Structural insights into DNA polymerase beta fidelity: hold tight if you want it right.

Beard WA, Wilson SH
Chemistry & biology (1998), Volume 5, Page R7
PubMed entry

Abstract:

DNA polymerases must select and incorporate the correct ...
DNA polymerases must select and incorporate the correct deoxynucleoside 5'-triphosphate from a pool of structurally similar molecules. The structural and kinetic characterization of DNA polymerase beta indicates that this polymerase must stabilize the templating base to achieve efficient polymerization with high fidelity.

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