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McHenry CS

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Publications:

Title Authors Year Journal
The Rate of Polymerase Release upon Filling the Gap between Okazaki Fragments Is Inadequate to Support Cycling during Lagging Strand Synthesis. McHenry CS 2011 Journal of molecular biology
Polymerase Chaperoning and Multiple ATPase Sites Enable the E. coli DNA Polymerase III Holoenzyme to Rapidly Form Initiation Complexes. McHenry CS 2011 Journal of molecular biology
Breaking the rules: bacteria that use several DNA polymerase IIIs. McHenry CS 2011 EMBO reports
Parallel multiplicative target screening against divergent bacterial replicases: identification of specific inhibitors with broad spectrum potential. McHenry CS 2010 Biochemistry
Only one ATP-binding DnaX subunit is required for initiation complex formation by the Escherichia coli DNA polymerase III holoenzyme. McHenry CS 2010 The Journal of biological chemistry
Reconstitution of the B. subtilis replisome with 13 proteins including two distinct replicases. McHenry CS 2010 Molecular cell
Quinazolin-2-ylamino-quinazolin-4-ols as novel non-nucleoside inhibitors of bacterial DNA polymerase III. McHenry CS 2009 Bioorganic & medicinal chemistry letters
Strand displacement by DNA polymerase III occurs through a tau-psi-chi link to single-stranded DNA-binding protein coating the lagging strand template. McHenry CS 2009 The Journal of biological chemistry
A coproofreading Zn(2+)-dependent exonuclease within a bacterial replicase. McHenry CS 2006 Nature structural & molecular biology
Discovery and characterization of the cryptic psi subunit of the pseudomonad DNA replicase. McHenry CS 2005 The Journal of biological chemistry
A bipartite polymerase-processivity factor interaction: only the internal beta binding site of the alpha subunit is required for processive replication by the DNA polymerase III holoenzyme. McHenry CS 2005 Journal of molecular biology
Reconstitution of a minimal DNA replicase from Pseudomonas aeruginosa and stimulation by non-cognate auxiliary factors. McHenry CS 2005 The Journal of biological chemistry
Chromosomal replicases as asymmetric dimers: studies of subunit arrangement and functional consequences. McHenry CS 2003 Molecular microbiology
DNA polymerase III holoenzyme from Thermus thermophilus identification, expression, purification of components, and use to reconstitute a processive replicase. McHenry CS 2002 The Journal of biological chemistry
A three-domain structure for the delta subunit of the DNA polymerase III holoenzyme delta domain III binds delta' and assembles into the DnaX complex. McHenry CS 2002 The Journal of biological chemistry
tau binds and organizes Escherichia coli replication through distinct domains. Partial proteolysis of terminally tagged tau to determine candidate domains and to assign domain V as the alpha binding domain. McHenry CS 2001 The Journal of biological chemistry
Carboxyl-terminal domain III of the delta' subunit of the DNA polymerase III holoenzyme binds delta. McHenry CS 2001 The Journal of biological chemistry
tau binds and organizes Escherichia coli replication proteins through distinct domains: domain III, shared by gamma and tau, oligomerizes DnaX. McHenry CS 2001 The Journal of biological chemistry
tau binds and organizes Escherichia coli replication proteins through distinct domains. Domain IV, located within the unique C terminus of tau, binds the replication fork, helicase, DnaB. McHenry CS 2001 The Journal of biological chemistry
Tau binds and organizes Escherichia coli replication proteins through distinct domains. Domain III, shared by gamma and tau, binds delta delta ' and chi psi. McHenry CS 2001 The Journal of biological chemistry
Inhibition of purified recombinant reverse transcriptase from wild-type and zidovudine-resistant clinical isolates of human immunodeficiency virus type 1 by zidovudine, stavudine, and lamivudine triphosphates. McHenry CS 2001 The Journal of infectious diseases
