Synthesis of pyrimidine and quinolone conjugates as a scaffold for dual inhibitors of HIV reverse transcriptase and integrase.

Wang Z, Vince R
Bioorganic & medicinal chemistry letters (2008), Volume 18, Page 1293
PubMed entry Publisher's site

Abstract:

A series of conjugates combining a pyrimidine and a quinolone moiety ...
A series of conjugates combining a pyrimidine and a quinolone moiety were designed and synthesized. The assay results show that these compounds demonstrate both anti-RT activity and anti-IN activity and therefore provide a useful scaffold for identifying inhibitors with balanced dual activities.

Polymerases:

HIV RT

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