Human Pol alpha

From H. sapiens (aliases:pol α, DNA polymerase alpha) (genes: POLA1)
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Welcome to the Polymerase Page

This page presents all the information in Polbase for Human Pol alpha.

Mutants:

At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.

Structures/Sequence:

If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.

External links:

Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.

References:

All references that refer to this Polymerase are listed with their topics and paper's title in the References table.

Results:

All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.

Help icons:

The show help symbol in the upper-right corner of the page links to this help text. The question mark icon is used everywhere to indicate that help is available.

Human Pol alpha is a family B enzyme from H. sapiens.

Selected Properties for Human Pol alpha:

3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
No (5) No (3) 4.0e-05-3.1e-04 errors/bp (2) 1.3e-06-2.6e-04 errors/bp (6) 5.0e-05-3.0e-03 errors/bp (2)
Year Authors Title Results by property
P Hafkemeyer, K A Neftel, Ulrich Hübscher Hafkemeyer P
2013 Rajika L Perera, R Torella, Sebastian Klinge, Mairi L Kilkenny, JD Maman, Luca Pellegrini Perera RL2013
2013 Valentina Aria, Mariarita De Felice, Roberta Di Perna, Shuji Uno, Hisao Masai, Juhani E Syvaoja, Barbara van Loon, Ulrich Hubscher, Francesca M Pisani Aria V2013
2012 Markku Vaara, Harri Itkonen, Tomi Hillukkala, Zhe Liu, Heinz Peter Nasheuer, Daniel Schaarschmidt, Helmut Pospiech, Juhani E Syväoja Vaara M2012
2011 Yoshiyuki Mizushina, Naoki Maeda, Isoko Kuriyama, Hiromi Yoshida Mizushina Y2011
2011 Ryuya Fujii, Atsushi Minami, Tae Tsukagoshi, Natsuko Sato, Takehiko Sahara, Satoru Ohgiya, Katsuya Gomi, Hideaki Oikawa Fujii R2011
2011 Barbara Zdrazil, Anja Schwanke, Birte Schmitz, Monika Schäfer-Korting, Hans-Dieter Höltje Zdrazil B2011
2011 Vladimir P Bermudez, A Farina, V Raghavan, Inger Tappin, Jerard Hurwitz Bermudez VP2011
2011 Yoshiyuki Mizushina, Jun Maeda, Yasuhiro Irino, Masayuki Nishida, Shin Nishiumi, Yasuyuki Kondo, Kazuyuki Nishio, Kouji Kuramochi, Kazunori Tsubaki, Isoko Kuriyama, Takeshi Azuma, Hiromi Yoshida, Masaru Yoshida Mizushina Y2011
2011 Kazuki Kobayashi, Shin Nishiumi, Masayuki Nishida, Midori Hirai, Takeshi Azuma, Hiromi Yoshida, Yoshiyuki Mizushina, Masaru Yoshida Kobayashi K2011
2010 Shigeru Tanaka, Ke Cao, Atsuko Niimi, Siripan Limsirichaikul, Huang Qin Miao, Noriko Nakamura, Takashi Murate, Yoshinori Hasegawa, Tomonori Takahashi, Motoshi Suzuki Tanaka S2010
2010 Mark D Sutton Sutton MD2010
2010 Sandeep N Shah, Patricia L Opresko, Xiao Meng, Marietta Y W T Lee, Kristin A Eckert Shah SN2010
