Human Pol alpha
From
H. sapiens
(aliases:pol α, DNA polymerase alpha)
(genes: POLA1)
Welcome to the Polymerase Page
This page presents all the information in Polbase for Human Pol alpha.
Mutants:At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.
Structures/Sequence:If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.
External links:Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.
References:All references that refer to this Polymerase are listed with their topics and paper's title in the References table.
Results:All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.
Help icons:
The symbol in the upper-right corner of the page
links to this help text. The question mark icon is used everywhere to indicate that help is available.
Human Pol alpha
is a family B enzyme
from
H. sapiens.
Selected Properties for Human Pol alpha: |
3'-5' exo activity | 5'-3' exo activity | Frameshift Rate | Substitution Rate | General Error Rate |
|---|---|---|---|---|---|
| No (5) | No (3) | 4.0e-05-3.1e-04 errors/bp (2) | 1.3e-06-2.6e-04 errors/bp (6) | 5.0e-05-3.0e-03 errors/bp (2) |
- References (171)
- Structures (4)
- Sequences (1)
- Mutants (2)...
- Formulations (0)
- Polymerase Lots (0)
- External links
| Year | Authors | Title | Results by property |
|---|---|---|---|
| P Hafkemeyer, K A Neftel, Ulrich Hübscher | HIV-reverse transcriptase and human D... | ||
| 2013 | Rajika L Perera, R Torella, Sebastian Klinge, Mairi L Kilkenny, JD Maman, Luca Pellegrini | Mechanism for priming DNA synthesis b... | |
| 2013 | Valentina Aria, Mariarita De Felice, Roberta Di Perna, Shuji Uno, Hisao Masai, Juhani E Syvaoja, Barbara van Loon, Ulrich Hubscher, Francesca M Pisani | The Human Tim/Tipin Complex Directly ... | |
| 2012 | Markku Vaara, Harri Itkonen, Tomi Hillukkala, Zhe Liu, Heinz Peter Nasheuer, Daniel Schaarschmidt, Helmut Pospiech, Juhani E Syväoja | Segregation of replicative DNA polyme... | |
| 2011 | Yoshiyuki Mizushina, Naoki Maeda, Isoko Kuriyama, Hiromi Yoshida | Dehydroaltenusin is a specific inhibi... | |
| 2011 | Ryuya Fujii, Atsushi Minami, Tae Tsukagoshi, Natsuko Sato, Takehiko Sahara, Satoru Ohgiya, Katsuya Gomi, Hideaki Oikawa | Total biosynthesis of diterpene aphid... | |
| 2011 | Barbara Zdrazil, Anja Schwanke, Birte Schmitz, Monika Schäfer-Korting, Hans-Dieter Höltje | Molecular modelling studies of new po... | |
| 2011 | Vladimir P Bermudez, A Farina, V Raghavan, Inger Tappin, Jerard Hurwitz | Studies on Human DNA Polymerase {epsi... | |
| 2011 | Yoshiyuki Mizushina, Jun Maeda, Yasuhiro Irino, Masayuki Nishida, Shin Nishiumi, Yasuyuki Kondo, Kazuyuki Nishio, Kouji Kuramochi, Kazunori Tsubaki, Isoko Kuriyama, Takeshi Azuma, Hiromi Yoshida, Masaru Yoshida | Effects of Intermediates between Vita... | |
| 2011 | Kazuki Kobayashi, Shin Nishiumi, Masayuki Nishida, Midori Hirai, Takeshi Azuma, Hiromi Yoshida, Yoshiyuki Mizushina, Masaru Yoshida | Effects of quinone derivatives, such ... | |
| 2010 | Shigeru Tanaka, Ke Cao, Atsuko Niimi, Siripan Limsirichaikul, Huang Qin Miao, Noriko Nakamura, Takashi Murate, Yoshinori Hasegawa, Tomonori Takahashi, Motoshi Suzuki | Functions of base selection step in h... | |
| 2010 | Mark D Sutton | Coordinating DNA polymerase traffic d... | |
| 2010 | Sandeep N Shah, Patricia L Opresko, Xiao Meng, Marietta Y W T Lee, Kristin A Eckert | DNA structure and the Werner protein ... | |
