Synthetic analogues of the manzamenones and plakoridines which inhibit DNA polymerase.

Doncaster JR, Etchells LL, Kershaw NM, Nakamura R, Ryan H, Takeuchi R, Sakaguchi K, Sardarian A, Whitehead RC
Bioorganic & medicinal chemistry letters (2006), Volume 16, Page 2877
PubMed entry Publisher's site

Abstract:

An array of novel analogues of the marine oxylipins, the manzamenones ...
An array of novel analogues of the marine oxylipins, the manzamenones and plakoridines, have been prepared in divergent fashion using an approach modelled on a biogenetic theory. Many of the target compounds show potent inhibition of DNA polymerases alpha and beta and human terminal deoxynucleotidyl transferase (TdT).

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