2010 Linda J Reha-Krantz Reha-Krantz LJ2010
2010 Christopher Van, Shan Yan, W Matthew Michael, Shou Waga, Karlene A Cimprich Van C2010
2010 Ken Hirano, Yuichiro Yoshida, Tomomi Ishido, Yukihisa Wada, Naoji Moriya, Naoshi Yamazaki, Yoshiyuki Mizushina, Yoshinobu Baba, Mitsuru Ishikawa Hirano K2010
2009 Eric M Warren, Hao Huang, Ellen Fanning, Walter J Chazin, Brandt F Eichman Warren EM2009
2009 Shan Yan, W Matthew Michael Yan S2009
2009 Tahir H Tahirov, Kira S Makarova, Igor B Rogozin, Youri I Pavlov, Eugene V Koonin Tahirov TH2009
2009 Yuki Matsui, Takahiko Hada, Naoki Maeda, Yoshihiro Sato, Yasuhiro Yamaguchi, Toshifumi Takeuchi, Masaharu Takemura, Fumio Sugawara, Kengo Sakaguchi, Hiromi Yoshida, Yoshiyuki Mizushina Matsui Y2009
2009 Jennifer N Patro, Milan Urban, Robert D Kuchta Patro JN2009
2009 Gudrun Stengel, Byron W Purse, L Marcus Wilhelmsson, Milan Urban, Robert D Kuchta Stengel G2009
2009 Jennifer N Patro, Milan Urban, Robert D Kuchta Patro JN2009
2008 Linda J Reha-Krantz Reha-Krantz LJ2008
2008 PD Robertson, Eric M Warren, Haijiang Zhang, DB Friedman, JW Lary, JL Cole, AV Tutter, JC Walter, Ellen Fanning, Brandt F Eichman Robertson PD2008
2008 Anja Richartz, Monika Höltje, Birte Brandt, Monika Schäfer-Korting, Hans-Dieter Höltje Richartz A2008
2007 Jeff W Beckman, Kristi Kincaid, Michal Hocek, Thomas E Spratt, Joachim W Engels, Richard Cosstick, Robert D Kuchta Beckman JW2007
2007 Hirotomo Nakata, Masayuki Amano, Yasuhiro Koh, Eiichi N Kodama, Guangwei Yang, Christopher M Bailey, Satoru Kohgo, Hiroyuki Hayakawa, Masao Matsuoka, Karen S Anderson, Yung-Chi Cheng, Hiroyuki Mitsuya Nakata H2007
2007 Mariarosaria De Falco, Elena Ferrari, Mariarita De Felice, Mosè Rossi, Ulrich Hübscher, Francesca M Pisani De Falco M2007
2006 Anna K Rytkönen, Tomi Hillukkala, Markku Vaara, Miiko Sokka, Maarit Jokela, Raija Sormunen, Heinz Peter Nasheuer, Tamar Nethanel, Gabriel Kaufmann, Helmut Pospiech, Juhani E Syväoja Rytkönen AK2006
2005 Tomonori Takahashi, Zhenghua Min, Iichiro Uchida, Michitsune Arita, Yoh Watanabe, Minoru Koi, Hiromichi Hemmi Takahashi T2005
2005 William T Wolfle, Robert E Johnson, Irina G Minko, R Stephen Lloyd, Satya Prakash, Louise Prakash Wolfle WT2005
2005 Emmanuele Crespan, Samantha Zanoli, Anastasiya Khandazhinskaya, Igor V Shevelev, Maxim Jasko, Ludmila Alexandrova, Marina Kukhanova, Giuseppina Blanca, Giuseppe Villani, Ulrich Hübscher, Silvio Spadari, Giovanni Maga Crespan E2005
2004 Katherine A Richardson, Tanya P Vega, Frank C Richardson, Chad L Moore, John C Rohloff, Blake Tomkinson, Raymond A Bendele, Robert D Kuchta Richardson KA2004
2004 Youri I Pavlov, Satoko Maki, Hisaji Maki, Thomas A Kunkel Pavlov YI2004 3-5' exo,5-3' exo,All properties
