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Maga G

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Publications:

Title Authors Year Journal
Structural determinants of HIV-1 reverse transcriptase stereoselectivity towards (beta)-L-deoxy- and dideoxy-pyrimidine nucleoside triphosphates: molecular basis for the combination of L-dideoxynucleoside analogs with non-nucleoside inhibitors in anti HIV chemotherapy. Maga G Nucleosides & nucleotides
Structure-based pharmacophore identification of new chemical scaffolds as non-nucleoside reverse transcriptase inhibitors. Maga G Journal of chemical information and modeling
DNA polymerase δ-interacting protein 2 is a processivity factor for DNA polymerase λ during 8-oxo-7,8-dihydroguanine bypass. Maga G 2013 Proceedings of the National Academy of Sciences of the United States of America
New Nitrogen Containing Substituents at the Indole-2-carboxamide Yield High Potent and Broad Spectrum Indolylarylsulfone HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors. Maga G 2012 Journal of medicinal chemistry
Synthesis, Biological Activity, and ADME Properties of Novel S-DABOs/N-DABOs as HIV Reverse Transcriptase Inhibitors. Maga G 2012 ChemMedChem
2-(Alkyl/Aryl)Amino-6-Benzylpyrimidin-4(3H)-ones as Inhibitors of Wild-Type and Mutant HIV-1: Enantioselectivity Studies. Maga G 2012 Journal of medicinal chemistry
Human DNA polymerase β, but not λ, can bypass a 2-deoxyribonolactone lesion together with proliferating cell nuclear antigen. Maga G 2012 ACS chemical biology
Silencing of human DNA polymerase λ causes replication stress and is synthetically lethal with an impaired S phase checkpoint. Maga G 2012 Nucleic acids research
Indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: new cyclic substituents at indole-2-carboxamide. Maga G 2011 Journal of medicinal chemistry
Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants. Maga G 2011 Bioorganic & medicinal chemistry letters
Diarylpyrimidine-dihydrobenzyloxopyrimidine hybrids: new, wide-spectrum anti-HIV-1 agents active at (sub)-nanomolar level. Maga G 2011 Journal of medicinal chemistry
A new proofreading mechanism for lesion bypass by DNA polymerase-λ Maga G 2011 EMBO reports
Mechanism of interaction of novel indolylarylsulfone derivatives with K103N and Y181I mutant HIV-1 reverse transcriptase in complex with its substrates. Maga G 2011 Antiviral chemistry & chemotherapy
Oxidative DNA damage bypass in Arabidopsis thaliana requires DNA polymerase λ and proliferating cell nuclear antigen 2. Maga G 2011 The Plant cell
DNA replication and repair bypass machines. Maga G 2011 Current opinion in chemical biology
Novel 1,3-dihydro-benzimidazol-2-ones and their analogues as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. Maga G 2010 Bioorganic & medicinal chemistry
Slow binding-tight binding interaction between benzimidazol-2-one inhibitors and HIV-1 reverse transcriptase containing the lysine 103 to asparagine mutation. Maga G 2010 Antiviral research
Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action. Maga G 2010 Angew Chem Int Ed Engl
HIV-1 RT Inhibitors with a Novel Mechanism of Action: NNRTIs that Compete with the Nucleotide Substrate. Maga G 2010 Viruses
DNA polymerases beta and lambda bypass thymine glycol in gapped DNA structures. Maga G 2010 Biochemistry
Discovery of chiral cyclopropyl dihydro-alkylthio-benzyl-oxopyrimidine (S-DABO) derivatives as potent HIV-1 reverse transcriptase inhibitors with high activity against clinically relevant mutants. Maga G 2009 Journal of medicinal chemistry
The resveratrol analogue 4,4'-dihydroxy-trans-stilbene inhibits cell proliferation with higher efficiency but different mechanism from resveratrol. Maga G 2009 The international journal of biochemistry & cell biology
The block of DNA polymerase delta strand displacement activity by an abasic site can be rescued by the concerted action of DNA polymerase beta and Flap endonuclease 1. Maga G 2009 The Journal of biological chemistry
Design, synthesis, and structure-activity relationships of 1,3-dihydrobenzimidazol-2-one analogues as anti-HIV agents. Maga G 2009 Bioorganic & medicinal chemistry
Mutational analysis of the HIV-1 auxiliary protein Vif identifies independent domains important for the physical and functional interaction with HIV-1 reverse transcriptase. Maga G 2009 Nucleic acids research
Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus. Maga G 2009 Journal of medicinal chemistry
Specific targeting of highly conserved residues in the HIV-1 reverse transcriptase primer grip region. 2. Stereoselective interaction to overcome the effects of drug resistant mutations. Maga G 2009 Journal of medicinal chemistry
