Mechanisms of HIV-1 nucleoside reverse transcriptase inhibitor resistance: is it all figured out?

Naeger LK, Miller MD
Curr Opin Investig Drugs (2001), Volume 2, Page 335
PubMed entry

Abstract:

The mechanistic basis for some examples of HIV-1 NRTI-resistance can ...
The mechanistic basis for some examples of HIV-1 NRTI-resistance can be examined using altered incorporation of nucleoside analogs and surveying what is known about the more recently described mechanisms of chain-terminator removal. The complexity of these resistance mechanisms and the interplay with other factors that contribute to NRT1 resistance are only just beginning to be appreciated.

Polymerases:

HIV RT

Topics:

Health/Disease

Status:

new topics/pols set partial results complete validated

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