Assembly of DNA polymerase III holoenzyme: co-assembly of gamma and tau is inhibited by DnaX complex accessory proteins but stimulated by DNA polymerase III core. McHenry CS 2001 The Journal of biological chemistry
The delta and delta ' subunits of the DNA polymerase III holoenzyme are essential for initiation complex formation and processive elongation. McHenry CS 2001 The Journal of biological chemistry
Carboxyl-terminal domain III of the delta' subunit of DNA polymerase III holoenzyme binds DnaX and supports cooperative DnaX complex assembly. McHenry CS 2001 The Journal of biological chemistry
The DNA polymerase III holoenzyme: an asymmetric dimeric replicative complex with leading and lagging strand polymerases. McHenry CS 2001 Cell
The DnaX-binding subunits delta' and psi are bound to gamma and not tau in the DNA polymerase III holoenzyme. McHenry CS 2000 The Journal of biological chemistry
A novel assembly mechanism for the DNA polymerase III holoenzyme DnaX complex: association of deltadelta' with DnaX(4) forms DnaX(3)deltadelta'. McHenry CS 2000 The EMBO journal
Characterization of the unique C terminus of the Escherichia coli tau DnaX protein. Monomeric C-tau binds alpha AND DnaB and can partially replace tau in reconstituted replication forks. McHenry CS 2000 The Journal of biological chemistry
Mismatch extension by Escherichia coli DNA polymerase III holoenzyme. McHenry CS 1999 The Journal of biological chemistry
Identification of the acidic residues in the active site of DNA polymerase III. McHenry CS 1999 Journal of molecular biology
Role of the core DNA polymerase III subunits at the replication fork. Alpha is the only subunit required for processive replication. McHenry CS 1998 The Journal of biological chemistry
The base substitution and frameshift fidelity of Escherichia coli DNA polymerase III holoenzyme in vitro. McHenry CS 1998 The Journal of biological chemistry
The chi psi subunits of DNA polymerase III holoenzyme bind to single-stranded DNA-binding protein (SSB) and facilitate replication of an SSB-coated template. McHenry CS 1998 The Journal of biological chemistry
Localization of the active site of the alpha subunit of the Escherichia coli DNA polymerase III holoenzyme. McHenry CS 1997 J Bacteriol
Posttranscriptional modification of retroviral primers is required for late stages of DNA replication. McHenry CS 1997 Proceedings of the National Academy of Sciences of the United States of America
A DNA polymerase III holoenzyme-like subassembly from an extreme thermophilic eubacterium. McHenry CS 1997 Journal of molecular biology
tau couples the leading- and lagging-strand polymerases at the Escherichia coli DNA replication fork. McHenry CS 1996 The Journal of biological chemistry
Biotin tagging deletion analysis of domain limits involved in protein-macromolecular interactions. Mapping the tau binding domain of the DNA polymerase III alpha subunit. McHenry CS 1996 The Journal of biological chemistry
Coupling of a replicative polymerase and helicase: a tau-DnaB interaction mediates rapid replication fork movement. McHenry CS 1996 Cell
In vivo assembly of overproduced DNA polymerase III. Overproduction, purification, and characterization of the alpha, alpha-epsilon, and alpha-epsilon-theta subunits. McHenry CS 1996 The Journal of biological chemistry
Tau protects beta in the leading-strand polymerase complex at the replication fork. McHenry CS 1996 The Journal of biological chemistry
Identification of the beta-binding domain of the alpha subunit of Escherichia coli polymerase III holoenzyme. McHenry CS 1996 The Journal of biological chemistry
Fluorometric assay for DNA polymerases and reverse transcriptase. McHenry CS 1996 BioTechniques
In vivo assembly of the tau-complex of the DNA polymerase III holoenzyme expressed from a five-gene artificial operon. Cleavage of the tau-complex to form a mixed gamma-tau-complex by the OmpT protease. McHenry CS 1996 The Journal of biological chemistry
Purification of Escherichia coli DNA polymerase III holoenzyme. McHenry CS 1995 Methods in enzymology
