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Sweasy JB

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Publications:

Title Authors Year Journal
Fluorescence resonance energy transfer studies of DNA polymerase β: the critical role of fingers domain movements and a novel non-covalent step during nucleotide selection. Sweasy JB 2014 The Journal of biological chemistry
Structural changes in the hydrophobic hinge region adversely affect the activity and fidelity of the I260Q mutator of DNA polymerase ß Sweasy JB 2013 Biochemistry
Cellular roles of DNA polymerase beta. Sweasy JB 2013 The Yale journal of biology and medicine
The E295K cancer variant of human polymerase beta favors the mismatch conformational pathway during nucleotide selection. Sweasy JB 2013 The Journal of biological chemistry
The human gastric cancer-associated DNA polymerase β variant D160N is a mutator that induces cellular transformation. Sweasy JB 2012 DNA repair
Substrate-Dependent Millisecond Domain Motions in DNA Polymerase β Sweasy JB 2012 Journal of molecular biology
Y265C DNA polymerase beta knockin mice survive past birth and accumulate base excision repair intermediate substrates. Sweasy JB 2012 Proceedings of the National Academy of Sciences of the United States of America
A germline polymorphism of DNA polymerase Beta induces genomic instability and cellular transformation. Sweasy JB 2012 PLoS genetics
Catalytic Effects of Mutations of Distant Protein Residues in Human DNA Polymerase β: Theory and Experiment. Sweasy JB 2012 Biochemistry
DNA Polymerase β Variant Ile260Met Generates Global Gene Expression Changes Related to Cellular Transformation. Sweasy JB 2012 Mutagenesis
Mouse models of DNA polymerases. Sweasy JB 2012 Environmental and molecular mutagenesis
The E288K Colon Tumor Variant of DNA Polymerase Beta Is a Sequence Specific Mutator. Sweasy JB 2012 Biochemistry
Unfavorable electrostatic and steric interactions in DNA polymerase β E295K mutant interfere with the enzyme's pathway. Sweasy JB 2012 Journal of the American Chemical Society
The Human POLB Gene is Mutated in a High Percentage of Colorectal Tumors. Sweasy JB 2012 The Journal of biological chemistry
DNA polymerase beta is critical for genomic stability of sperm cells. Sweasy JB 2011 DNA repair
A triad interaction in the fingers subdomain of DNA polymerase beta controls polymerase activity. Sweasy JB 2011 Journal of the American Chemical Society
A Triad Interaction in the Fingers Subdomain of DNA Polymerase Beta Controls Polymerase Activity Sweasy JB 2011 Journal of the American Chemical Society
Nucleosome Disruption by DNA Ligase III-XRCC1 Promotes Efficient Base Excision Repair. Sweasy JB 2011 Molecular and cellular biology
DNA polymerase family X: function, structure, and cellular roles. Sweasy JB 2010 Biochimica et biophysica acta
DNA polymerase beta is critical for mouse meiotic synapsis. Sweasy JB 2010 The EMBO journal
Hinge residue I174 is critical for proper dNTP selection by DNA polymerase beta. Sweasy JB 2010 Biochemistry
Potentiation of temozolomide cytotoxicity by inhibition of DNA polymerase beta is accentuated by BRCA2 mutation. Sweasy JB 2010 Cancer research
Population-specific variation in haplotype composition and heterozygosity at the POLB locus. Sweasy JB 2009 DNA repair
Loop II of DNA polymerase beta is important for discrimination during substrate binding. Sweasy JB 2009 DNA repair
The I260Q variant of DNA polymerase beta extends mispaired primer termini due to its increased affinity for deoxynucleotide triphosphate substrates. Sweasy JB 2008 Biochemistry
The Leu22Pro tumor-associated variant of DNA polymerase beta is dRP lyase deficient. Sweasy JB 2008 Nucleic acids research
The Asp285 variant of DNA polymerase beta extends mispaired primer termini via increased nucleotide binding. Sweasy JB 2008 Biochemistry
The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation. Sweasy JB 2007 Molecular and cellular biology
Loop II of DNA polymerase beta is important for polymerization activity and fidelity. Sweasy JB 2007 Nucleic acids research
DNA polymerase 4 of Saccharomyces cerevisiae is important for accurate repair of methyl-methanesulfonate-induced DNA damage. Sweasy JB 2006 Genetics
Is base excision repair a tumor suppressor mechanism? Sweasy JB 2006 Cell cycle (Georgetown, Tex.)
DNA polymerases and human diseases. Sweasy JB 2006 Radiat Res