2004 Naomi Suzuki, Manabu Yasui, Y R Santosh Laxmi, Haruo Ohmori, Fumio Hanaoka, Shinya Shibutani Suzuki N2004
2003 Molly Chiaramonte, Chad L Moore, Kristi Kincaid, Robert D Kuchta Chiaramonte M2003
2003 Ferenc Evanics, Leila Maurmann, Wei Wen Yang, Rathindra N Bose Evanics F2003
2003 Siripan Limsirichaikul, Masanori Ogawa, Atsuko Niimi, Shigenori Iwai, Takashi Murate, Shonen Yoshida, Motoshi Suzuki Limsirichaikul S2003
2002 Richard W P Smith, Claudia Steffen, Frank Grosse, Heinz Peter Nasheuer Smith RW2002
2002 Robert D Ott, Christoph Rehfuess, Vladimir N Podust, Jill E Clark, Ellen Fanning Ott RD2002
2002 Ulrich Hubscher, Giovanni Maga, Silvio Spadari Hubscher U2002
2001 Phillip A Furman, J Jeffrey, L L Kiefer, Joy Y Feng, Karen S Anderson, K Borroto-Esoda, E Hill, William C Copeland, Chung K Chu, J P Sommadossi, I Liberman, Raymond F Schinazi, George R Painter Furman PA2001
2000 Frank C Richardson, Robert D Kuchta, A Mazurkiewicz, Katherine A Richardson Richardson FC2000
2000 T Niki, I Galli, H Ariga, S M Iguchi-Ariga Niki T2000
2000 Eiji Ohashi, Katarzyna Bebenek, Toshiro Matsuda, William J Feaver, Valerie L Gerlach, Errol C Friedberg, Haruo Ohmori, Thomas A Kunkel Ohashi E2000 Nucleotide Substitution Rate,All properties
1999 C Voitenleitner, Christoph Rehfuess, M Hilmes, L O'Rear, P C Liao, D A Gage, Robert Ott, Heinz Peter Nasheuer, Ellen Fanning Voitenleitner C1999
1999 E Efrati, G Tocco, R Eritja, Samuel H Wilson, Myron F Goodman Efrati E1999
1999 J M de Muys, H Gourdeau, N Nguyen-Ba, D L Taylor, P S Ahmed, T Mansour, C Locas, N Richard, Mark A. Wainberg, R F Rando de Muys JM1999
1999 K L Conger, Jen-Sing Liu, Shu-Ru Kuo, L T Chow, Teresa S-F Wang Conger KL1999
1999 Thomas A Steitz Steitz TA1999
1998 A Schneider, Richard W P Smith, A R Kautz, Klaus Weisshart, Frank Grosse, Heinz Peter Nasheuer Schneider A1998
1998 A Tomikawa, M Seno, K Sato-Kiyotaki, C Ohtsuki, T Hirai, Tsuyoshi Yamaguchi, T Kawaguchi, Shonen Yoshida, Mineo Saneyoshi Tomikawa A1998
1998 S G Huang, Klaus Weisshart, I Gilbert, Ellen Fanning Huang SG1998
1997 Ashwini S Kamath-Loeb, A Hizi, Hironori Kasai, Lawrence A Loeb Kamath-Loeb AS1997
1997 V Gandhi, P Huang, A J Chapman, F Chen, W Plunkett Gandhi V1997
1997 E Efrati, G Tocco, R Eritja, Samuel H Wilson, Myron F Goodman Efrati E1997
1996 T I Kolocheva, G A Maksakova, O D Zakharova, G A Nevinsky Kolocheva TI1996
1996 F B Perler, Sandeep Kumar, H Kong Perler FB1996 Full length or truncated,3-5' exo,5-3' exo,All properties
1996 J Y Mo, Roel M Schaaper Mo JY1996 Cloned or native,Full length or truncated,Specific Activity,Gap fill,3-5' exo,Frameshift Error Rate,Nucleotide Substitution Rate,Overall Error Rate,All properties
1995 Hiroyuki Kamiya, Hironori Kasai Kamiya H1995 KM,Vmax,All properties
