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Miller MD

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Publications:

Title Authors Year Journal
Mechanism of resistance to GS-9148 conferred by the Q151L mutation in HIV-1 reverse transcriptase. Miller MD 2011 Antimicrobial agents and chemotherapy
Structural basis for the role of the K65R mutation in HIV-1 reverse transcriptase polymerization, excision antagonism, and tenofovir resistance. Miller MD 2009 The Journal of biological chemistry
Substituted tetrahydroquinolines as potent allosteric inhibitors of reverse transcriptase and its key mutants. Miller MD 2009 Bioorganic & medicinal chemistry letters
The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations. Miller MD 2008 Bioorganic & medicinal chemistry letters
Discovery of 3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5 -chlorobenzonitrile (MK-4965): a potent, orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitor with improved potency against key mutant viruses. Miller MD 2008 J Med Chem
Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs). Miller MD 2008 Bioorganic & medicinal chemistry letters
Effects of the translocation status of human immunodeficiency virus type 1 reverse transcriptase on the efficiency of excision of tenofovir. Miller MD 2007 Antimicrob Agents Chemother
The K65R reverse transcriptase mutation in HIV-1 reverses the excision phenotype of zidovudine resistance mutations. Miller MD 2006 Antivir Ther
A combination of decreased NRTI incorporation and decreased excision determines the resistance profile of HIV-1 K65R RT. Miller MD 2005 Aids
Dissecting the effects of DNA polymerase and ribonuclease H inhibitor combinations on HIV-1 reverse-transcriptase activities. Miller MD 2005 Biochemistry
Molecular mechanisms of tenofovir resistance conferred by human immunodeficiency virus type 1 reverse transcriptase containing a diserine insertion after residue 69 and multiple thymidine analog-associated mutations. Miller MD 2004 Antimicrob Agents Chemother
Mechanistic basis for reduced viral and enzymatic fitness of HIV-1 reverse transcriptase containing both K65R and M184V mutations. Miller MD 2004 The Journal of biological chemistry
Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir. Miller MD 2004 Nature structural & molecular biology
Genotypic and phenotypic predictors of the magnitude of response to tenofovir disoproxil fumarate treatment in antiretroviral-experienced patients. Miller MD 2004 J Infect Dis
Inhibition of HIV-1 ribonuclease H by a novel diketo acid, 4-[5-(benzoylamino)thien-2-yl]-2,4-dioxobutanoic acid. Miller MD 2003 The Journal of biological chemistry
The hepatitis B virus polymerase mutation rtV173L is selected during lamivudine therapy and enhances viral replication in vitro. Miller MD 2003 Journal of virology
ATP-dependent removal of nucleoside reverse transcriptase inhibitors by human immunodeficiency virus type 1 reverse transcriptase. Miller MD 2002 Antimicrob Agents Chemother
Molecular mechanisms of resistance to human immunodeficiency virus type 1 with reverse transcriptase mutations K65R and K65R+M184V and their effects on enzyme function and viral replication capacity. Miller MD 2002 Antimicrob Agents Chemother
Mechanisms of HIV-1 nucleoside reverse transcriptase inhibitor resistance: is it all figured out? Miller MD 2001 Curr Opin Investig Drugs
In vitro selection and characterization of HIV-1 with reduced susceptibility to PMPA. Miller MD 1999 Antivir Ther
Human immunodeficiency virus type 1 expressing the lamivudine-associated M184V mutation in reverse transcriptase shows increased susceptibility to adefovir and decreased replication capability in vitro. Miller MD 1999 J Infect Dis
Human immunodeficiency virus type 1 reverse transcriptase expressing the K70E mutation exhibits a decrease in specific activity and processivity. Miller MD 1998 Molecular pharmacology
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