Mechanism of interaction of novel indolylarylsulfone derivatives with K103N and Y181I mutant HIV-1 reverse transcriptase in complex with its substrates.

Samuele A, Bisi S, Kataropoulou A, La Regina G, Piscitelli F, Gatti V, Silvestri R, Maga G
Antiviral chemistry & chemotherapy (2011), Volume 22, Page 107
PubMed entry Publisher's site

Abstract:

Novel indolylarylsulfones (IASs), designed through rational ...
Novel indolylarylsulfones (IASs), designed through rational structure-based molecular modelling and docking approaches, have been recently characterized as effective inhibitors of the wild-type and drug-resistant mutant HIV-1 reverse transcriptase (RT).

Polymerases:

HIV RT

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