1995 Federico Focher, Giovanni Maga, A Bendiscioli, M Capobianco, F Colonna, A Garbesi, Silvio Spadari Focher F1995
1995 Hiroyuki Kamiya, Tadamasa Ueda, T Ohgi, Akio Matsukage, Hironori Kasai Kamiya H1995
1995 T H Broschard, M Wiessler, H H Schmeiser Broschard TH1995
1995 T Melendy, Juhan Sedman, A Stenlund Melendy T1995
1995 R R Vyas, A K Basu Vyas RR1995
1995 D G Semizarov, M V Ias'ko, M K Kukhanova, A A Kraevskiĭ Semizarov DG1995
1995 Q Dong, Teresa S-F Wang Dong Q1995
1994 P Hentosh, P Grippo Hentosh P1994
1994 S Niranjanakumari, K P Gopinathan Niranjanakumari S1994
1994 Shonen Yoshida, C M Simbulan Yoshida S1994
1993 William C Copeland, Teresa S-F Wang Copeland WC1993
1993 Svetlana N Khodyreva, Vladimir N Podust, D S Sergeev, E M Ivanova, E I Frolova, A A Koshkin, T S Godovikova, V F Zarytova, Miria Ricchetti, Olga I Lavrik Khodyreva SN1993
1993 Q Dong, William C Copeland, Teresa S-F Wang Dong Q1993
1993 K L Collins, A A Russo, B Y Tseng, T J Kelly Collins KL1993
1993 I Dornreiter, William C Copeland, Teresa S-F Wang Dornreiter I1993
1993 William C Copeland, N K Lam, Teresa S-F Wang Copeland WC1993
1993 Kristin A Eckert, Thomas A Kunkel Eckert KA1993 Cloned or native,Full length or truncated,Specific Activity,Nucleotide Substitution Rate,All properties
1993 Q Dong, William C Copeland, Teresa S-F Wang Dong Q1993
1993 G Bialek, Frank Grosse Bialek G1993
1993 Vladimir N Podust, Ulrich Hübscher Podust VN1993
1993 M S Chen, R T Suttmann, E Papp, P D Cannon, M J McRoberts, C Bach, William C Copeland, Teresa S-F Wang Chen MS1993
1992 Dmitry A Gordenin, A L Malkova, A Peterzen, V N Kulikov, Youri I Pavlov, E Perkins, Michael A Resnick Gordenin DA1992
1992 Silvio Spadari, Federico Focher, Ulrich Hübscher Spadari S1992
1992 Unknown1992
1992 H Hao, Yanan Jiang, S J Zhang, Peiming Zhang, R X Zeng, Marietta Y W T Lee Hao H1992
1992 William C Copeland, M S Chen, Teresa S-F Wang Copeland WC1992 Cloned or native,Tagged,Full length or truncated,KM,Kd,Vmax,Application name,Incorporation of non-standard nucleotides,All properties
1992 Fred W Perrino, H L Mekosh Perrino FW1992
1992 S V Doronin, M I Dobrikov, Olga I Lavrik Doronin SV1992
1992 J A Burrows, C R Goward Burrows JA1992
1991 T Weiser, M Gassmann, P Thömmes, Elena Ferrari, P Hafkemeyer, Ulrich Hübscher Weiser T1991 Specific Activity,Processivity,3-5' exo,5-3' exo,RNase H,All properties
1991 Heinz Peter Nasheuer, A Moore, A F Wahl, Teresa S-F Wang Nasheuer HP1991
1991 N N Khan, George E Wright, Neal C Brown Khan NN1991
1991 P A Leegwater, M Strating, N B Murphy, R F Kooy, Peter C van der Vliet, J P Overdulve Leegwater PA1991
1991 P Hafkemeyer, K Neftel, R Hobi, A Pfaltz, H Lutz, K Lüthi, Federico Focher, Silvio Spadari, Ulrich Hübscher Hafkemeyer P1991
