitochondrial DNA polymerase (pol gamma) is the sole DNA polymerase ...

Polymerases:

Topics:

Kinetic Parameters, Structure and Structure/Function, Nucleotide Incorporation, Exonuclease Activity

Status:

new topics/pols set partial results complete validated

Results:

Polymerase Reference Property Result Context
Human Pol gamma A novel processive mechanism for DNA synthesis revealed by structure, modeling and mutagenesis of the accessory subunit of human mitochondrial DNA polymerase. 3-5' Exonuclease (proofreading) Yes
Human Pol gamma A novel processive mechanism for DNA synthesis revealed by structure, modeling and mutagenesis of the accessory subunit of human mitochondrial DNA polymerase. Processivity 586bp
Human Pol gamma A novel processive mechanism for DNA synthesis revealed by structure, modeling and mutagenesis of the accessory subunit of human mitochondrial DNA polymerase. Kd 10.2nM Reaction: Polymerase-DNA interaction; Substrate: DNA template