HHV5
From
Human cytomegalovirus
(aliases:HSV-5, HCMV, HSV5, HFLF2, UL54, human cytomegalovirus DNA polymerase)
Welcome to the Polymerase Page
This page presents all the information in Polbase for HHV5.
Mutants:At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.
Structures/Sequence:If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.
External links:Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.
References:All references that refer to this Polymerase are listed with their topics and paper's title in the References table.
Results:All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.
Help icons:
The symbol in the upper-right corner of the page
links to this help text. The question mark icon is used everywhere to indicate that help is available.
HHV5
is a family B enzyme
from
Human cytomegalovirus.
Selected Properties for HHV5: |
3'-5' exo activity | 5'-3' exo activity | Frameshift Rate | Substitution Rate | General Error Rate |
|---|---|---|---|---|---|
| no data | no data | no data | no data | no data |
- References (40)
- Structures (1)
- Sequences (1)
- Mutants (4)...
- Formulations (0)
- Polymerase Lots (0)
- External links
| Year | Authors | Title | Results by property |
|---|---|---|---|
| 2013 | Serena Massari, Beatrice Mercorelli, Luca Sancineto, Stefano Sabatini, Violetta Cecchetti, Giorgio Gribaudo, Giorgio Palù, Christophe Pannecouque, Arianna Loregian, Oriana Tabarrini | Design, Synthesis, and Evaluation of ... | |
| 2013 | Sébastien Hantz, Sébastien Cotin, Eva Borst, Anthony Couvreux, Arielle Salmier, Isabelle Garrigue, Pierre Merville, Catherine Mengelle, Michel Attal, Martin Messerle, Sophie Alain | Novel DNA polymerase mutations confer... | |
| 2012 | Blair L Strang, Steeve Boulant, Tomas Kirchhausen, Donald M Coen | Host cell nucleolin is required to ma... | |
| 2012 | Blair L Strang, Brian J Bender, Mayuri Sharma, Jean M Pesola, Rebecca L Sanders, Deborah H Spector, Donald M Coen | A Mutation Deleting Sequences Encodin... | |
| 2011 | Laurie A Silva, Blair L Strang, Eric W Lin, Jeremy P Kamil, Donald M Coen | Sites and roles of phosphorylation of... | |
| 2011 | Sunwen Chou | Phenotypic diversity of cytomegalovir... | |
| 2011 | Karl E Zahn, Egor P Tchesnokov, Matthias Götte, Sylvie Doublié | Phosphonoformic acid inhibits viral r... | |
| 2011 | Sunwen Chou, Gail Marousek, T L Bowlin | Cyclopropavir Susceptibility of Cytom... | |
| 2010 | Blair L Strang, Steeve Boulant, Donald M Coen | Nucleolin associates with the human c... | |
| 2010 | Laurie A Silva, Arianna Loregian, Gregory S Pari, Blair L Strang, Donald M Coen | The carboxy-terminal segment of the h... | |
| 2009 | Gualtiero Alvisi, Daniela Martino Roth, Daria Camozzi, Gregory S Pari, Arianna Loregian, Alessandro Ripalti, David A Jans | The flexible loop of the human cytome... | |
| 2009 | Blair L Strang, Elisa Sinigalia, Laurie A Silva, Donald M Coen, Arianna Loregian | Analysis of the association of the hu... | |
| 2008 | Gloria Komazin-Meredith, Robert J Petrella, Webster L Santos, David J Filman, James M Hogle, Gregory L Verdine, Martin Karplus, Donald M Coen | The human cytomegalovirus UL44 C clam... | |
| 2008 | Elisa Sinigalia, Gualtiero Alvisi, Beatrice Mercorelli, Donald M Coen, Gregory S Pari, David A Jans, Alessandro Ripalti, Giorgio Palù, Arianna Loregian | Role of homodimerization of human cyt... | |
| 2008 | Ran Tao, Miaofeng Hu, Qunjun Duan, Shiqiang Shang | Efficient inhibition of human cytomeg... | |
