Backbone assignment of the catalytic core of a Y-family DNA polymerase.

Abstract:

Sulfolobus solfataricus DNA polymerase IV (Dpo4), a model Y-family DNA polymerase, bypasses DNA lesions. Here, we report the assignments for the backbone nitrogen, carbon, and amide proton NMR signals of Dpo4's catalytic core consisting of the finger, palm, and thumb domains. Our work provides the basis for further NMR spectroscopic studies of the interactions among Dpo4, DNA, and an incoming nucleotide.

Polymerases:

Topics:

Structure and Structure/Function

Status:

new topics/pols set partial results complete validated

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