Quinazolin-2-ylamino-quinazolin-4-ols as novel non-nucleoside inhibitors of bacterial DNA polymerase III.

Guiles JW, Sun X, Critchley IA, Ochsner U, Tregay M, Stone K, Bertino J, Green LS, Sabin R, Dean F, Dallmann HG, McHenry CS, Janjic N
Bioorganic & medicinal chemistry letters (2009), Volume 19, Page 800
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Abstract:

High throughput screening led to the discovery of a novel series of ...
High throughput screening led to the discovery of a novel series of quinazolin-2-ylamino-quinazolin-4-ols as a new class of DNA polymerase III inhibitors. The inhibition of chromosomal DNA replication results in bacterial cell death. The synthesis, structure-activity relationships and functional activity are described.

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