| 2007 | Scott D Larsen, Zhijun Zhang, Brian A DiPaolo, Peter R Manninen, Douglas C Rohrer, Michael J Hageman, Todd A Hopkins, Mary L Knechtel, Nancee L Oien, Bob D Rush, Francis J Schwende, Kevin J Stefanski, Janet L Wieber, Karen F Wilkinson, Kathyrn M Zamora, Michael W Wathen, Roger J Brideau | 7-Oxo-4,7-dihydrothieno[3,2-b]pyridin... | |
| 2007 | Frédéric Picard-Jean, Isabelle Bougie, Martin Bisaillon | Characterization of the DNA- and dNTP... | |
| 2007 | Arianna Loregian, Elisa Sinigalia, Beatrice Mercorelli, Giorgio Palù, Donald M Coen | Binding parameters and thermodynamics... | |
| 2006 | Brent A Appleton, Justin Brooks, Arianna Loregian, David J Filman, Donald M Coen, James M Hogle | Crystal structure of the cytomegalovi... | |
| 2006 | Egor P Tchesnokov, Christian Gilbert, Guy Boivin, Matthias Götte | Role of helix P of the human cytomega... | |
| 2006 | Gualtiero Alvisi, Alessandro Ripalti, Apollinaire Ngankeu, Maila Giannandrea, Stefano G Caraffi, Manisha M Dias, David A Jans | Human cytomegalovirus DNA polymerase ... | |
| 2005 | Alexandra Ducancelle, Sophie Alain, C Scieux, A-M Fillet, Françoise Petit, M-J Sanson-Le Pors, M-C Mazeron | [A novel colorimetric test to study t... | |
| 2004 | Arianna Loregian, Brent A Appleton, James M Hogle, Donald M Coen | Residues of human cytomegalovirus DNA... | |
| 2004 | Brent A Appleton, Arianna Loregian, David J Filman, Donald M Coen, James M Hogle | The cytomegalovirus DNA polymerase su... | |
| 2004 | Arianna Loregian, Brent A Appleton, James M Hogle, Donald M Coen | Specific residues in the connector lo... | |
| 2003 | Arianna Loregian, Roberto Rigatti, Mary C Murphy, Elisabetta Schievano, Giorgio Palù, Howard S Marsden | Inhibition of human cytomegalovirus D... | |
| 2000 | V A Vaillancourt, M M Cudahy, S A Staley, Roger J Brideau, S J Conrad, Mary L Knechtel, Nancee L Oien, Janet L Wieber, Y Yagi, Michael W Wathen | Naphthalene carboxamides as inhibitor... | |
| 2000 | M Kariya, S Mori, Y Eizuru | Comparison of human cytomegalovirus D... | |
| 1999 | Sunwen Chou, Nell S Lurain, Adriana Weinberg, G Y Cai, P L Sharma, C S Crumpacker | Interstrain variation in the human cy... | |
| 1997 | Xiwen Xiong, J L Smith, M S Chen | Effect of incorporation of cidofovir ... | |
| 1997 | T Cihlar, M D Fuller, J M Cherrington | Expression of the catalytic subunit (... | |
| 1996 | J A Kerry, M A Priddy, T Y Jervey, C P Kohler, T L Staley, C D Vanson, T R Jones, A C Iskenderian, D G Anders, R M Stenberg | Multiple regulatory events influence ... | |
| 1996 | Xiwen Xiong, J L Smith, C Kim, E S Huang, M S Chen | Kinetic analysis of the interaction o... | |
| 1996 | A Marcello, G Pisoni, S Pizzighella, Giorgio Palù | Measurement of human cytomegalovirus-... | |
| 1993 | V Sullivan, K K Biron, C Talarico, S C Stanat, M Davis, L M Pozzi, Donald M Coen | A point mutation in the human cytomeg... | |
| 1993 | M P Landini, T Lazzarotto, P F Ertl | Humoral immune response to human cyto... | |
| 1992 | P F Ertl, K L Powell | Physical and functional interaction o... | |
| 1991 | P F Ertl, M S Thomas, K L Powell | High level expression of DNA polymera... | |
| 1985 | E Gönczöl, S A Plotkin | Effect of DNA polymerase inhibitors o... | |
| 1979 | K Yamanishi, F Rapp | Induction of host DNA synthesis and D... |
Protein sequence:
| Name | 3'-5' exo activity | 5'-3' exo activity | Frameshift Rate | Substitution Rate | General Error Rate |
|---|---|---|---|---|---|
| HHV5 N408S | |||||
| HHV5 E756D | |||||
| HHV5 M844V | |||||
| HHV5 A987G |
Protein information: Uniprot P08546 search for HHV5 at UniProt
Sequence information: NCBI nucleotides European nucleotide archive