| 2010 | Linda J Reha-Krantz | DNA polymerase proofreading: Multiple... | |
| 2010 | Christopher Van, Shan Yan, W Matthew Michael, Shou Waga, Karlene A Cimprich | Continued primer synthesis at stalled... | |
| 2010 | Ken Hirano, Yuichiro Yoshida, Tomomi Ishido, Yukihisa Wada, Naoji Moriya, Naoshi Yamazaki, Yoshiyuki Mizushina, Yoshinobu Baba, Mitsuru Ishikawa | Consecutive incorporation of fluoroph... | |
| 2009 | Eric M Warren, Hao Huang, Ellen Fanning, Walter J Chazin, Brandt F Eichman | Physical interactions between Mcm10, ... | |
| 2009 | Shan Yan, W Matthew Michael | TopBP1 and DNA polymerase-alpha direc... | |
| 2009 | Tahir H Tahirov, Kira S Makarova, Igor B Rogozin, Youri I Pavlov, Eugene V Koonin | Evolution of DNA polymerases: an inac... | |
| 2009 | Yuki Matsui, Takahiko Hada, Naoki Maeda, Yoshihiro Sato, Yasuhiro Yamaguchi, Toshifumi Takeuchi, Masaharu Takemura, Fumio Sugawara, Kengo Sakaguchi, Hiromi Yoshida, Yoshiyuki Mizushina | Structure and activity relationship o... | |
| 2009 | Jennifer N Patro, Milan Urban, Robert D Kuchta | Role of the 2-amino group of purines ... | |
| 2009 | Gudrun Stengel, Byron W Purse, L Marcus Wilhelmsson, Milan Urban, Robert D Kuchta | Ambivalent incorporation of the fluor... | |
| 2009 | Jennifer N Patro, Milan Urban, Robert D Kuchta | Interaction of human DNA polymerase a... | |
| 2008 | Linda J Reha-Krantz | Recent patents of gene sequences rela... | |
| 2008 | PD Robertson, Eric M Warren, Haijiang Zhang, DB Friedman, JW Lary, JL Cole, AV Tutter, JC Walter, Ellen Fanning, Brandt F Eichman | Domain architecture and biochemical c... | |
| 2008 | Anja Richartz, Monika Höltje, Birte Brandt, Monika Schäfer-Korting, Hans-Dieter Höltje | Targeting human DNA polymerase alpha ... | |
| 2007 | Jeff W Beckman, Kristi Kincaid, Michal Hocek, Thomas E Spratt, Joachim W Engels, Richard Cosstick, Robert D Kuchta | Human DNA polymerase alpha uses a com... | |
| 2007 | Hirotomo Nakata, Masayuki Amano, Yasuhiro Koh, Eiichi N Kodama, Guangwei Yang, Christopher M Bailey, Satoru Kohgo, Hiroyuki Hayakawa, Masao Matsuoka, Karen S Anderson, Yung-Chi Cheng, Hiroyuki Mitsuya | Activity against human immunodeficien... | |
| 2007 | Mariarosaria De Falco, Elena Ferrari, Mariarita De Felice, Mosè Rossi, Ulrich Hübscher, Francesca M Pisani | The human GINS complex binds to and s... | |
| 2006 | Anna K Rytkönen, Tomi Hillukkala, Markku Vaara, Miiko Sokka, Maarit Jokela, Raija Sormunen, Heinz Peter Nasheuer, Tamar Nethanel, Gabriel Kaufmann, Helmut Pospiech, Juhani E Syväoja | DNA polymerase epsilon associates wit... | |
| 2005 | Tomonori Takahashi, Zhenghua Min, Iichiro Uchida, Michitsune Arita, Yoh Watanabe, Minoru Koi, Hiromichi Hemmi | Hypersensitivity in DNA mismatch repa... | |
| 2005 | William T Wolfle, Robert E Johnson, Irina G Minko, R Stephen Lloyd, Satya Prakash, Louise Prakash | Human DNA polymerase iota promotes re... | |
| 2005 | Emmanuele Crespan, Samantha Zanoli, Anastasiya Khandazhinskaya, Igor V Shevelev, Maxim Jasko, Ludmila Alexandrova, Marina Kukhanova, Giuseppina Blanca, Giuseppe Villani, Ulrich Hübscher, Silvio Spadari, Giovanni Maga | Incorporation of non-nucleoside triph... | |
| 2004 | Katherine A Richardson, Tanya P Vega, Frank C Richardson, Chad L Moore, John C Rohloff, Blake Tomkinson, Raymond A Bendele, Robert D Kuchta | Polymerization of the triphosphates o... | |
