2-Aminopurine-induced mutagenesis in T4 bacteriophage: a model relating mutation frequency to 2-aminopurine incorporation in DNA.

Abstract:

We measured the in vivo incorporation of 2-aminopurine into DNA of T4 ...

Polymerases:

Topics:

Mutational Analysis, Nucleotide Analogs / Template Lesions, Fidelity, Nucleotide Incorporation, Exonuclease Activity

One line summary:

Mutator polymerases undergo a one-step proofreading process, while antimutator polymerases undergo two.

Status:

new topics/pols set partial results complete validated

Results:

Polymerase Reference Property Result Context
T4 A89TD363N 2-Aminopurine-induced mutagenesis in T4 bacteriophage: a model relating mutation frequency to 2-aminopurine incorporation in DNA. Nucleotide Substitution Rate 100 Mutation frequency (relative to WT) Technique: T4 rII 199oc reversion assay (Spontaneous)
T4 A89TD363N 2-Aminopurine-induced mutagenesis in T4 bacteriophage: a model relating mutation frequency to 2-aminopurine incorporation in DNA. Nucleotide Substitution Rate 5 Mutation frequency (relative to WT) Technique: T4 rII 199oc reversion assay (AP-induced)
T4 A89TD363N 2-Aminopurine-induced mutagenesis in T4 bacteriophage: a model relating mutation frequency to 2-aminopurine incorporation in DNA. Nucleotide Substitution Rate 3.8 Mutation frequency (relative to WT) Technique: T4 rII 199oc reversion assay (dCMP-AP mismatch)
T4 A737V 2-Aminopurine-induced mutagenesis in T4 bacteriophage: a model relating mutation frequency to 2-aminopurine incorporation in DNA. Nucleotide Substitution Rate 0.002 Mutation frequency (relative to WT) Technique: T4 rII 199oc reversion assay (spontaneous)
T4 A737V 2-Aminopurine-induced mutagenesis in T4 bacteriophage: a model relating mutation frequency to 2-aminopurine incorporation in DNA. Nucleotide Substitution Rate 0.0025 Mutation frequency (relative to WT) Technique: T4 rII 199oc reversion assay (AP-induced)
T4 A737V 2-Aminopurine-induced mutagenesis in T4 bacteriophage: a model relating mutation frequency to 2-aminopurine incorporation in DNA. Nucleotide Substitution Rate 0.01 Mutation frequency (relative to WT) Technique: T4 rII 199oc reversion assay (dCMP-AP mismatch)

Entry validated by: