Beard WA

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Title	Authors	Year	Journal
A review of recent experiments on step-to-step "hand-off" of the DNA intermediates in mammalian base excision repair pathways.	Beard WA		Molekuliarnaia biologiia
Understanding the loss-of-function in a triple missense mutant of DNA polymerase β found in prostate cancer.	Beard WA	2013	International journal of oncology
Amino acid substitution in the active site of DNA polymerase β explains the energy barrier of the nucleotidyl transfer reaction.	Beard WA	2013	Journal of the American Chemical Society
Insights into the Conformation of Aminofluorene-dG Adduct in a DNA Polymerase Active Site.	Beard WA	2013	The Journal of biological chemistry
Observing a DNA polymerase choose right from wrong.	Beard WA	2013	Cell
Inhibition of HIV-1 Reverse Transcriptase-Catalyzed Synthesis by Intercalated DNA Benzo[a]Pyrene 7,8-Dihydrodiol-9,10-Epoxide Adducts.	Beard WA	2013	PloS one
DNA Polymerase β Gap-filling Translesion DNA Synthesis.	Beard WA	2012	Chemical research in toxicology
DNA polymerase minor groove interactions modulate mutagenic bypass of a templating 8-oxoguanine lesion.	Beard WA	2012	Nucleic acids research
Effect of β,γ-CHF- and β,γ-CHCl-dGTP Halogen Atom Stereochemistry on the Transition State of DNA Polymerase β	Beard WA	2012	Biochemistry
Structures of dNTP Intermediate States during DNA Polymerase Active Site Assembly.	Beard WA	2012	Structure (London, England : 1993)
Perspective: pre-chemistry conformational changes in DNA polymerase mechanisms.	Beard WA	2012	Theoretical chemistry accounts
Metal-induced DNA translocation leads to DNA polymerase conformational activation.	Beard WA	2011	Nucleic acids research
Binary complex crystal structure of DNA polymerase β reveals multiple conformations of the templating 8-oxoguanine lesion.	Beard WA	2011	Proceedings of the National Academy of Sciences of the United States of America
Molecular insights into DNA polymerase deterrents for ribonucleotide insertion.	Beard WA	2011	The Journal of biological chemistry
DNA polymerase beta ribonucleotide discrimination: insertion, misinsertion, extension, and coding.	Beard WA	2010	The Journal of biological chemistry
DNA polymerase structure-based insight on the mutagenic properties of 8-oxoguanine.	Beard WA	2010	Mutation research
Substrate channeling in mammalian base excision repair pathways: passing the baton.	Beard WA	2010	The Journal of biological chemistry
Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid.	Beard WA	2010	Proceedings of the National Academy of Sciences of the United States of America
Halogenated beta,gamma-methylene- and ethylidene-dGTP-DNA ternary complexes with DNA polymerase beta: structural evidence for stereospecific binding of the fluoromethylene analogues.	Beard WA	2010	Journal of the American Chemical Society
Mutagenic conformation of 8-oxo-7,8-dihydro-2'-dGTP in the confines of a DNA polymerase active site.	Beard WA	2010	Nature structural & molecular biology
Base excision repair and design of small molecule inhibitors of human DNA polymerase beta.	Beard WA	2010	Cell Mol Life Sci
A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases.	Beard WA	2009	Nucleic acids research
DNA polymerase beta and PARP activities in base excision repair in living cells.	Beard WA	2009	DNA repair
Alpha,beta-difluoromethylene deoxynucleoside 5'-triphosphates: a convenient synthesis of useful probes for DNA polymerase beta structure and function.	Beard WA	2009	Org Lett
DNA polymerase beta substrate specificity: side chain modulation of the "A-rule".	Beard WA	2009	The Journal of biological chemistry
Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability studies of novel 2'-deoxycyclonucleosides, 3,5'-cyclo-dG, and 2,5'-cyclo-dT.	Beard WA	2008	J Med Chem
DNA polymerase beta fidelity: halomethylene-modified leaving groups in pre-steady-state kinetic analysis reveal differences at the chemical transition state.	Beard WA	2008	Biochemistry
Exploring the role of large conformational changes in the fidelity of DNA polymerase beta.	Beard WA	2008	Proteins
Incorrect nucleotide insertion at the active site of a G:A mismatch catalyzed by DNA polymerase beta.	Beard WA	2008	Proceedings of the National Academy of Sciences of the United States of America
Structures of DNA polymerase beta with active-site mismatches suggest a transient abasic site intermediate during misincorporation.	Beard WA	2008	Molecular cell
Modifying the beta,gamma leaving-group bridging oxygen alters nucleotide incorporation efficiency, fidelity, and the catalytic mechanism of DNA polymerase beta.	Beard WA	2007	Biochemistry
Differing conformational pathways before and after chemistry for insertion of dATP versus dCTP opposite 8-oxoG in DNA polymerase beta.	Beard WA	2007	Biophys J
The X family portrait: structural insights into biological functions of X family polymerases.	Beard WA	2007	DNA repair
Coordination of steps in single-nucleotide base excision repair mediated by apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta.	Beard WA	2007	The Journal of biological chemistry
