The incorporation of O6-methyldeoxyguanosine and O4-methyldeoxythymidine monophosphates into DNA by DNA polymerases I and alpha.

Hall JA, Saffhill R
Nucleic acids research (1983), Volume 11, Page 4185
PubMed entry Full article text

Abstract:

The modified nucleoside 5'-triphosphates O6-MedGTP ad O4-MedTTP have ...
The modified nucleoside 5'-triphosphates O6-MedGTP ad O4-MedTTP have been synthesised and their acceptability as DNA-precursors investigated using DNA polymerases I and alpha in an in vitro assay. O6-MedGMP is only incorporated into newly-synthesized DNA-like material in the presence of templates containing thymine bases. Similarly O4-MedTMP is only incorporated in the presence of templates containing guanine bases. The results confirm the promutagenic nature and base-pairing properties of O6-MeG ad O4-MeT.

Polymerases:

Eco Pol I,Human Pol alpha

Topics:

Nucleotide Incorporation

Status:

new topics/pols set partial results complete validated

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