| 2004 | Youri I Pavlov, Satoko Maki, Hisaji Maki, Thomas A Kunkel | Evidence for interplay among yeast re... | 3-5' exo,5-3' exo,All properties |
| 2004 | Naomi Suzuki, Manabu Yasui, Y R Santosh Laxmi, Haruo Ohmori, Fumio Hanaoka, Shinya Shibutani | Translesion synthesis past equine est... | |
| 2003 | Molly Chiaramonte, Chad L Moore, Kristi Kincaid, Robert D Kuchta | Facile polymerization of dNTPs bearin... | |
| 2003 | Ferenc Evanics, Leila Maurmann, Wei Wen Yang, Rathindra N Bose | Nuclear magnetic resonance structures... | |
| 2003 | Siripan Limsirichaikul, Masanori Ogawa, Atsuko Niimi, Shigenori Iwai, Takashi Murate, Shonen Yoshida, Motoshi Suzuki | The Gly-952 residue of Saccharomyces ... | |
| 2002 | Richard W P Smith, Claudia Steffen, Frank Grosse, Heinz Peter Nasheuer | Species specificity of simian virus 4... | |
| 2002 | Robert D Ott, Christoph Rehfuess, Vladimir N Podust, Jill E Clark, Ellen Fanning | Role of the p68 subunit of human DNA ... | |
| 2002 | Ulrich Hubscher, Giovanni Maga, Silvio Spadari | Eukaryotic DNA polymerases. | |
| 2001 | Phillip A Furman, J Jeffrey, L L Kiefer, Joy Y Feng, Karen S Anderson, K Borroto-Esoda, E Hill, William C Copeland, Chung K Chu, J P Sommadossi, I Liberman, Raymond F Schinazi, George R Painter | Mechanism of action of 1-beta-D-2,6-d... | |
| 2000 | Frank C Richardson, Robert D Kuchta, A Mazurkiewicz, Katherine A Richardson | Polymerization of 2'-fluoro- and 2'-O... | |
| 2000 | T Niki, I Galli, H Ariga, S M Iguchi-Ariga | MSSP, a protein binding to an origin ... | |
| 2000 | Eiji Ohashi, Katarzyna Bebenek, Toshiro Matsuda, William J Feaver, Valerie L Gerlach, Errol C Friedberg, Haruo Ohmori, Thomas A Kunkel | Fidelity and processivity of DNA synt... | Nucleotide Substitution Rate,All properties |
| 1999 | C Voitenleitner, Christoph Rehfuess, M Hilmes, L O'Rear, P C Liao, D A Gage, Robert Ott, Heinz Peter Nasheuer, Ellen Fanning | Cell cycle-dependent regulation of hu... | |
| 1999 | E Efrati, G Tocco, R Eritja, Samuel H Wilson, Myron F Goodman | "Action-at-a-distance" mutagenesis. 8... | |
| 1999 | J M de Muys, H Gourdeau, N Nguyen-Ba, D L Taylor, P S Ahmed, T Mansour, C Locas, N Richard, Mark A. Wainberg, R F Rando | Anti-human immunodeficiency virus typ... | |
| 1999 | K L Conger, Jen-Sing Liu, Shu-Ru Kuo, L T Chow, Teresa S-F Wang | Human papillomavirus DNA replication.... | |
| 1999 | Thomas A Steitz | DNA polymerases: structural diversity... | |
| 1998 | A Schneider, Richard W P Smith, A R Kautz, Klaus Weisshart, Frank Grosse, Heinz Peter Nasheuer | Primase activity of human DNA polymer... | |
| 1998 | A Tomikawa, M Seno, K Sato-Kiyotaki, C Ohtsuki, T Hirai, Tsuyoshi Yamaguchi, T Kawaguchi, Shonen Yoshida, Mineo Saneyoshi | Synthetic nucleosides and nucleotides... | |
| 1998 | S G Huang, Klaus Weisshart, I Gilbert, Ellen Fanning | Stoichiometry and mechanism of assemb... | |
| 1997 | Ashwini S Kamath-Loeb, A Hizi, Hironori Kasai, Lawrence A Loeb | Incorporation of the guanosine tripho... | |
| 1997 | V Gandhi, P Huang, A J Chapman, F Chen, W Plunkett | Incorporation of fludarabine and 1-be... | |
| 1997 | E Efrati, G Tocco, R Eritja, Samuel H Wilson, Myron F Goodman | Abasic translesion synthesis by DNA p... | |
| 1996 | T I Kolocheva, G A Maksakova, O D Zakharova, G A Nevinsky | The algorithm of estimation of the Km... | |