Magnesium-cationic dummy atom molecules enhance representation of DNA polymerase beta in molecular dynamics simulations: improved accuracy in studies of structural features and mutational effects.	Beard WA	2007	Journal of molecular biology
(R)-beta,gamma-fluoromethylene-dGTP-DNA ternary complex with DNA polymerase beta.	Beard WA	2007	Journal of the American Chemical Society
Regulation of DNA repair fidelity by molecular checkpoints: "gates" in DNA polymerase beta's substrate selection.	Beard WA	2006	Biochemistry
Determination of lysine pK values using [5-13C]lysine: application to the lyase domain of DNA Pol beta.	Beard WA	2006	Journal of the American Chemical Society
Structure of DNA polymerase beta with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features.	Beard WA	2006	Proceedings of the National Academy of Sciences of the United States of America
Energy analysis of chemistry for correct insertion by DNA polymerase beta.	Beard WA	2006	Proceedings of the National Academy of Sciences of the United States of America
Magnesium-induced assembly of a complete DNA polymerase catalytic complex.	Beard WA	2006	Structure (London, England : 1993)
Structure and mechanism of DNA polymerase Beta.	Beard WA	2006	Chem Rev
Activities and mechanism of DNA polymerase beta.	Beard WA	2006	Methods in enzymology
DNA polymerase beta and flap endonuclease 1 enzymatic specificities sustain DNA synthesis for long patch base excision repair.	Beard WA	2005	The Journal of biological chemistry
DNA polymerase lambda mediates a back-up base excision repair activity in extracts of mouse embryonic fibroblasts.	Beard WA	2005	The Journal of biological chemistry
Syn-full behavior by T7 DNA polymerase.	Beard WA	2005	Structure (London, England : 1993)
A thymine isostere in the templating position disrupts assembly of the closed DNA polymerase beta ternary complex.	Beard WA	2005	Biochemistry
Mismatch-induced conformational distortions in polymerase beta support an induced-fit mechanism for fidelity.	Beard WA	2005	Biochemistry
Nucleotide-induced DNA polymerase active site motions accommodating a mutagenic DNA intermediate.	Beard WA	2005	Structure (London, England : 1993)
Structural insight into the DNA polymerase beta deoxyribose phosphate lyase mechanism.	Beard WA	2005	DNA repair
High-level expression and purification of untagged and histidine-tagged HIV-1 reverse transcriptase.	Beard WA	2004	Protein expression and purification
Dynamic characterization of a DNA repair enzyme: NMR studies of [methyl-13C]methionine-labeled DNA polymerase beta.	Beard WA	2004	Biochemistry
Critical role of magnesium ions in DNA polymerase beta's closing and active site assembly.	Beard WA	2004	Journal of the American Chemical Society
Influence of DNA structure on DNA polymerase beta active site function: extension of mutagenic DNA intermediates.	Beard WA	2004	The Journal of biological chemistry
Highly organized but pliant active site of DNA polymerase beta: compensatory mechanisms in mutant enzymes revealed by dynamics simulations and energy analyses.	Beard WA	2004	Biophys J
Structural insights into DNA polymerase beta deterrents for misincorporation support an induced-fit mechanism for fidelity.	Beard WA	2004	Structure (London, England : 1993)
Localization of the deoxyribose phosphate lyase active site in human DNA polymerase iota by controlled proteolysis.	Beard WA	2003	The Journal of biological chemistry
Rapid segmental and subdomain motions of DNA polymerase beta.	Beard WA	2003	The Journal of biological chemistry
Structure of DNA polymerase beta with the mutagenic DNA lesion 8-oxodeoxyguanine reveals structural insights into its coding potential.	Beard WA	2003	Structure (London, England : 1993)
Structural insights into the origins of DNA polymerase fidelity.	Beard WA	2003	Structure (London, England : 1993)
Efficiency of correct nucleotide insertion governs DNA polymerase fidelity.	Beard WA	2002	The Journal of biological chemistry
Loss of DNA polymerase beta stacking interactions with templating purines, but not pyrimidines, alters catalytic efficiency and fidelity.	Beard WA	2002	The Journal of biological chemistry
Local deformations revealed by dynamics simulations of DNA polymerase Beta with DNA mismatches at the primer terminus.	Beard WA	2002	Journal of molecular biology
Polymerase beta simulations suggest that Arg258 rotation is a slow step rather than large subdomain motions per se.	Beard WA	2002	Journal of molecular biology
DNA lesion bypass polymerases open up.	Beard WA	2001	Structure (London, England : 1993)
DNA structure and aspartate 276 influence nucleotide binding to human DNA polymerase beta. Implication for the identity of the rate-limiting conformational change.	Beard WA	2001	The Journal of biological chemistry
Vertical-scanning mutagenesis of a critical tryptophan in the "minor groove binding track" of HIV-1 reverse transcriptase. Major groove DNA adducts identify specific protein interactions in the minor groove.	Beard WA	2000	The Journal of biological chemistry
DNA polymerase beta and mammalian base excision repair.	Beard WA	2000	Cold Spring Harbor symposia on quantitative biology
