Human Pol eta

From H. sapiens (aliases:Polymerase eta) (genes: POLH)
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Welcome to the Polymerase Page

This page presents all the information in Polbase for Human Pol eta.

Mutants:

At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.

Structures/Sequence:

If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.

External links:

Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.

References:

All references that refer to this Polymerase are listed with their topics and paper's title in the References table.

Results:

All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.

Help icons:

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Human Pol eta is a family Y enzyme from H. sapiens.

Bypasses many template lesions

Selected Properties for Human Pol eta:

3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
no consensus no data 2.4e-03 errors/bp (1) 3.2e-02-3.6e-02 errors/bp (4) 3.0e-02 errors/bp (1)
Year Authors Title Results by property
2013 Masayuki Yamada, Kenji Watanabe, Martin Mistrik, Eva Vesela, Iva Protivankova, Niels Mailand, Myunghee Lee, Hisao Masai, Jiri Lukas, Jiri Bartek Yamada M2013
2013 Yaofeng Zhao, Mark T Gregory, Christian Biertümpfel, Yue-Jin Hua, Fumio Hanaoka, Wei Wen Yang Zhao Y2013
2013 Michael Durando, Satoshi Tateishi, Cyrus Vaziri Durando M2013
2013 Leena Maddukuri, Sarah C Shuck, Robert Lawton Eoff, Linlin Zhao, Carmelo J Rizzo, F Peter Guengerich, Lawrence J Marnett Maddukuri L2013 Template lesions,All properties
2013 DJ Taggart, Terry L Camerlengo, Jason K Harrison, Shanen M Sherrer, Ajay K Kshetry, John-Stephen Taylor, Kun Huang, Zucai Suo Taggart DJ2013
2013 Junpei Yamamoto, Tomoko Oyama, Tomohiro Kunishi, Chikahide Masutani, Fumio Hanaoka, Shigenori Iwai Yamamoto J2013
2013 Dechen Fu, Fred Duafalia Dudimah, Jun Zhang, Anna Pickering, Jayabal Paneerselvam, Manikandan Palrasu, Hong Wang, Peiwen Fei Fu D2013
2012 Shanen M Sherrer, DJ Taggart, Lindsey R Pack, Chanchal K Malik, Ashis K Basu, Zucai Suo Sherrer SM2012
2012 S Sharma, Nicholas A Shah, Ariell M Joiner, Katelyn H Roberts, CE Canman Sharma S2012
2012 Ashley L Swanson, Jianshuang Wang, Yinsheng Wang Swanson AL2012
2012 Nils H Nicolay, Rebecca Carter, Stephanie B Hatch, Niklas Schultz, Remko Prevo, W Gillies McKenna, Thomas Helleday, Ricky A Sharma Nicolay NH2012
2012 Yong-Sam Jung, Yingjuan Qian, Xinbin Chen Jung YS2012
2012 Alden C Klarer, L Jay Stallons, Tom J Burke, Robert L Skaggs, W Glenn McGregor Klarer AC2012
2011 Thomas Göhler, Simone Sabbioneda, Catherine M Green, Alan R Lehmann Göhler T2011
2011 Kai-Ming Chou Chou KM2011
2011 Christian Biertümpfel, Yaofeng Zhao, Yuji Kondo, Santiago Ramón-Maiques, Mark T Gregory, Jae Young Lee, Chikahide Masutani, Alan R Lehmann, Fumio Hanaoka, Wei Wen Yang Biertümpfel C2011
2011 Ajay Ummat, Timothy D Silverstein, Rinku Jain, Angeliki Buku, Robert E Johnson, Louise Prakash, Satya Prakash, Aneel K Aggarwal Ummat A2011
2010 Séverine Cruet-Hennequart, Kathleen Gallagher, Anna M Sokòl, Sangamitra Villalan, Aine M Prendergast, Michael P Carty Cruet-Hennequart S2010
2010 Yong-Sam Jung, Gang Liu, Xinbin Chen Jung YS2010
2010 Mark D Sutton Sutton MD2010