Escherichia coli DNA polymerase III holoenzyme subunits alpha, beta, and gamma directly contact the primer-template. McHenry CS 1995 The Journal of biological chemistry
DnaX complex of Escherichia coli DNA polymerase III holoenzyme. Central role of tau in initiation complex assembly and in determining the functional asymmetry of holoenzyme. McHenry CS 1995 The Journal of biological chemistry
DnaX complex of Escherichia coli DNA polymerase III holoenzyme. The chi psi complex functions by increasing the affinity of tau and gamma for delta.delta' to a physiologically relevant range. McHenry CS 1995 The Journal of biological chemistry
DnaX complex of Escherichia coli DNA polymerase III holoenzyme. Physical characterization of the DnaX subunits and complexes. McHenry CS 1995 The Journal of biological chemistry
Escherichia coli DNA polymerase III holoenzyme footprints three helical turns of its primer. McHenry CS 1994 The Journal of biological chemistry
Identification, isolation, and characterization of the structural gene encoding the delta' subunit of Escherichia coli DNA polymerase III holoenzyme. McHenry CS 1993 Journal of bacteriology
Isolation, sequencing and overexpression of the gene encoding the theta subunit of DNA polymerase III holoenzyme. McHenry CS 1993 Nucleic acids research
Identification, isolation, and overexpression of the gene encoding the psi subunit of DNA polymerase III holoenzyme. McHenry CS 1993 J Bacteriol
Identification, molecular cloning and characterization of the gene encoding the chi subunit of DNA polymerase III holoenzyme of Escherichia coli. McHenry CS 1993 Mol Gen Genet
Human immunodeficiency virus reverse transcriptase. Expression in Escherichia coli, purification, and characterization of a functionally and structurally asymmetric dimeric polymerase. McHenry CS 1993 The Journal of biological chemistry
Fluorescence energy transfer between the primer and the beta subunit of the DNA polymerase III holoenzyme. McHenry CS 1992 The Journal of biological chemistry
Coordinated leading- and lagging-strand synthesis at the Escherichia coli DNA replication fork. IV. Reconstitution of an asymmetric, dimeric DNA polymerase III holoenzyme. McHenry CS 1992 The Journal of biological chemistry
Molecular cloning, sequencing, and overexpression of the structural gene encoding the delta subunit of Escherichia coli DNA polymerase III holoenzyme. McHenry CS 1992 J Bacteriol
Coordinated leading- and lagging-strand synthesis at the Escherichia coli DNA replication fork. V. Primase action regulates the cycle of Okazaki fragment synthesis. McHenry CS 1992 The Journal of biological chemistry
Transcriptional organization of the Escherichia coli dnaX gene. McHenry CS 1991 Journal of molecular biology
Escherichia coli DNA polymerase II is stimulated by DNA polymerase III holoenzyme auxiliary subunits. McHenry CS 1991 The Journal of biological chemistry
Proofreading activity of DNA polymerase III responds like elongation activity to auxiliary subunits. McHenry CS 1991 The Journal of biological chemistry
DNA polymerase III holoenzyme. Components, structure, and mechanism of a true replicative complex. McHenry CS 1991 The Journal of biological chemistry
Reduction of the potent DNA polymerase III holoenzyme 3'----5' exonuclease activity by template-primer analogues. McHenry CS 1990 Biochemistry
Dissociation of the DNA polymerase III holoenzyme beta 2 subunits is accompanied by conformational change at distal cysteines 333. McHenry CS 1990 The Journal of biological chemistry
The gamma subunit of DNA polymerase III holoenzyme of Escherichia coli is produced by ribosomal frameshifting. McHenry CS 1990 Proceedings of the National Academy of Sciences of the United States of America
Glutamate overcomes the salt inhibition of DNA polymerase III holoenzyme. McHenry CS 1989 The Journal of biological chemistry
DNA polymerase III holoenzyme of Escherichia coli. McHenry CS 1988 Annual review of biochemistry
