On the role of deoxyribonucleic acid polymerase in determining mutation rates. Characterization of the defect in the T4 deoxyribonucleic acid polymerase caused by the ts L88 mutation.

Polymerases:

T4

Topics:

Fidelity, Nucleotide Incorporation, Exonuclease Activity, Source / Purification

One line summary:

The tsL88 (G694S) DNA polymerase had reduced accuracy of nucleotide incorporation.

Status:

new topics/pols set partial results complete validated

Results:

Polymerase Reference Property Result Context
T4 Hershfield MS1973 3-5' Exonuclease (proofreading) Yes
T4 Hershfield MS1973 Cloned or native Native organism
T4 Hershfield MS1973 Tagged No
T4 Hershfield MS1973 Full length or truncated Full length

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