2010 Christian Biertümpfel, Yaofeng Zhao, Yuji Kondo, Santiago Ramón-Maiques, Mark T Gregory, Jae Young Lee, Chikahide Masutani, Alan R Lehmann, Fumio Hanaoka, Wei Wen Yang Biertümpfel C2010
2010 Takayuki Sekimoto, Tsukasa Oda, Franklin Mayca Pozo, Yoshiki Murakumo, Chikahide Masutani, Fumio Hanaoka, Takayuki Yamashita Sekimoto T2010
2010 Tovah A Day, Komariah Palle, Laura R Barkley, Naoko Kakusho, Ying Zou, Satoshi Tateishi, Alain Verreault, Hisao Masai, Cyrus Vaziri Day TA2010
2010 Sayo Kashiwagi, Isao Kuraoka, Yoshie Fujiwara, Kenichi Hitomi, Quen J Cheng, Jill O Fuss, David S Shin, Chikahide Masutani, John A Tainer, Fumio Hanaoka, Shigenori Iwai Kashiwagi S2010
2010 Katarzyna Bebenek, Miguel Garcia-Diaz, Rui-Zhe Zhou, Lawrence F Povirk, Thomas A Kunkel Bebenek K2010
2010 Jessica A Brown, Likui Zhang, Shanen M Sherrer, John-Stephen Taylor, Peter M J Burgers, Zucai Suo Brown JA2010 3-5' exo,5-3' exo,All properties
2009 Dorjbal Dorjsuren, David M Wilson, William A Beard, John P McDonald, Christopher P Austin, Roger Woodgate, Samuel H Wilson, Anton Simeonov Dorjsuren D2009
2009 Simone Sabbioneda, Catherine M Green, Marzena Bienko, Patricia L Kannouche, Ivan Dikic, Alan R Lehmann Sabbioneda S2009
2009 Laurie Rey, Julia M Sidorova, Nadine Puget, François Boudsocq, Denis S F Biard, Raymond J Monnat, Christophe Cazaux, Jean-Sébastien Hoffmann Rey L2009
2009 Kazuya Satou, Mika Hori, Kazuaki Kawai, Hiroshi Kasai, Hideyoshi Harashima, Hiroyuki Kamiya Satou Kazuya2009
2009 Xiao Meng, Yanjiao Zhou, Sufang Zhang, Ernest Y C Lee, David N Frick, Marietta Y W T Lee Meng X2009
2009 Jennifer B Stafford, Robert Lawton Eoff, Albena Kozekova, Carmelo J Rizzo, F Peter Guengerich, Lawrence J Marnett Stafford JB2009
2009 Scott D McCulloch, Robert J Kokoska, Parie Garg, Peter M J Burgers, Thomas A Kunkel McCulloch SD2009
2009 Rémy Bétous, Laurie Rey, Guliang Wang, Marie-Jeanne Pillaire, Nadine Puget, Janick Selves, Denis S F Biard, Kazuo Shin-ya, Karen M Vasquez, Christophe Cazaux, Jean-Sébastien Hoffmann Bétous R2009
2009 Asami Hishiki, Hiroshi Hashimoto, Tomo Hanafusa, Keijiro Kamei, Eiji Ohashi, Toshiyuki Shimizu, Haruo Ohmori, Mamoru Sato Hishiki A2009
2009 Rie Kanao, Fumio Hanaoka, Chikahide Masutani Kanao R2009
2008 Yih-Wen Chen, James E Cleaver, Zafer Hatahet, Richard E Honkanen, Jang-Yang Chang, Yun Yen, Kai-Ming Chou Chen YW2008
2008 Linda J Reha-Krantz Reha-Krantz LJ2008
2008 Narottam Acharya, Jung-Hoon Yoon, Himabindu Gali, Ildiko Unk, Lajos Haracska, Robert E Johnson, Jerard Hurwitz, Louise Prakash, Satya Prakash Acharya N2008
2008 Katsuhiko Hidaka, Masami Yamada, Hiroyuki Kamiya, Chikahide Masutani, Hideyoshi Harashima, Fumio Hanaoka, Takehiko Nohmi Hidaka K2008
2008 Junpei Yamamoto, David Loakes, Chikahide Masutani, Shizu Simmyo, Kumiko Urabe, Fumio Hanaoka, Philipp Holliger, Shigenori Iwai Yamamoto J2008
2008 Patrick P Lestienne, François Boudsocq, Jacques E Bonnet Lestienne PP2008
2008 Laureen C Colis, Paromita Raychaudhury, Ashis K Basu Colis LC2008
2008 Nana Nikolaishvili-Feinberg, G Scott Jenkins, Kathleen R Nevis, Dean P Staus, Cameron O Scarlett, Keziban Unsal-Kaçmaz, William K Kaufmann, Marila Cordeiro-Stone Nikolaishvili-Feinberg N2008 Template lesions,All properties