| 1996 | F B Perler, Sandeep Kumar, H Kong | Thermostable DNA polymerases. | Full length or truncated,3-5' exo,5-3' exo,All properties |
| 1996 | J Y Mo, Roel M Schaaper | Fidelity and error specificity of the... | Cloned or native,Full length or truncated,Specific Activity,Gap fill,3-5' exo,Frameshift Error Rate,Nucleotide Substitution Rate,Overall Error Rate,All properties |
| 1995 | Hiroyuki Kamiya, Hironori Kasai | Formation of 2-hydroxydeoxyadenosine ... | KM,Vmax,All properties |
| 1995 | Federico Focher, Giovanni Maga, A Bendiscioli, M Capobianco, F Colonna, A Garbesi, Silvio Spadari | Stereospecificity of human DNA polyme... | |
| 1995 | Hiroyuki Kamiya, Tadamasa Ueda, T Ohgi, Akio Matsukage, Hironori Kasai | Misincorporation of dAMP opposite 2-h... | |
| 1995 | T H Broschard, M Wiessler, H H Schmeiser | Effect of site-specifically located a... | |
| 1995 | T Melendy, Juhan Sedman, A Stenlund | Cellular factors required for papillo... | |
| 1995 | R R Vyas, A K Basu | DNA polymerase action on an oligonucl... | |
| 1995 | D G Semizarov, M V Ias'ko, M K Kukhanova, A A Kraevskiĭ | [New nucleotide inhibitors of human D... | |
| 1995 | Q Dong, Teresa S-F Wang | Mutational studies of human DNA polym... | |
| 1994 | P Hentosh, P Grippo | Template 2-chloro-2'-deoxyadenosine m... | |
| 1994 | S Niranjanakumari, K P Gopinathan | DNA polymerase alpha-primase complex ... | |
| 1994 | Shonen Yoshida, C M Simbulan | Interaction of poly(ADP-ribose)polyme... | |
| 1993 | William C Copeland, Teresa S-F Wang | Mutational analysis of the human DNA ... | |
| 1993 | Svetlana N Khodyreva, Vladimir N Podust, D S Sergeev, E M Ivanova, E I Frolova, A A Koshkin, T S Godovikova, V F Zarytova, Miria Ricchetti, Olga I Lavrik | Comparison of interactions of 5'-deri... | |
| 1993 | Q Dong, William C Copeland, Teresa S-F Wang | Mutational studies of human DNA polym... | |
| 1993 | K L Collins, A A Russo, B Y Tseng, T J Kelly | The role of the 70 kDa subunit of hum... | |
| 1993 | I Dornreiter, William C Copeland, Teresa S-F Wang | Initiation of simian virus 40 DNA rep... | |
| 1993 | William C Copeland, N K Lam, Teresa S-F Wang | Fidelity studies of the human DNA pol... | |
| 1993 | Kristin A Eckert, Thomas A Kunkel | Fidelity of DNA synthesis catalyzed b... | Cloned or native,Full length or truncated,Specific Activity,Nucleotide Substitution Rate,All properties |
| 1993 | Q Dong, William C Copeland, Teresa S-F Wang | Mutational studies of human DNA polym... | |
| 1993 | G Bialek, Frank Grosse | An error-correcting proofreading exon... | |
| 1993 | Vladimir N Podust, Ulrich Hübscher | Lagging strand DNA synthesis by calf ... | |
| 1993 | M S Chen, R T Suttmann, E Papp, P D Cannon, M J McRoberts, C Bach, William C Copeland, Teresa S-F Wang | Selective action of 4'-azidothymidine... | |
| 1992 | Dmitry A Gordenin, A L Malkova, A Peterzen, V N Kulikov, Youri I Pavlov, E Perkins, Michael A Resnick | Transposon Tn5 excision in yeast: inf... | |
| 1992 | Silvio Spadari, Federico Focher, Ulrich Hübscher | Developmental activity profile of DNA... | |
| 1992 | DNA Replication | ||
| 1992 | H Hao, Yanan Jiang, S J Zhang, Peiming Zhang, R X Zeng, Marietta Y W T Lee | Structural and functional relationshi... | |
| 1992 | William C Copeland, M S Chen, Teresa S-F Wang | Human DNA polymerases alpha and beta ... | Cloned or native,Tagged,Full length or truncated,KM,Kd,Vmax,Application name,Incorporation of non-standard nucleotides,All properties |