Expression of DNA polymerase {beta} cancer-associated variants in mouse cells results in cellular transformation. Sweasy JB 2005 Proceedings of the National Academy of Sciences of the United States of America
The hydrophobic hinge region of rat DNA polymerase beta is critical for substrate binding pocket geometry. Sweasy JB 2005 The Journal of biological chemistry
Hinge residue Ile260 of DNA polymerase beta is important for enzyme activity and fidelity. Sweasy JB 2005 Biochemistry
Prostate-cancer-associated I260M variant of DNA polymerase beta is a sequence-specific mutator. Sweasy JB 2005 Biochemistry
The D246V mutant of DNA polymerase beta misincorporates nucleotides: evidence for a role for the flexible loop in DNA positioning within the active site. Sweasy JB 2004 The Journal of biological chemistry
A DNA polymerase beta mutant from colon cancer cells induces mutations. Sweasy JB 2004 Proceedings of the National Academy of Sciences of the United States of America
Is there a link between DNA polymerase beta and cancer? Sweasy JB 2004 Cell Cycle
DNA polymerase beta interacts with TRF2 and induces telomere dysfunction in a murine mammary cell line. Sweasy JB 2004 Cancer research
Variants of DNA polymerase Beta extend mispaired DNA due to increased affinity for nucleotide substrate. Sweasy JB 2003 Biochemistry
Fidelity mechanisms of DNA polymerase beta. Sweasy JB 2003 Prog Nucleic Acid Res Mol Biol
Threonine 79 is a hinge residue that governs the fidelity of DNA polymerase beta by helping to position the DNA within the active site. Sweasy JB 2002 The Journal of biological chemistry
Interaction of DNA polymerase beta with GRIP1 during meiosis. Sweasy JB 2001 Chromosoma
Y265H mutator mutant of DNA polymerase beta. Proper teometric alignment is critical for fidelity. Sweasy JB 2001 The Journal of biological chemistry
A DNA polymerase beta mutator mutant with reduced nucleotide discrimination and increased protein stability. Sweasy JB 2001 Biochemistry
The Tyr-265-to-Cys mutator mutant of DNA polymerase beta induces a mutator phenotype in mouse LN12 cells. Sweasy JB 1999 Proceedings of the National Academy of Sciences of the United States of America
The E249K mutator mutant of DNA polymerase beta extends mispaired termini. Sweasy JB 1999 The Journal of biological chemistry
Involvement of phenylalanine 272 of DNA polymerase beta in discriminating between correct and incorrect deoxynucleoside triphosphates. Sweasy JB 1999 Biochemistry
3'-Azido-3'-deoxythymidine-resistant mutants of DNA polymerase beta identified by in vivo selection. Sweasy JB 1999 The Journal of biological chemistry
The mutator form of polymerase beta with amino acid substitution at tyrosine 265 in the hinge region displays an increase in both base substitution and frame shift errors. Sweasy JB 1998 Biochemistry
The Pol beta-14 dominant negative rat DNA polymerase beta mutator mutant commits errors during the gap-filling step of base excision repair in Saccharomyces cerevisiae. Sweasy JB 1998 J Bacteriol
A genetic system to identify DNA polymerase beta mutator mutants. Sweasy JB 1997 Proceedings of the National Academy of Sciences of the United States of America
Evidence for a role for DNA polymerase beta in mammalian meiosis. Sweasy JB 1997 Proceedings of the National Academy of Sciences of the United States of America
Increased activity and fidelity of DNA polymerase beta on single-nucleotide gapped DNA. Sweasy JB 1997 The Journal of biological chemistry
Dominant negative rat DNA polymerase beta mutants interfere with base excision repair in Saccharomyces cerevisiae. Sweasy JB 1996 J Bacteriol
DNA polymerase beta can substitute for DNA polymerase I in the initiation of plasmid DNA replication. Sweasy JB 1995 J Bacteriol
Characterization of DNA polymerase beta mutants with amino acid substitutions located in the C-terminal portion of the enzyme. Sweasy JB 1995 Mol Gen Genet
Evidence against DNA polymerase beta as a candidate gene for Werner syndrome. Sweasy JB 1994 Hum Genet
Detection and characterization of mammalian DNA polymerase beta mutants by functional complementation in Escherichia coli. Sweasy JB 1993 Proceedings of the National Academy of Sciences of the United States of America
Mammalian DNA polymerase beta can substitute for DNA polymerase I during DNA replication in Escherichia coli. Sweasy JB 1992 The Journal of biological chemistry

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