Error induction and correction by mutant and wild type T4 DNA polymerases. Kinetic error discrimination mechanisms.

Abstract:

The fidelity of DNA synthesis as determined by the misincorporation of ...

Polymerases:

Topics:

Kinetic Parameters, Fidelity, Exonuclease Activity

One line summary:

Exonuclease correction is undertaken by the free energy difference between mismatched pairs

Status:

new topics/pols set partial results complete validated

Results:

Polymerase Reference Property Result Context
T4 Error induction and correction by mutant and wild type T4 DNA polymerases. Kinetic error discrimination mechanisms. KM 4.6uM Reaction: Nucleotide incorporation; Substrate: dATP; Technique: Primer extension assay
T4 Error induction and correction by mutant and wild type T4 DNA polymerases. Kinetic error discrimination mechanisms. KM 25.9uM Reaction: Nucleotide incorporation; Substrate: n/a; Technique: Primer extension assay (2AP)

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