Bypass specialists operate together.

Takata Kei-ichi, Wood RichardD
The EMBO journal (2009), Volume 28, Page 313
PubMed entry Full article text Publisher's site

Abstract:

New experiments show that different combinations of translesion DNA ...
New experiments show that different combinations of translesion DNA polymerases act to bypass lesions in mammalian cells, depending on the type of DNA damage. Bypass of most lesions tested was dependent on REV3L (pol zeta) and at least one additional DNA polymerase. The data fit a model whereby DNA polymerases work sequentially to bypass adducts in DNA.

Polymerases:

Human Pol zeta

Topics:

Health/Disease

Status:

new topics/pols set partial results complete validated

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