| 1992 | Fred W Perrino, H L Mekosh | Incorporation of cytosine arabinoside... | |
| 1992 | S V Doronin, M I Dobrikov, Olga I Lavrik | Photoaffinity labeling of DNA polymer... | |
| 1992 | J A Burrows, C R Goward | Purification and properties of DNA po... | |
| 1991 | T Weiser, M Gassmann, P Thömmes, Elena Ferrari, P Hafkemeyer, Ulrich Hübscher | Biochemical and functional comparison... | Specific Activity,Processivity,3-5' exo,5-3' exo,RNase H,All properties |
| 1991 | Heinz Peter Nasheuer, A Moore, A F Wahl, Teresa S-F Wang | Cell cycle-dependent phosphorylation ... | |
| 1991 | N N Khan, George E Wright, Neal C Brown | The molecular mechanism of inhibition... | |
| 1991 | P A Leegwater, M Strating, N B Murphy, R F Kooy, Peter C van der Vliet, J P Overdulve | The Trypanosoma brucei DNA polymerase... | |
| 1991 | P Hafkemeyer, K Neftel, R Hobi, A Pfaltz, H Lutz, K Lüthi, Federico Focher, Silvio Spadari, Ulrich Hübscher | HP 0.35, a cephalosporin degradation ... | |
| 1991 | Alessandra Montecucco, M Fontana, Federico Focher, M Lestingi, Silvio Spadari, G Ciarrocchi | Specific inhibition of human DNA liga... | |
| 1991 | K B Frank, G J Noll, E V Connell, I S Sim | Kinetic interaction of human immunode... | |
| 1991 | William C Copeland, Teresa S-F Wang | Catalytic subunit of human DNA polyme... | |
| 1990 | G A Nevinskiĭ, I A Potapova, N B Tarusova, O V Khalabuda, V V Khomov | [Interaction of dNTP-binding sites of... | |
| 1990 | K L Hsi, William C Copeland, Teresa S-F Wang | Human DNA polymerase alpha catalytic ... | |
| 1990 | Y Tsutsumi, S Hori, N Onoda | DNA polymerase alpha. An immunohistoc... | |
| 1990 | Peter M J Burgers, Robert A Bambara, Judith L Campbell, L M Chang, Kathleen M Downey, Ulrich Hübscher, Marietta Y W T Lee, Stuart Linn, Antero G So, Silvio Spadari | Revised nomenclature for eukaryotic D... | |
| 1990 | I A Potapova, G A Nevinsky, A G Veniaminova, V V Khomov, Olga I Lavrik | Interaction of dNTP, pyrophosphate an... | |
| 1990 | Vladimir N Podust, T O Korobeinicheva, G A Nevinsky, A S Levina, Olga I Lavrik | Inactivation of DNA polymerase by ade... | |
| 1990 | T Matsumoto, Toshihiko Eki, Jerard Hurwitz | Studies on the initiation and elongat... | |
| 1989 | J E Reardon | Herpes simplex virus type 1 and human... | |
| 1989 | Olga I Lavrik, G A Nevinskiĭ, I A Potapova, N B Tarusova, O V Khalabuda | [Modification of human DNA polymerase... | |
| 1989 | A Morrison, R B Christensen, J Alley, A K Beck, E G Bernstine, J F Lemontt, Christopher W Lawrence | REV3, a Saccharomyces cerevisiae gene... | |
| 1989 | L Ng, S J Weiss, Paul A Fisher | Recognition and binding of template-p... | |
| 1989 | Vladimir N Podust, Olga I Lavrik, Heinz Peter Nasheuer, Frank Grosse | DNA polymerase alpha-DNA primase from... | |
| 1989 | Federico Focher, M Gassmann, P Hafkemeyer, Elena Ferrari, Silvio Spadari, Ulrich Hübscher | Calf thymus DNA polymerase delta inde... | |
| 1988 | S W Wong, A F Wahl, P M Yuan, N Arai, B E Pearson, K Arai, D Korn, M W Hunkapiller, Teresa S-F Wang | Human DNA polymerase alpha gene expre... | 3-5' exo,All properties |
| 1988 | H Nakane, Jan Balzarini, Erik De Clercq, K Ono | Differential inhibition of various de... | |
| 1988 | J D Roberts, Thomas A Kunkel | Fidelity of a human cell DNA replicat... | |
