The separated enantiomers of 2'-deoxy-3'-thiacytidine (BCH 189) both inhibit human immunodeficiency virus replication in vitro.

Coates JA, Cammack N, Jenkinson HJ, Mutton IM, Pearson BA, Storer R, Cameron JM, Penn CR
Antimicrob Agents Chemother (1992), Volume 36, Page 202
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Abstract:

Racemic 2'-deoxy-3'-thiacytidine (BCH 189) is a dideoxycytidine analog ...
Racemic 2'-deoxy-3'-thiacytidine (BCH 189) is a dideoxycytidine analog having a sulfur atom in place of the 3' carbon. The enantiomers of BCH 189 have been resolved and found to be equipotent in antiviral activity against human immunodeficiency virus types 1 and 2. However, the (-)-enantiomer (3TC) is considerably less cytotoxic than the (+)-enantiomer.

Polymerases:

HIV RT

Topics:

Modulators/Inhibitors, Health/Disease, Nucleotide Incorporation

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