Studies on the biochemical basis of spontaneous mutation. I. A comparison of the deoxyribonucleic acid polymerases of mutator, antimutator, and wild type strains of bacteriophage T4.



Mutational Analysis, Fidelity, Nucleotide Incorporation, Exonuclease Activity

One line summary:

Spontaneous mutation rate is related to the relative rates of insertion and removal of nucleotides during DNA synthesis; mutations in T4 DNA polymerase which perturb the exonuclease to polymerase ratio result in mutator or antimutator polymerases.


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