2008 Scott D McCulloch, Thomas A Kunkel McCulloch SD2008 Frameshift Error Rate,Nucleotide Substitution Rate,All properties
2007 Narottam Acharya, Amrita Brahma, Lajos Haracska, Louise Prakash, Satya Prakash Acharya N2007
2007 Flavia Barone, Scott D McCulloch, Peter Macpherson, Giovanni Maga, Masami Yamada, Takehiko Nohmi, Anna Minoprio, Filomena Mazzei, Thomas A Kunkel, Peter Karran, Margherita Bignami Barone F2007
2007 Hirotomo Nakata, Masayuki Amano, Yasuhiro Koh, Eiichi N Kodama, Guangwei Yang, Christopher M Bailey, Satoru Kohgo, Hiroyuki Hayakawa, Masao Matsuoka, Karen S Anderson, Yung-Chi Cheng, Hiroyuki Mitsuya Nakata H2007
2007 Masatomi Shimizu, Petr Grúz, Hiroyuki Kamiya, Chikahide Masutani, Yan Xu, Yukio Usui, Hiroshi Sugiyama, Hideyoshi Harashima, Fumio Hanaoka, Takehiko Nohmi Shimizu M2007
2007 Jessica A Brown, Wade W Duym, Jason D Fowler, Zucai Suo Brown JA2007
2007 Martha G Bomar, Ming-Tao Pai, Shiou-Ru Tzeng, Shawn Shun-Cheng Li, Pei Zhou Bomar MG2007
2007 Wei Wen Yang, Roger Woodgate Yang WW2007
2006 Scott D McCulloch, Thomas A Kunkel McCulloch SD2006
2006 Jeong-Yun Choi, Goutam Chowdhury, Hong Zang, Karen C Angel, Choua C Vu, Lisa A Peterson, F Peter Guengerich Choi JY2006
2006 Séverine Cruet-Hennequart, Seamus Coyne, Macdara T Glynn, Gregory G Oakley, Michael P Carty Cruet-Hennequart S2006
2006 Bo Zhao, Jianhong Wang, Nicholas E Geacintov, Zhengqiang Wang Zhao B2006
2006 Chiu Hong Lee, Sushil Chandani, Edward L Loechler Lee CH2006
2006 Jeong-Yun Choi, James S Stover, Karen C Angel, Goutam Chowdhury, Carmelo J Rizzo, F Peter Guengerich Choi JY2006
2006 Mayumi S Yuasa, Chikahide Masutani, Akihiko Hirano, Martin A Cohn, Masaru Yamaizumi, Yoshihiro Nakatani, Fumio Hanaoka Yuasa MS2006
2006 Keronninn Moreno Lima-Bessa, Vanessa Chiganças, Anne Stary, Patricia L Kannouche, Alain Sarasin, Melissa Gava Armelini, Jacqueline de Fátima Jacysyn, Gustavo P Amarante-Mendes, Marila Cordeiro-Stone, James E Cleaver, Carlos Frederico Martins Menck Lima-Bessa KM2006
2005 Nicole M King, Nana Nikolaishvili-Feinberg, Miriam F Bryant, Douglas D Luche, Timothy P Heffernan, Dennis A Simpson, Fumio Hanaoka, William K Kaufmann, Marila Cordeiro-Stone King NM2005
2005 Michael J McIlwraith, Michael J Mcllwraith, Alexandra Vaisman, Yilun Liu, Ellen Fanning, Roger Woodgate, Stephen C West McIlwraith MJ2005
2005 Dominic Chiapperino, Mangmang Cai, Jane M Sayer, Haruhiko Yagi, Heiko Kroth, Chikahide Masutani, Fumio Hanaoka, Donald M Jerina, Albert M Cheh Chiapperino D2005
2005 Wei Wen Yang Yang WW2005
2005 Jeong-Yun Choi, F Peter Guengerich Choi JY2005
2005 Takehiko Nohmi, Su-Ryang Kim, Masami Yamada Nohmi T2005
2005 Emmanuele Crespan, Samantha Zanoli, Anastasiya Khandazhinskaya, Igor V Shevelev, Maxim Jasko, Ludmila Alexandrova, Marina Kukhanova, Giuseppina Blanca, Giuseppe Villani, Ulrich Hübscher, Silvio Spadari, Giovanni Maga Crespan E2005
2005 Satya Prakash, Robert E Johnson, Louise Prakash Prakash S2005
2005 Robert E Johnson, Louise Prakash, Satya Prakash Johnson RE2005
2005 William T Wolfle, Robert E Johnson, Irina G Minko, R Stephen Lloyd, Satya Prakash, Louise Prakash Wolfle WT2005
2004 Scott D McCulloch, Robert J Kokoska, Chikahide Masutani, Shigenori Iwai, Fumio Hanaoka, Thomas A Kunkel McCulloch SD2004
