Studies on the biochemical basis of spontaneous mutation. I. A comparison of the deoxyribonucleic acid polymerases of mutator, antimutator, and wild type strains of bacteriophage T4.

Muzyczka N, Poland RL, Bessman MJ
The Journal of biological chemistry (1972), Volume 247, Page 7116
PubMed entry

Polymerases:

T4 A777V,T4,T4 A737V,T4 A89TD363N,T4 F868S,T4 S345P

Topics:

Mutational Analysis, Fidelity, Nucleotide Incorporation, Exonuclease Activity

One line summary:

Spontaneous mutation rate is related to the relative rates of insertion and removal of nucleotides during DNA synthesis; mutations in T4 DNA polymerase which perturb the exonuclease to polymerase ratio result in mutator or antimutator polymerases.

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Version:20241218

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