Translesion synthesis by human DNA polymerase eta across oxidative products of guanine.

Kino K, Ito N, Sugasawa K, Sugiyama H, Hanaoka F
Nucleic Acids Symp Ser (Oxf) (2004), Volume , Page 171
PubMed entry Publisher's site

Abstract:

Guanine is the most oxidizable base among natural bases. 8-Oxoguanine ...
Guanine is the most oxidizable base among natural bases. 8-Oxoguanine (8-oxoG) is the typical oxidative product, but the amount of 8-oxoG does not directly reflect the strength of oxidative stress. Imidazolone, oxazolone and guanidinohydantoin are oxidative products of guanine and 8-oxoG. Here, we investigated enzymatic reactions with human DNA polymerase eta on these lesions.

Polymerases:

Human Pol eta

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