1991 Alessandra Montecucco, M Fontana, Federico Focher, M Lestingi, Silvio Spadari, G Ciarrocchi Montecucco A1991
1991 K B Frank, G J Noll, E V Connell, I S Sim Frank KB1991
1991 William C Copeland, Teresa S-F Wang Copeland WC1991
1990 G A Nevinskiĭ, I A Potapova, N B Tarusova, O V Khalabuda, V V Khomov Nevinskiĭ GA1990
1990 K L Hsi, William C Copeland, Teresa S-F Wang Hsi KL1990
1990 Y Tsutsumi, S Hori, N Onoda Tsutsumi Y1990
1990 Peter M J Burgers, Robert A Bambara, Judith L Campbell, L M Chang, Kathleen M Downey, Ulrich Hübscher, Marietta Y W T Lee, Stuart Linn, Antero G So, Silvio Spadari Burgers PM1990
1990 I A Potapova, G A Nevinsky, A G Veniaminova, V V Khomov, Olga I Lavrik Potapova IA1990
1990 Vladimir N Podust, T O Korobeinicheva, G A Nevinsky, A S Levina, Olga I Lavrik Podust VN1990
1990 T Matsumoto, Toshihiko Eki, Jerard Hurwitz Matsumoto T1990
1989 J E Reardon Reardon JE1989
1989 Olga I Lavrik, G A Nevinskiĭ, I A Potapova, N B Tarusova, O V Khalabuda Lavrik OI1989
1989 A Morrison, R B Christensen, J Alley, A K Beck, E G Bernstine, J F Lemontt, Christopher W Lawrence Morrison A1989
1989 L Ng, S J Weiss, Paul A Fisher Ng L1989
1989 Vladimir N Podust, Olga I Lavrik, Heinz Peter Nasheuer, Frank Grosse Podust VN1989
1989 Federico Focher, M Gassmann, P Hafkemeyer, Elena Ferrari, Silvio Spadari, Ulrich Hübscher Focher F1989
1988 S W Wong, A F Wahl, P M Yuan, N Arai, B E Pearson, K Arai, D Korn, M W Hunkapiller, Teresa S-F Wang Wong SW1988 3-5' exo,All properties
1988 H Nakane, Jan Balzarini, Erik De Clercq, K Ono Nakane H1988
1988 J D Roberts, Thomas A Kunkel Roberts JD1988
1987 R Namikawa, T Suchi, R Ueda, G Itoh, K Koike, K Ota, T Takahashi Namikawa R1987
1987 M S Boosalis, John Petruska, Myron F Goodman Boosalis MS1987 KM,Vmax,All properties
1987 Olga I Lavrik, A S Levina, G A Nevinsky, Vladimir N Podust Lavrik OI1987
1987 R W Donaldson, E W Gerner Donaldson RW1987
1987 R Namikawa, R Ueda, T Suchi, G Itoh, K Ota, T Takahashi Namikawa R1987
1987 G A Nevinskiĭ, S V Doronin, Vladimir N Podust, Olga I Lavrik Nevinskiĭ GA1987
1986 Hiroshi Miyazawa, M Tandai, Fumio Hanaoka, Masami Yamada, T Hori, Kikuo Shimizu, M Sekiguchi Miyazawa H1986
1986 L Kaczmarek, M R Miller, R A Hammond, W E Mercer Kaczmarek L1986
1986 Marietta Y W T Lee, N L Toomey Lee MY1986
1986 M Tsuda, M Masuyama, T Katsunuma Tsuda M1986
1985 C W Greider, E H Blackburn Greider CW1985
1985 M R Miller, R G Ulrich, Teresa S-F Wang, D Korn Miller MR1985
1984 Fumio Hanaoka, M Tandai, Hiroshi Miyazawa, Y Murakami, T Hori, Masami Yamada Hanaoka F1984
1983 J A Hall, R Saffhill Hall JA1983
1982 Ulrich Hübscher, P Gerschwiler, G K McMaster Hübscher U1982