The asymmetric dimeric polymerase hypothesis: a progress report. McHenry CS 1988 Biochimica et biophysica acta
Detection of an epitope, not required for polymerization, that is conserved between E.coli DNA polymerases I and III and bacteriophage T4 DNA polymerase. McHenry CS 1988 Nucleic acids research
The dimer of the beta subunit of Escherichia coli DNA polymerase III holoenzyme is dissociated into monomers upon binding magnesium(II). McHenry CS 1988 Biochemistry
Properties of initiation complexes formed between Escherichia coli DNA polymerase III holoenzyme and primed DNA in the absence of ATP. McHenry CS 1987 The Journal of biological chemistry
Characterization of 2'(3')-trinitrophenyl-ATP as an inhibitor of ATP-dependent initiation complex formation between the DNA polymerase III holoenzyme and primed DNA. McHenry CS 1987 The Journal of biological chemistry
Sequence analysis of the Escherichia coli dnaE gene. McHenry CS 1987 Journal of bacteriology
Monoclonal antibodies specific for the tau subunit of the DNA polymerase III holoenzyme of Escherichia coli. Use to demonstrate that tau is the product of the dnaZX gene and that both it and gamma, the dnaZ gene product, are integral components of the same enzyme assembly. McHenry CS 1987 The Journal of biological chemistry
The beta subunit of the Escherichia coli DNA polymerase III holoenzyme interacts functionally with the catalytic core in the absence of other subunits. McHenry CS 1986 The Journal of biological chemistry
Chemical characterization and purification of the beta subunit of the DNA polymerase III holoenzyme from an overproducing strain. McHenry CS 1986 The Journal of biological chemistry
DNA polymerase III holoenzyme of Escherichia coli: components and function of a true replicative complex. McHenry CS 1985 Molecular and cellular biochemistry
Determination of the precise location and orientation of the Escherichia coli dnaE gene. McHenry CS 1984 Journal of bacteriology
Monoclonal antibodies specific for the alpha subunit of the Escherichia coli DNA polymerase III holoenzyme. McHenry CS 1984 The Journal of biological chemistry
DNA polymerase III holoenzyme of Escherichia coli: an asymmetric dimeric replicative complex containing distinguishable leading and lagging strand polymerases. McHenry CS 1984 Adv Exp Med Biol
Adenosine 5'-O-(3-thiotriphosphate) can support the formation of an initiation complex between the DNA polymerase III holoenzyme and primed DNA. McHenry CS 1984 The Journal of biological chemistry
Site-specific pausing of deoxyribonucleic acid synthesis catalyzed by four forms of Escherichia coli DNA polymerase III. McHenry CS 1983 Biochemistry
Excess beta subunit can bypass the ATP requirement for highly processive synthesis by the Escherichia coli DNA polymerase III holoenzyme. McHenry CS 1983 The Journal of biological chemistry
The beta subunit of the DNA polymerase III holoenzyme becomes inaccessible to antibody after formation of an initiation complex with primed DNA. McHenry CS 1982 The Journal of biological chemistry
Cloning and identification of the product of the dnaE gene of Escherichia coli. McHenry CS 1982 Journal of bacteriology
Purification and characterization of DNA polymerase III'. Identification of tau as a subunit of the DNA polymerase III holoenzyme. McHenry CS 1982 The Journal of biological chemistry
Size classes of products synthesized processively by two subassemblies of Escherichia coli DNA polymerase III holoenzyme. McHenry CS 1982 The Journal of biological chemistry
Size classes of products synthesized processively by DNA polymerase III and DNA polymerase III holoenzyme of Escherichia coli. McHenry CS 1981 The Journal of biological chemistry
Purification and characterization of the beta subunit of the DNA polymerase III holoenzyme of Escherichia coli. McHenry CS 1980 The Journal of biological chemistry
DNA polymerase III of Escherichia coli. Purification and identification of subunits. McHenry CS 1979 The Journal of biological chemistry
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