Structural design of a eukaryotic DNA repair polymerase: DNA polymerase beta.	Beard WA	2000	Mutation research
Minor groove interactions at the DNA polymerase beta active site modulate single-base deletion error rates.	Beard WA	2000	The Journal of biological chemistry
Residues in the alphaH and alphaI helices of the HIV-1 reverse transcriptase thumb subdomain required for the specificity of RNase H-catalyzed removal of the polypurine tract primer.	Beard WA	1999	The Journal of biological chemistry
Base substitution specificity of DNA polymerase beta depends on interactions in the DNA minor groove.	Beard WA	1999	The Journal of biological chemistry
Uniquely altered DNA replication fidelity conferred by an amino acid change in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase.	Beard WA	1999	The Journal of biological chemistry
The fidelity of DNA polymerase beta during distributive and processive DNA synthesis.	Beard WA	1999	The Journal of biological chemistry
Interactions between DNA polymerase beta and the major covalent adduct of the carcinogen (+)-anti-benzo[a]pyrene diol epoxide with DNA at a primer-template junction.	Beard WA	1998	Biochemistry
Vertical-scanning mutagenesis of a critical tryptophan in the minor groove binding track of HIV-1 reverse transcriptase. Molecular nature of polymerase-nucleic acid interactions.	Beard WA	1998	The Journal of biological chemistry
Human DNA polymerase beta deoxyribose phosphate lyase. Substrate specificity and catalytic mechanism.	Beard WA	1998	The Journal of biological chemistry
Functional analysis of the amino-terminal 8-kDa domain of DNA polymerase beta as revealed by site-directed mutagenesis. DNA binding and 5'-deoxyribose phosphate lyase activities.	Beard WA	1998	The Journal of biological chemistry
Structural insights into DNA polymerase beta fidelity: hold tight if you want it right.	Beard WA	1998	Chemistry & biology
Mammalian abasic site base excision repair. Identification of the reaction sequence and rate-determining steps.	Beard WA	1998	The Journal of biological chemistry
Subunits of human replication protein A are crosslinked by photoreactive primers synthesized by DNA polymerases.	Beard WA	1998	Nucleic acids research
A minor groove binding track in reverse transcriptase.	Beard WA	1997	Nat Struct Biol
Probing structure/function relationships of HIV-1 reverse transcriptase with styrene oxide N2-guanine adducts.	Beard WA	1997	The Journal of biological chemistry
dNTP binding to HIV-1 reverse transcriptase and mammalian DNA polymerase beta as revealed by affinity labeling with a photoreactive dNTP analog.	Beard WA	1996	The Journal of biological chemistry
Enzyme-DNA interactions required for efficient nucleotide incorporation and discrimination in human DNA polymerase beta.	Beard WA	1996	The Journal of biological chemistry
dNTP binding site in rat DNA polymerase beta revealed by controlled proteolysis and azido photoprobe cross-linking.	Beard WA	1996	Biochemistry
Role of the "helix clamp" in HIV-1 reverse transcriptase catalytic cycling as revealed by alanine-scanning mutagenesis.	Beard WA	1996	The Journal of biological chemistry
Specific inhibition of DNA polymerase beta by its 14 kDa domain: role of single- and double-stranded DNA binding and 5'-phosphate recognition.	Beard WA	1995	Nucleic acids research
Purification and domain-mapping of mammalian DNA polymerase beta.	Beard WA	1995	Methods in enzymology
Human immunodeficiency virus type 1 reverse transcriptase. 3'-Azidodeoxythymidine 5'-triphosphate inhibition indicates two-step binding for template-primer.	Beard WA	1995	The Journal of biological chemistry
Reduced frameshift fidelity and processivity of HIV-1 reverse transcriptase mutants containing alanine substitutions in helix H of the thumb subdomain.	Beard WA	1995	The Journal of biological chemistry
DNA damage-induced transcriptional activation of a human DNA polymerase beta chimeric promoter: recruitment of preinitiation complex in vitro by ATF/CREB.	Beard WA	1995	Biochemistry
Structure/function studies of human immunodeficiency virus type 1 reverse transcriptase. Alanine scanning mutagenesis of an alpha-helix in the thumb subdomain.	Beard WA	1994	The Journal of biological chemistry
Site-directed mutagenesis of HIV reverse transcriptase to probe enzyme processivity and drug binding.	Beard WA	1994	Current opinion in biotechnology
Studies of gapped DNA substrate binding by mammalian DNA polymerase beta. Dependence on 5'-phosphate group.	Beard WA	1994	The Journal of biological chemistry
Expression and purification of the HIV-1 reverse transcriptase using the baculovirus expression vector system.	Beard WA	1993	Protein expression and purification
HIV-1 reverse transcriptase: inhibition by 2',5'-oligoadenylates.	Beard WA	1993	Biochemistry
Structure/function studies of HIV-1(1) reverse transcriptase: dimerization-defective mutant L289K.	Beard WA	1993	Biochemistry
Kinetic analysis of template.primer interactions with recombinant forms of HIV-1 reverse transcriptase.	Beard WA	1993	Biochemistry

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Beard WA

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