1982 Shigeru Tanaka, S Z Hu, Teresa S-F Wang, D Korn Tanaka S1982
1982 K G Bensch, Shigeru Tanaka, S Z Hu, Teresa S-F Wang, D Korn Bensch KG1982
1981 M Geuskens, N Hardt, G Pedrali-Noy, Silvio Spadari Geuskens M1981
1981 Paul A Fisher, D Korn Fisher PA1981
1981 F Sala, M G Galli, M Levi, D Burroni, B Parisi, G Pedrali-Noy, Silvio Spadari Sala F1981
1980 G Pedrali-Noy, Silvio Spadari, A Miller-Faurès, A O Miller, J Kruppa, G Koch Pedrali-Noy G1980
1980 G Pedrali-Noy, Silvio Spadari Pedrali-Noy G1980
1980 George E Wright, E F Baril, Neal C Brown Wright GE1980
1980 F Sala, B Parisi, D Burroni, A R Amileni, G Pedrali-Noy, Silvio Spadari Sala F1980
1979 P F Pignatti, E Cassai, U Bertazzoni Pignatti PF1979
1979 Paul A Fisher, Teresa S-F Wang, D Korn Fisher PA1979 Full length or truncated,Processivity,Nick Extension,Gap fill,KM,All properties
1979 G Pedrali-Noy, Silvio Spadari Pedrali-Noy G1979
1979 Y Ono, Takemi Enomoto, Masami Yamada Ono Y1979
1979 Ulrich Hübscher, C C Kuenzle, W Limacher, P Scherrer, Silvio Spadari Hübscher U1979
1978 P Bhattacharya, S Basu Bhattacharya P1978
1978 Mochihiko Ohashi, Takahiko Taguchi, S Ikegami Ohashi M1978
1978 R Dicioccio, B I Srivastava Dicioccio R1978
1978 B Novak, E F Baril Novak B1978
1978 T Shimada, Masami Yamada, M Miwa, H Nagano, Y Mano Shimada T1978
1978 M A Waqar, M J Evans, J A Huberman Waqar MA1978
1977 D C Eichler, Paul A Fisher, D Korn Eichler DC1977
1977 Paul A Fisher, D Korn Fisher PA1977
1977 Ulrich Hübscher, C C Kuenzle, Silvio Spadari Hübscher U1977
1976 U Bertazzoni, M Stefanini, G P Noy, E Giulotto, F Nuzzo, A Falaschi, Silvio Spadari Bertazzoni U1976
1976 G Herrick, B B Spear, G Veomett Herrick G1976
1975 Silvio Spadari, A Weissbach Spadari S1975
1975 R G Smith, J W Abrell, B J Lewis, R C Gallo Smith RG1975
1975 G M Brun, L M Assairi, F Chapeville Brun GM1975
1975 R W Chiu, E F Baril Chiu RW1975
1975 R J Mayer, R G Smith, R C Gallo Mayer RJ1975
1974 Silvio Spadari, R Muller, A Weissbach Spadari S1974
1974 Silvio Spadari, A Weissbach Spadari S1974
1973 E F Baril, M D Jenkins, O E Brown, J Laszlo, H P Morris Baril EF1973
1973 N B Hecht Hecht NB1973
1973 L H Lazarus, N Kitron Lazarus LH1973
1973 R A Bucknall, H Moores, R Simms, B Hesp Bucknall RA1973
1973 L M Chang, M Brown, F J Bollum Chang LM1973
1972 L M Chang, F J Bollum Chang LM1972
1972 B Fridlender, M Fry, A Bolden, A Weissbach Fridlender B1972
1965 M YONEDA, F J Bollum YONEDA M1965 Optimal pH,All properties
1956 M FRIEDKIN, D TILSON, D ROBERTS FRIEDKIN M1956
1956 M FRIEDKIN, H I V WOOD FRIEDKIN M1956
Protein sequence:
DNA sequence:
Name 3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
pol alpha L864F
pol alpha G952A
All Polymerases | 70 Results

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