2004 Rika Kusumoto, Chikahide Masutani, Shizu Shimmyo, Shigenori Iwai, Fumio Hanaoka Kusumoto R2004
2004 Patricia L Kannouche, Jonathan Wing, Alan R Lehmann Kannouche PL2004
2004 Katuhito Kino, Nobutoshi Ito, Kaoru Sugasawa, Hiroshi Sugiyama, Fumio Hanaoka Kino K2004
2004 Giuseppina Blanca, Giuseppe Villani, Igor V Shevelev, Kristijan Ramadan, Silvio Spadari, Ulrich Hübscher, Giovanni Maga Blanca G2004
2004 Kenji Watanabe, Satoshi Tateishi, Michio Kawasuji, Toshiki Tsurimoto, Hirokazu Inoue, Masaru Yamaizumi Watanabe K2004
2004 Scott D McCulloch, Robert J Kokoska, Thomas A Kunkel McCulloch SD2004
2004 Naomi Suzuki, Manabu Yasui, Y R Santosh Laxmi, Haruo Ohmori, Fumio Hanaoka, Shinya Shibutani Suzuki N2004
2004 Naomi Suzuki, Shinji Itoh, Kinning Poon, Chikahide Masutani, Fumio Hanaoka, Haruo Ohmori, Itsuo Yoshizawa, Shinya Shibutani Suzuki N2004
2004 Kohei Takasawa, Chikahide Masutani, Fumio Hanaoka, Shigenori Iwai Takasawa K2004
2003 Robert J Kokoska, Scott D McCulloch, Thomas A Kunkel Kokoska RJ2003
2003 Robert E Johnson, José Trincao, Aneel K Aggarwal, Satya Prakash, Louise Prakash Johnson RE2003
2003 Thomas A Kunkel, Youri I Pavlov, Katarzyna Bebenek Kunkel TA2003 Full length or truncated,3-5' exo,Nucleotide Substitution Rate,Template lesions,All properties
2003 Eitan Glick, Janice S Chau, Kellie L Vigna, Scott D McCulloch, Elinor T Adman, Thomas A Kunkel, Lawrence A Loeb Glick E2003 KM,Vmax,Associated condition,Template lesions,All properties
2003 M Todd Washington, Robert E Johnson, Louise Prakash, Satya Prakash Washington MT2003
2003 M Todd Washington, William T Wolfle, Thomas E Spratt, Louise Prakash, Satya Prakash Washington MT2003
2003 M Todd Washington, Sandra A Helquist, Eric T Kool, Louise Prakash, Satya Prakash Washington MT2003
2003 Irina G Minko, M Todd Washington, Manorama Kanuri, Louise Prakash, Satya Prakash, R Stephen Lloyd Minko IG2003
2002 Dominic Chiapperino, Heiko Kroth, Irene H Kramarczuk, Jane M Sayer, Chikahide Masutani, Fumio Hanaoka, Donald M Jerina, Albert M Cheh Chiapperino D2002
2002 Ulrich Hubscher, Giovanni Maga, Silvio Spadari Hubscher U2002
2002 François Boudsocq, Hong Ling, Wei Wen Yang, Roger Woodgate Boudsocq F2002
2002 Rika Kusumoto, Chikahide Masutani, Shigenori Iwai, Fumio Hanaoka Kusumoto R2002
2002 Yongqing Zhang, Xiaoming Wu, Dongyu Guo, Olga Rechkoblit, Nicholas E Geacintov, Zhengqiang Wang Zhang Y2002
2002 Lajos Haracska, Louise Prakash, Satya Prakash Haracska L2002
2001 M Todd Washington, Robert E Johnson, Satya Prakash, Louise Prakash Washington MT2001
2001 Patricia J Gearhart, Richard D Wood Gearhart PJ2001 Associated condition,Template lesions,Overall Error Rate,All properties
2001 Isao Kuraoka, P Robins, Chikahide Masutani, Fumio Hanaoka, Didier Gasparutto, Jean Cadet, Richard D Wood, T Lindahl Kuraoka I2001
2001 M Todd Washington, Robert E Johnson, Louise Prakash, Satya Prakash Washington MT2001
2001 Phillip A Furman, J Jeffrey, L L Kiefer, Joy Y Feng, Karen S Anderson, K Borroto-Esoda, E Hill, William C Copeland, Chung K Chu, J P Sommadossi, I Liberman, Raymond F Schinazi, George R Painter Furman PA2001
2001 Eitan Glick, Kellie L Vigna, Lawrence A Loeb Glick E2001