Non-nucleoside HIV-1 reverse transcriptase inhibitors di-halo-indolyl aryl sulfones achieve tight binding to drug-resistant mutants by targeting the enzyme-substrate complex. Maga G 2009 Antiviral research
Replication protein A and proliferating cell nuclear antigen coordinate DNA polymerase selection in 8-oxo-guanine repair. Maga G 2008 Proceedings of the National Academy of Sciences of the United States of America
Novel N1-substituted 1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside reverse transcriptase inhibitors. Maga G 2008 Bioorganic & medicinal chemistry
Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the "primer grip" region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants. Maga G 2008 Biochemical pharmacology
Substrate-induced stable enzyme-inhibitor complex formation allows tight binding of novel 2-aminopyrimidin-4(3H)-ones to drug-resistant HIV-1 reverse transcriptase mutants. Maga G 2008 ChemMedChem
A multidisciplinary approach for the identification of novel HIV-1 non-nucleoside reverse transcriptase inhibitors: S-DABOCs and DAVPs. Maga G 2008 ChemMedChem
AKAP149 binds to HIV-1 reverse transcriptase and is involved in the reverse transcription. Maga G 2008 Journal of molecular biology
The balance between the rates of incorporation and pyrophosphorolytic removal influences the HIV-1 reverse transcriptase bypass of an abasic site with deoxy-, dideoxy-, and ribonucleotides. Maga G 2008 Proteins
Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains. Maga G 2007 Bioorganic & medicinal chemistry letters
Replication of 2-hydroxyadenine-containing DNA and recognition by human MutSalpha. Maga G 2007 DNA repair
Error-free bypass of 2-hydroxyadenine by human DNA polymerase lambda with Proliferating Cell Nuclear Antigen and Replication Protein A in different sequence contexts. Maga G 2007 Nucleic acids research
Discovery of non-nucleoside inhibitors of HIV-1 reverse transcriptase competing with the nucleotide substrate. Maga G 2007 Angewandte Chemie (International ed. in English)
Expanding the repertoire of DNA polymerase substrates: template-instructed incorporation of non-nucleoside triphosphate analogues by DNA polymerases beta and lambda. Maga G 2007 Nucleic acids research
Human base excision repair complex is physically associated to DNA replication and cell cycle regulatory proteins. Maga G 2007 Nucleic acids research
Investigation of novel lipid-functionalized PNA monomers as potential HIV-1 non-nucleoside reverse transcriptase and/or integrase inhibitors. Maga G 2007 Nucleosides, nucleotides & nucleic acids
Indolyl aryl sulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: role of two halogen atoms at the indole ring in developing new analogues with improved antiviral activity. Maga G 2007 Journal of medicinal chemistry
NNRTI-selected mutations at codon 190 of human immunodeficiency virus type 1 reverse transcriptase decrease susceptibility to stavudine and zidovudine. Maga G 2007 Antiviral research
N2-benzyloxycarbonylguan-9-yl acetic acid derivatives as HIV-1 reverse transcriptase non-nucleoside inhibitors with decreased loss of potency against common drug-resistance mutations. Maga G 2007 ChemMedChem
Slow-, tight-binding HIV-1 reverse transcriptase non-nucleoside inhibitors highly active against drug-resistant mutants. Maga G 2007 ChemMedChem
Design, synthesis, biological evaluation, and molecular modeling studies of TIBO-like cyclic sulfones as non-nucleoside HIV-1 reverse transcriptase inhibitors. Maga G 2006 ChemMedChem
Human replication protein A can suppress the intrinsic in vitro mutator phenotype of human DNA polymerase lambda. Maga G 2006 Nucleic acids research
Human terminal deoxynucleotidyl transferases as novel targets for anticancer chemotherapy. Maga G 2006 Current medicinal chemistry
Arylthiopyrrole (AThP) derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis, structure-activity relationships, and docking studies (part 2). Maga G 2006 ChemMedChem
Arylthiopyrrole (AThP) derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis, structure-activity relationships, and docking studies (part 1). Maga G 2006 ChemMedChem
Indolyl aryl sulphones as HIV-1 non-nucleoside reverse transcriptase inhibitors: synthesis, biological evaluation and binding mode studies of new derivatives at indole-2-carboxamide. Maga G 2006 Antiviral chemistry & chemotherapy
DNA elongation by the human DNA polymerase lambda polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A. Maga G 2005 The Journal of biological chemistry
Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity. Maga G 2005 Journal of medicinal chemistry
Incorporation of non-nucleoside triphosphate analogues opposite to an abasic site by human DNA polymerases beta and lambda. Maga G 2005 Nucleic acids research
