Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms.
Abstract:
Polymerases:
Topics:
Mutational Analysis, Fidelity
One line summary:
Antimutator type T4 mutants were shown to have frameshift mutator activities among certain quasi-palindromic sequences, while reducing frameshift mutations in the A:T-run DNA sequences.
Status:
new | topics/pols set | partial results | complete | validated |
Results:
Polymerase | Reference | Property | Result | Context |
---|---|---|---|---|
T4 A737V | Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. | Frameshift Error Rate | 4.2 Mutation frequency (relative to WT) | Technique: T4 rIIB N-terminal frameshift assay ((rFC41; 1b-b2, a - frameshift)) |
T4 A737V | Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. | Frameshift Error Rate | 1.5 Mutation frequency (relative to WT) | Technique: T4 rIIB N-terminal frameshift assay ((rFC40; 1b-b4, a - frameshift)) |
T4 A737V | Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. | Frameshift Error Rate | 11 Mutation frequency (relative to WT) | Technique: T4 rIIB N-terminal frameshift assay ((rFC47; 1b-b7, a - frameshift)) |
T4 A737V | Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. | Frameshift Error Rate | 0.13 Mutation frequency (relative to WT) | Technique: T4 rII 131 reversion |
T4 A737V | Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. | Frameshift Error Rate | 0.48 Mutation frequency (relative to WT) | Technique: T4 rII UV6 reversion |
T4 A737V | Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. | Frameshift Error Rate | 0.65 Mutation frequency (relative to WT) | Technique: T4 rII 114 reversion |
T4 A737V | Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. | Frameshift Error Rate | 6 Mutation frequency (relative to WT) | Technique: T4 rIIB N-terminal frameshift assay ((rFC11; b1-mb, a + frameshift)) |
T4 A737V | Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. | Frameshift Error Rate | 3.5 Mutation frequency (relative to WT) | Technique: T4 rIIB N-terminal frameshift assay ((rFC7; b3-mb, a + frameshift)) |
T4 A737V | Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. | Frameshift Error Rate | 22 Mutation frequency (relative to WT) | Technique: T4 rIIB N-terminal frameshift assay ((rX146; b6-mb, a + frameshift)) |
T4 A777V | Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. | Frameshift Error Rate | 0.63 Mutation frequency (relative to WT) | Technique: T4 rIIB N-terminal frameshift assay ((rFC41; 1b-b2, a - frameshift) |
T4 A777V | Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. | Frameshift Error Rate | 3.4 Mutation frequency (relative to WT) | Technique: T4 rIIB N-terminal frameshift assay ((rFC47; 1b-b7, a - frameshift)) |
T4 A777V | Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. | Frameshift Error Rate | 0.2 Mutation frequency (relative to WT) | Technique: T4 rII 131 reversion |
T4 A777V | Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. | Frameshift Error Rate | 0.18 Mutation frequency (relative to WT) | Technique: T4 rII UV6 reversion |
T4 A777V | Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. | Frameshift Error Rate | 0.51 Mutation frequency (relative to WT) | Technique: T4 rII 114 reversion |
T4 A777V | Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. | Frameshift Error Rate | 1.4 Mutation frequency (relative to WT) | Technique: T4 rIIB N-terminal frameshift assay ((rFC11; b1-mb, a + frameshift)) |
T4 A777V | Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. | Frameshift Error Rate | 2.3 Mutation frequency (relative to WT) | Technique: T4 rIIB N-terminal frameshift assay ((rFC7; b3-mb, a + frameshift)) |
T4 A777V | Mutator versus antimutator activity of a T4 DNA polymerase mutant distinguishes two different frameshifting mechanisms. | Frameshift Error Rate | 125 Mutation frequency (relative to WT) | Technique: T4 rIIB N-terminal frameshift assay ((rX146; b6-mc, a + frameshift)) |