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Miller MD

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Publications:

Title Authors Year Journal
Mechanism of resistance to GS-9148 conferred by the Q151L mutation in HIV-1 reverse transcriptase. Miller MD 2011 Antimicrobial agents and chemotherapy
Substituted tetrahydroquinolines as potent allosteric inhibitors of reverse transcriptase and its key mutants. Miller MD 2009 Bioorganic & medicinal chemistry letters
Structural basis for the role of the K65R mutation in HIV-1 reverse transcriptase polymerization, excision antagonism, and tenofovir resistance. Miller MD 2009 The Journal of biological chemistry
The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations. Miller MD 2008 Bioorganic & medicinal chemistry letters
Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs). Miller MD 2008 Bioorganic & medicinal chemistry letters
Discovery of 3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5 -chlorobenzonitrile (MK-4965): a potent, orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitor with improved potency against key mutant viruses. Miller MD 2008 J Med Chem
Effects of the translocation status of human immunodeficiency virus type 1 reverse transcriptase on the efficiency of excision of tenofovir. Miller MD 2007 Antimicrob Agents Chemother
The K65R reverse transcriptase mutation in HIV-1 reverses the excision phenotype of zidovudine resistance mutations. Miller MD 2006 Antivir Ther
A combination of decreased NRTI incorporation and decreased excision determines the resistance profile of HIV-1 K65R RT. Miller MD 2005 Aids
Dissecting the effects of DNA polymerase and ribonuclease H inhibitor combinations on HIV-1 reverse-transcriptase activities. Miller MD 2005 Biochemistry
Mechanistic basis for reduced viral and enzymatic fitness of HIV-1 reverse transcriptase containing both K65R and M184V mutations. Miller MD 2004 The Journal of biological chemistry
Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir. Miller MD 2004 Nature structural & molecular biology
Genotypic and phenotypic predictors of the magnitude of response to tenofovir disoproxil fumarate treatment in antiretroviral-experienced patients. Miller MD 2004 J Infect Dis
Molecular mechanisms of tenofovir resistance conferred by human immunodeficiency virus type 1 reverse transcriptase containing a diserine insertion after residue 69 and multiple thymidine analog-associated mutations. Miller MD 2004 Antimicrob Agents Chemother
Inhibition of HIV-1 ribonuclease H by a novel diketo acid, 4-[5-(benzoylamino)thien-2-yl]-2,4-dioxobutanoic acid. Miller MD 2003 The Journal of biological chemistry
The hepatitis B virus polymerase mutation rtV173L is selected during lamivudine therapy and enhances viral replication in vitro. Miller MD 2003 Journal of virology
ATP-dependent removal of nucleoside reverse transcriptase inhibitors by human immunodeficiency virus type 1 reverse transcriptase. Miller MD 2002 Antimicrob Agents Chemother
Molecular mechanisms of resistance to human immunodeficiency virus type 1 with reverse transcriptase mutations K65R and K65R+M184V and their effects on enzyme function and viral replication capacity. Miller MD 2002 Antimicrob Agents Chemother
Mechanisms of HIV-1 nucleoside reverse transcriptase inhibitor resistance: is it all figured out? Miller MD 2001 Curr Opin Investig Drugs
In vitro selection and characterization of HIV-1 with reduced susceptibility to PMPA. Miller MD 1999 Antivir Ther
Human immunodeficiency virus type 1 expressing the lamivudine-associated M184V mutation in reverse transcriptase shows increased susceptibility to adefovir and decreased replication capability in vitro. Miller MD 1999 J Infect Dis
Human immunodeficiency virus type 1 reverse transcriptase expressing the K70E mutation exhibits a decrease in specific activity and processivity. Miller MD 1998 Molecular pharmacology

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