5-Alkyl-2-alkylamino-6-(2,6-difluorophenylalkyl)-3,4-dihydropyrimidin-4(3H)-ones, a new series of potent, broad-spectrum non-nucleoside reverse transcriptase inhibitors belonging to the DABO family. Maga G 2005 Bioorganic & medicinal chemistry
Drug resistance mutations in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase differentially affect the phosphorolysis-dependent primer unblocking activity in the presence of stavudine and zidovudine and its inhibition by efavirenz. Maga G 2005 Antimicrobial agents and chemotherapy
Novel 1-[2-(diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. A structure-activity relationship investigation. Maga G 2005 Journal of medicinal chemistry
8-oxoguanine incorporation into DNA repeats in vitro and mismatch recognition by MutSalpha. Maga G 2005 Nucleic acids research
Diketo hexenoic acid derivatives are novel selective non-nucleoside inhibitors of mammalian terminal deoxynucleotidyl transferases, with potent cytotoxic effect against leukemic cells. Maga G 2005 Molecular pharmacology
The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins. Maga G 2005 Molecular and cellular biology
Vif is an auxiliary factor of the HIV-1 reverse transcriptase and facilitates abasic site bypass. Maga G 2004 The Biochemical journal
Gln145Met/Leu changes in human immunodeficiency virus type 1 reverse transcriptase confer resistance to nucleoside and nonnucleoside analogs and impair virus replication. Maga G 2004 Antimicrobial agents and chemotherapy
HIV-1 reverse transcriptase inhibitors: current issues and future perspectives. Maga G 2004 Current drug metabolism
Effects of drug resistance mutations L100I and V106A on the binding of pyrrolobenzoxazepinone nonnucleoside inhibitors to the human immunodeficiency virus type 1 reverse transcriptase catalytic complex. Maga G 2004 Antimicrobial agents and chemotherapy
De novo DNA synthesis by human DNA polymerase lambda, DNA polymerase mu and terminal deoxyribonucleotidyl transferase. Maga G 2004 Journal of molecular biology
Human DNA polymerases lambda and beta show different efficiencies of translesion DNA synthesis past abasic sites and alternative mechanisms for frameshift generation. Maga G 2004 Biochemistry
The human DNA polymerase lambda interacts with PCNA through a domain important for DNA primer binding and the interaction is inhibited by p21/WAF1/CIP1. Maga G 2004 FASEB J
Human DNA polymerase lambda possesses terminal deoxyribonucleotidyl transferase activity and can elongate RNA primers: implications for novel functions. Maga G 2003 Journal of molecular biology
Proliferating cell nuclear antigen (PCNA): a dancer with many partners. Maga G 2003 Journal of cell science
Nevirapine resistance mutation at codon 181 of the HIV-1 reverse transcriptase confers stavudine resistance by increasing nucleotide substrate discrimination and phosphorolytic activity. Maga G 2003 The Journal of biological chemistry
Human proliferating cell nuclear antigen, poly(ADP-ribose) polymerase-1, and p21waf1/cip1. A dynamic exchange of partners. Maga G 2003 The Journal of biological chemistry
Detection of a new HIV-1 reverse transcriptase mutation (Q145M) conferring resistance to nucleoside and non-nucleoside inhibitors in a patient failing highly active antiretroviral therapy. Maga G 2003 AIDS (London, England)
Mutagenesis of human DNA polymerase lambda: essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities. Maga G 2003 Nucleic acids research
Human DNA polymerase lambda diverged in evolution from DNA polymerase beta toward specific Mn(++) dependence: a kinetic and thermodynamic study. Maga G 2003 Biochemistry
DNA polymerase lambda from calf thymus preferentially replicates damaged DNA. Maga G 2002 The Journal of biological chemistry
DNA polymerase theta purified from human cells is a high-fidelity enzyme. Maga G 2002 Journal of molecular biology
Cell cycle-dependent dynamic association of cyclin/Cdk complexes with human DNA replication proteins. Maga G 2002 The EMBO journal
Non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors: past, present, and future perspectives. Maga G 2002 Current pharmaceutical design
Combinations against combinations: associations of anti-HIV 1 reverse transcriptase drugs challenged by constellations of drug resistance mutations. Maga G 2002 Current drug metabolism
Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis. Maga G 2002 The Journal of biological chemistry
Reconstitution of the base excision repair pathway for 7,8-dihydro-8-oxoguanine with purified human proteins. Maga G 2002 Nucleic acids research
Eukaryotic DNA polymerases. Maga G 2002 Annual review of biochemistry