| 1987 | R Namikawa, T Suchi, R Ueda, G Itoh, K Koike, K Ota, T Takahashi | Phenotyping of proliferating lymphocy... | |
| 1987 | M S Boosalis, John Petruska, Myron F Goodman | DNA polymerase insertion fidelity. Ge... | KM,Vmax,All properties |
| 1987 | Olga I Lavrik, A S Levina, G A Nevinsky, Vladimir N Podust | Role of nucleoside components and int... | |
| 1987 | R W Donaldson, E W Gerner | Phosphorylation of a high molecular w... | |
| 1987 | R Namikawa, R Ueda, T Suchi, G Itoh, K Ota, T Takahashi | Double immunoenzymatic detection of s... | |
| 1987 | G A Nevinskiĭ, S V Doronin, Vladimir N Podust, Olga I Lavrik | [Effectiveness of complex-formation o... | |
| 1986 | Hiroshi Miyazawa, M Tandai, Fumio Hanaoka, Masami Yamada, T Hori, Kikuo Shimizu, M Sekiguchi | Identification of a DNA segment conta... | |
| 1986 | L Kaczmarek, M R Miller, R A Hammond, W E Mercer | A microinjected monoclonal antibody a... | |
| 1986 | Marietta Y W T Lee, N L Toomey | Differential effects of dimethylsulfo... | |
| 1986 | M Tsuda, M Masuyama, T Katsunuma | Inhibition of human DNA polymerase al... | |
| 1985 | C W Greider, E H Blackburn | Identification of a specific telomere... | |
| 1985 | M R Miller, R G Ulrich, Teresa S-F Wang, D Korn | Monoclonal antibodies against human D... | |
| 1984 | Fumio Hanaoka, M Tandai, Hiroshi Miyazawa, Y Murakami, T Hori, Masami Yamada | Human DNA polymerase alpha. Compensat... | |
| 1983 | J A Hall, R Saffhill | The incorporation of O6-methyldeoxygu... | |
| 1982 | Ulrich Hübscher, P Gerschwiler, G K McMaster | A mammalian DNA polymerase alpha holo... | |
| 1982 | Shigeru Tanaka, S Z Hu, Teresa S-F Wang, D Korn | Preparation and preliminary character... | |
| 1982 | K G Bensch, Shigeru Tanaka, S Z Hu, Teresa S-F Wang, D Korn | Intracellular localization of human D... | |
| 1981 | M Geuskens, N Hardt, G Pedrali-Noy, Silvio Spadari | An autoradiographic demonstration of ... | |
| 1981 | Paul A Fisher, D Korn | Ordered sequential mechanism of subst... | |
| 1981 | F Sala, M G Galli, M Levi, D Burroni, B Parisi, G Pedrali-Noy, Silvio Spadari | Functional roles of the plant alpha-l... | |
| 1980 | G Pedrali-Noy, Silvio Spadari, A Miller-Faurès, A O Miller, J Kruppa, G Koch | Synchronization of HeLa cell cultures... | |
| 1980 | G Pedrali-Noy, Silvio Spadari | Mechanism of inhibition of herpes sim... | |
| 1980 | George E Wright, E F Baril, Neal C Brown | Butylanilinouracil: a selective inhib... | |
| 1980 | F Sala, B Parisi, D Burroni, A R Amileni, G Pedrali-Noy, Silvio Spadari | Specific and reversible inhibition by... | |
| 1979 | P F Pignatti, E Cassai, U Bertazzoni | Herpes simplex virus DNA synthesis in... | |
| 1979 | Paul A Fisher, Teresa S-F Wang, D Korn | Enzymological characterization of DNA... | Full length or truncated,Processivity,Nick Extension,Gap fill,KM,All properties |
| 1979 | G Pedrali-Noy, Silvio Spadari | Effect of aphidicolin on viral and hu... | |
| 1979 | Y Ono, Takemi Enomoto, Masami Yamada | Variation of two forms of DNA polymer... | |
| 1979 | Ulrich Hübscher, C C Kuenzle, W Limacher, P Scherrer, Silvio Spadari | Functions of DNA polymerases alpha, b... | |
| 1978 | P Bhattacharya, S Basu | DNA polymerase activities in differen... | |
| 1978 | Mochihiko Ohashi, Takahiko Taguchi, S Ikegami | Aphidicolin: a specific inhibitor of ... | |
| 1978 | R Dicioccio, B I Srivastava | Inhibition of deoxyribonucleic acid p... | |