2001 Toshiro Matsuda, Katarzyna Bebenek, Chikahide Masutani, Igor B Rogozin, Fumio Hanaoka, Thomas A Kunkel Matsuda T2001 Cloned or native,Tagged,Tag Name,Full length or truncated,Gap fill,3-5' exo,Nucleotide Substitution Rate,All properties
2001 Katarzyna Bebenek, Toshiro Matsuda, Chikahide Masutani, Fumio Hanaoka, Thomas A Kunkel Bebenek K2001
2001 A J Podlutsky, Irina I Dianova, Vladimir N Podust, Vilhelm A Bohr, Grigory L Dianov Podlutsky AJ2001
2001 Lajos Haracska, Robert E Johnson, Ildiko Unk, B Phillips, Jerard Hurwitz, Louise Prakash, Satya Prakash Haracska L2001
2001 M Todd Washington, Louise Prakash, Satya Prakash Washington MT2001 Processivity,Kd,kcat,Vmax,All properties
2000 K Nagasawa, K Kitamura, Akira Yasui, Y Nimura, Kyoji Ikeda, Midori Hirai, Akio Matsukage, Makoto Nakanishi Nagasawa K2000
2000 Toshiro Matsuda, Katarzyna Bebenek, Chikahide Masutani, Fumio Hanaoka, Thomas A Kunkel Matsuda T2000 3-5' exo,All properties
2000 Robert E Johnson, M Todd Washington, Satya Prakash, Louise Prakash Johnson RE2000
2000 Agnès Tissier, John P McDonald, Ekaterina G Frank, Roger Woodgate Tissier A2000
2000 Eiji Ohashi, Katarzyna Bebenek, Toshiro Matsuda, William J Feaver, Valerie L Gerlach, Errol C Friedberg, Haruo Ohmori, Thomas A Kunkel Ohashi E2000 Nucleotide Substitution Rate,All properties
2000 Yongqing Zhang, Fenghua Yuan, Xiaoming Wu, Olga Rechkoblit, John-Stephen Taylor, Nicholas E Geacintov, Zhengqiang Wang Zhang Y2000
2000 Lajos Haracska, Satya Prakash, Louise Prakash Haracska L2000
2000 Chikahide Masutani, Rika Kusumoto, Shigenori Iwai, Fumio Hanaoka Masutani C2000
2000 Satya Prakash, Robert E Johnson, M Todd Washington, Lajos Haracska, Christine M Kondratick, Louise Prakash Prakash S2000
2000 Alexandra Vaisman, Chikahide Masutani, Fumio Hanaoka, Stephen G Chaney Vaisman A2000
1999 E Efrati, G Tocco, R Eritja, Samuel H Wilson, Myron F Goodman Efrati E1999
1999 T A Winters, P S Russell, M Kohli, M E Dar, R D Neumann, T J Jorgensen Winters TA1999
1999 J M de Muys, H Gourdeau, N Nguyen-Ba, D L Taylor, P S Ahmed, T Mansour, C Locas, N Richard, Mark A. Wainberg, R F Rando de Muys JM1999
1999 N B Reuven, Gali Arad, Ayelet Maor-Shoshani, Zvi Livneh Reuven NB1999
1999 Chikahide Masutani, Rika Kusumoto, Ayumi Yamada, N Dohmae, Masayuki Yokoi, M Yuasa, M Araki, Shigenori Iwai, K Takio, Fumio Hanaoka Masutani C1999
1999 Farida S Sharief, P J Vojta, P A Ropp, William C Copeland Sharief FS1999
1997 E Efrati, G Tocco, R Eritja, Samuel H Wilson, Myron F Goodman Efrati E1997
1995 Federico Focher, Giovanni Maga, A Bendiscioli, M Capobianco, F Colonna, A Garbesi, Silvio Spadari Focher F1995
1995 R R Vyas, A K Basu Vyas RR1995
1993 M S Chen, R T Suttmann, E Papp, P D Cannon, M J McRoberts, C Bach, William C Copeland, Teresa S-F Wang Chen MS1993
1992 William C Copeland, M S Chen, Teresa S-F Wang Copeland WC1992
1991 K B Frank, G J Noll, E V Connell, I S Sim Frank KB1991
1989 J E Reardon Reardon JE1989
1988 H Nakane, Jan Balzarini, Erik De Clercq, K Ono Nakane H1988
Protein sequence:
DNA sequence:
Name 3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
Pol eta Y52F No (1) No (1)
Pol eta Y52D
Pol eta Y52H
Pol eta Y52E No (1) No (1)
Pol eta Y52A No (1) No (1)
Human Pol eta D652A
All Polymerases | 41 Results

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