Replication protein A as a "fidelity clamp" for DNA polymerase alpha. Maga G 2001 The Journal of biological chemistry
Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent. Maga G 2001 Journal of medicinal chemistry
Potentiation of inhibition of wild-type and mutant human immunodeficiency virus type 1 reverse transcriptases by combinations of nonnucleoside inhibitors and d- and L-(beta)-dideoxynucleoside triphosphate analogs. Maga G 2001 Antimicrobial agents and chemotherapy
HIV-1 reverse transcriptase and integrase enzymes physically interact and inhibit each other. Maga G 2001 FEBS letters
The stereoselective targeting of a specific enzyme-substrate complex is the molecular mechanism for the synergic inhibition of HIV-1 reverse transcriptase by (R)-(-)-PPO464: a novel generation of nonnucleoside inhibitors. Maga G 2001 The Journal of biological chemistry
Okazaki fragment processing: modulation of the strand displacement activity of DNA polymerase delta by the concerted action of replication protein A, proliferating cell nuclear antigen, and flap endonuclease-1. Maga G 2001 Proceedings of the National Academy of Sciences of the United States of America
Non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis and biological evaluation of novel quinoxalinylethylpyridylthioureas as potent antiviral agents. Maga G 2000 Antiviral chemistry & chemotherapy
Selective interaction of the human immunodeficiency virus type 1 reverse transcriptase nonnucleoside inhibitor efavirenz and its thio-substituted analog with different enzyme-substrate complexes. Maga G 2000 Antimicrobial agents and chemotherapy
DNA polymerase switching: I. Replication factor C displaces DNA polymerase alpha prior to PCNA loading. Maga G 2000 Journal of molecular biology
Probing interactions between HIV-1 reverse transcriptase and its DNA substrate with backbone-modified nucleotides. Maga G 1999 Chemistry & biology
Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase: role of the 3'-hydroxyl group of the L-(beta)-ribose in chiral discrimination between D- and L-enantiomers of deoxy- and dideoxy-nucleoside triphosphate analogs. Maga G 1999 Nucleic acids research
Pyrrolobenzoxazepinone derivatives as non-nucleoside HIV-1 RT inhibitors: further structure-activity relationship studies and identification of more potent broad-spectrum HIV-1 RT inhibitors with antiviral activity. Maga G 1999 Journal of medicinal chemistry
Dual mode of interaction of DNA polymerase epsilon with proliferating cell nuclear antigen in primer binding and DNA synthesis. Maga G 1999 Journal of molecular biology
Molecular basis for the antiviral and anticancer activities of unnatural L-beta-nucleosides. Maga G 1998 Expert opinion on investigational drugs
The solution structure of functionally active human proliferating cell nuclear antigen determined by small-angle neutron scattering. Maga G 1998 Journal of molecular biology
Mutant DNA polymerase delta from thermosensitive Schizosaccharomyces pombe strains display reduced stimulation by proliferating cell nuclear antigen. Maga G 1998 Biochem J
Resistance to nevirapine of HIV-1 reverse transcriptase mutants: loss of stabilizing interactions and thermodynamic or steric barriers are induced by different single amino acid substitutions. Maga G 1997 Journal of molecular biology
DNA replication machinery: functional characterization of a complex containing DNA polymerase alpha, DNA polymerase delta, and replication factor C suggests an asymmetric DNA polymerase dimer. Maga G 1996 Biochemistry
DNA polymerase epsilon interacts with proliferating cell nuclear antigen in primer recognition and elongation. Maga G 1995 Biochemistry
Stereospecificity of human DNA polymerases alpha, beta, gamma, delta and epsilon, HIV-reverse transcriptase, HSV-1 DNA polymerase, calf thymus terminal transferase and Escherichia coli DNA polymerase I in recognizing D- and L-thymidine 5'-triphosphate as substrate. Maga G 1995 Nucleic acids research
Lack of stereospecificity of some cellular and viral enzymes involved in the synthesis of deoxyribonucleotides and DNA: molecular basis for the antiviral activity of unnatural L-beta-nucleosides. Maga G 1995 Biochimie
DNA polymerase beta bypasses in vitro a single d(GpG)-cisplatin adduct placed on codon 13 of the HRAS gene. Maga G 1995 Proceedings of the National Academy of Sciences of the United States of America
Aphidicolin inhibits in vitro the activity of pseudorabies virus (PRV) DNA polymerase and in vivo the viral proliferation. Maga G 1994 In Vivo
Effect of divalent and monovalent cations on calf thymus PCNA-independent DNA polymerase delta and its 3'----5' exonuclease. Maga G 1990 FEBS letters
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