| 1978 | B Novak, E F Baril | HeLa DNA polymerase alpha activity in... | |
| 1978 | T Shimada, Masami Yamada, M Miwa, H Nagano, Y Mano | Differential susceptibilities of DNA ... | |
| 1978 | M A Waqar, M J Evans, J A Huberman | Effect of 2',3'-dideoxythymidine-5'-t... | |
| 1977 | D C Eichler, Paul A Fisher, D Korn | Effect of calcium on the recovery and... | |
| 1977 | Paul A Fisher, D Korn | DNA polymerase-alpha. Purification an... | |
| 1977 | Ulrich Hübscher, C C Kuenzle, Silvio Spadari | Variation of DNA polymerases-alpha, -... | |
| 1976 | U Bertazzoni, M Stefanini, G P Noy, E Giulotto, F Nuzzo, A Falaschi, Silvio Spadari | Variations of DNA polymerase-alpha an... | |
| 1976 | G Herrick, B B Spear, G Veomett | Intracellular localization of mouse D... | |
| 1975 | Silvio Spadari, A Weissbach | RNA-primed DNA synthesis: specific ca... | |
| 1975 | R G Smith, J W Abrell, B J Lewis, R C Gallo | Serological analysis of human deoxyri... | |
| 1975 | G M Brun, L M Assairi, F Chapeville | Immunological relationships between c... | |
| 1975 | R W Chiu, E F Baril | Nuclear DNA polymerases and the HeLa ... | |
| 1975 | R J Mayer, R G Smith, R C Gallo | DNA-metabolizing enzymes in normal hu... | |
| 1974 | Silvio Spadari, R Muller, A Weissbach | The dissimilitude of the low and high... | |
| 1974 | Silvio Spadari, A Weissbach | The interrelation between DNA synthes... | |
| 1973 | E F Baril, M D Jenkins, O E Brown, J Laszlo, H P Morris | DNA polymerases I and II in regenerat... | |
| 1973 | N B Hecht | Interconvertibility of mouse DNA poly... | |
| 1973 | L H Lazarus, N Kitron | Letter: Cytoplasmic DNA polymerase: p... | |
| 1973 | R A Bucknall, H Moores, R Simms, B Hesp | Antiviral effects of aphidicolin, a n... | |
| 1973 | L M Chang, M Brown, F J Bollum | Induction of DNA polymerase in mouse ... | |
| 1972 | L M Chang, F J Bollum | Antigenic relationships in mammalian ... | |
| 1972 | B Fridlender, M Fry, A Bolden, A Weissbach | A new synthetic RNA-dependent DNA pol... | |
| 1965 | M YONEDA, F J Bollum | DEOXYNUCLEOTIDE-POLYMERIZING ENZYMES ... | Optimal pH,All properties |
| 1956 | M FRIEDKIN, D TILSON, D ROBERTS | Studies of deoxyribonucleic acid bios... | |
| 1956 | M FRIEDKIN, H I V WOOD | Utilization of thymidine-C14 by bone ... |
Protein sequence:
Predicted Structure Model
Predicted model
AlphaFold DB
Not experimentally determined
This AlphaFold DB model is predicted and not an experimentally determined structure. View AlphaFold DB entry Download predicted model (.pdb)
Confidence legend (pLDDT)
AlphaFold DB colors residues by predicted confidence. Use high-confidence regions for structural context and treat low-confidence regions cautiously.
- Very high (pLDDT > 90) Backbone and side chains are usually reliable.
- Confident (pLDDT 70-90) Overall fold is usually reliable, but some local detail may shift.
- Low (pLDDT 50-70) Use with caution; this region may be flexible or uncertain.
- Very low (pLDDT < 50) Often disordered or not confidently placed.
| Name | 3'-5' exo activity | 5'-3' exo activity | Frameshift Rate | Substitution Rate | General Error Rate |
|---|---|---|---|---|---|
| pol alpha L864F | |||||
| pol alpha G952A |
Protein information: Uniprot P09884 search for Human Pol alpha at UniProt
Sequence information: NCBI nucleotides European nucleotide archive
Predicted structure: AlphaFold DB entry AF-P09884-F1