Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms.

Abstract:

Classical "antimutator" DNA polymerases of bacteriophage T4 were ...

Polymerases:

Topics:

Mutational Analysis, Fidelity

One line summary:

Antimutator type T4 mutants were shown to have frameshift mutator activities among certain quasi-palindromic sequences, while reducing frameshift mutations in the A:T-run DNA sequences.

Status:

new topics/pols set partial results complete validated

Results:

Polymerase Reference Property Result Context
T4 A737V Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. Frameshift Error Rate 4.2 Mutation frequency (relative to WT) Technique: T4 rIIB N-terminal frameshift assay ((rFC41; 1b-b2, a - frameshift))
T4 A737V Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. Frameshift Error Rate 1.5 Mutation frequency (relative to WT) Technique: T4 rIIB N-terminal frameshift assay ((rFC40; 1b-b4, a - frameshift))
T4 A737V Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. Frameshift Error Rate 11 Mutation frequency (relative to WT) Technique: T4 rIIB N-terminal frameshift assay ((rFC47; 1b-b7, a - frameshift))
T4 A737V Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. Frameshift Error Rate 0.13 Mutation frequency (relative to WT) Technique: T4 rII 131 reversion
T4 A737V Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. Frameshift Error Rate 0.48 Mutation frequency (relative to WT) Technique: T4 rII UV6 reversion
T4 A737V Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. Frameshift Error Rate 0.65 Mutation frequency (relative to WT) Technique: T4 rII 114 reversion
T4 A737V Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. Frameshift Error Rate 6 Mutation frequency (relative to WT) Technique: T4 rIIB N-terminal frameshift assay ((rFC11; b1-mb, a + frameshift))
T4 A737V Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. Frameshift Error Rate 3.5 Mutation frequency (relative to WT) Technique: T4 rIIB N-terminal frameshift assay ((rFC7; b3-mb, a + frameshift))
T4 A737V Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. Frameshift Error Rate 22 Mutation frequency (relative to WT) Technique: T4 rIIB N-terminal frameshift assay ((rX146; b6-mb, a + frameshift))
T4 A777V Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. Frameshift Error Rate 0.63 Mutation frequency (relative to WT) Technique: T4 rIIB N-terminal frameshift assay ((rFC41; 1b-b2, a - frameshift)
T4 A777V Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. Frameshift Error Rate 3.4 Mutation frequency (relative to WT) Technique: T4 rIIB N-terminal frameshift assay ((rFC47; 1b-b7, a - frameshift))
T4 A777V Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. Frameshift Error Rate 0.2 Mutation frequency (relative to WT) Technique: T4 rII 131 reversion
T4 A777V Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. Frameshift Error Rate 0.18 Mutation frequency (relative to WT) Technique: T4 rII UV6 reversion
T4 A777V Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. Frameshift Error Rate 0.51 Mutation frequency (relative to WT) Technique: T4 rII 114 reversion
T4 A777V Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. Frameshift Error Rate 1.4 Mutation frequency (relative to WT) Technique: T4 rIIB N-terminal frameshift assay ((rFC11; b1-mb, a + frameshift))
T4 A777V Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. Frameshift Error Rate 2.3 Mutation frequency (relative to WT) Technique: T4 rIIB N-terminal frameshift assay ((rFC7; b3-mb, a + frameshift))
T4 A777V Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. Frameshift Error Rate 125 Mutation frequency (relative to WT) Technique: T4 rIIB N-terminal frameshift assay ((rX146; b6-mc, a + frameshift))

Entry validated by: