Maga G

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Title	Authors	Year	Journal
Structure-based pharmacophore identification of new chemical scaffolds as non-nucleoside reverse transcriptase inhibitors.	Maga G		Journal of chemical information and modeling
Structural determinants of HIV-1 reverse transcriptase stereoselectivity towards (beta)-L-deoxy- and dideoxy-pyrimidine nucleoside triphosphates: molecular basis for the combination of L-dideoxynucleoside analogs with non-nucleoside inhibitors in anti HIV chemotherapy.	Maga G		Nucleosides & nucleotides
DNA polymerase δ-interacting protein 2 is a processivity factor for DNA polymerase λ during 8-oxo-7,8-dihydroguanine bypass.	Maga G	2013	Proceedings of the National Academy of Sciences of the United States of America
Silencing of human DNA polymerase λ causes replication stress and is synthetically lethal with an impaired S phase checkpoint.	Maga G	2012	Nucleic acids research
New Nitrogen Containing Substituents at the Indole-2-carboxamide Yield High Potent and Broad Spectrum Indolylarylsulfone HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors.	Maga G	2012	Journal of medicinal chemistry
Human DNA polymerase β, but not λ, can bypass a 2-deoxyribonolactone lesion together with proliferating cell nuclear antigen.	Maga G	2012	ACS chemical biology
2-(Alkyl/Aryl)Amino-6-Benzylpyrimidin-4(3H)-ones as Inhibitors of Wild-Type and Mutant HIV-1: Enantioselectivity Studies.	Maga G	2012	Journal of medicinal chemistry
Synthesis, Biological Activity, and ADME Properties of Novel S-DABOs/N-DABOs as HIV Reverse Transcriptase Inhibitors.	Maga G	2012	ChemMedChem
Mechanism of interaction of novel indolylarylsulfone derivatives with K103N and Y181I mutant HIV-1 reverse transcriptase in complex with its substrates.	Maga G	2011	Antiviral chemistry & chemotherapy
Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants.	Maga G	2011	Bioorganic & medicinal chemistry letters
Diarylpyrimidine-dihydrobenzyloxopyrimidine hybrids: new, wide-spectrum anti-HIV-1 agents active at (sub)-nanomolar level.	Maga G	2011	Journal of medicinal chemistry
Indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: new cyclic substituents at indole-2-carboxamide.	Maga G	2011	Journal of medicinal chemistry
DNA replication and repair bypass machines.	Maga G	2011	Current opinion in chemical biology
Oxidative DNA damage bypass in Arabidopsis thaliana requires DNA polymerase λ and proliferating cell nuclear antigen 2.	Maga G	2011	The Plant cell
A new proofreading mechanism for lesion bypass by DNA polymerase-λ	Maga G	2011	EMBO reports
Novel 1,3-dihydro-benzimidazol-2-ones and their analogues as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.	Maga G	2010	Bioorganic & medicinal chemistry
Slow binding-tight binding interaction between benzimidazol-2-one inhibitors and HIV-1 reverse transcriptase containing the lysine 103 to asparagine mutation.	Maga G	2010	Antiviral research
DNA polymerases beta and lambda bypass thymine glycol in gapped DNA structures.	Maga G	2010	Biochemistry
Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action.	Maga G	2010	Angew Chem Int Ed Engl
HIV-1 RT Inhibitors with a Novel Mechanism of Action: NNRTIs that Compete with the Nucleotide Substrate.	Maga G	2010	Viruses
Mutational analysis of the HIV-1 auxiliary protein Vif identifies independent domains important for the physical and functional interaction with HIV-1 reverse transcriptase.	Maga G	2009	Nucleic acids research
Specific targeting of highly conserved residues in the HIV-1 reverse transcriptase primer grip region. 2. Stereoselective interaction to overcome the effects of drug resistant mutations.	Maga G	2009	Journal of medicinal chemistry
The resveratrol analogue 4,4'-dihydroxy-trans-stilbene inhibits cell proliferation with higher efficiency but different mechanism from resveratrol.	Maga G	2009	The international journal of biochemistry & cell biology
Non-nucleoside HIV-1 reverse transcriptase inhibitors di-halo-indolyl aryl sulfones achieve tight binding to drug-resistant mutants by targeting the enzyme-substrate complex.	Maga G	2009	Antiviral research
The block of DNA polymerase delta strand displacement activity by an abasic site can be rescued by the concerted action of DNA polymerase beta and Flap endonuclease 1.	Maga G	2009	The Journal of biological chemistry
Discovery of chiral cyclopropyl dihydro-alkylthio-benzyl-oxopyrimidine (S-DABO) derivatives as potent HIV-1 reverse transcriptase inhibitors with high activity against clinically relevant mutants.	Maga G	2009	Journal of medicinal chemistry
Design, synthesis, and structure-activity relationships of 1,3-dihydrobenzimidazol-2-one analogues as anti-HIV agents.	Maga G	2009	Bioorganic & medicinal chemistry
Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.	Maga G	2009	Journal of medicinal chemistry
AKAP149 binds to HIV-1 reverse transcriptase and is involved in the reverse transcription.	Maga G	2008	Journal of molecular biology
Replication protein A and proliferating cell nuclear antigen coordinate DNA polymerase selection in 8-oxo-guanine repair.	Maga G	2008	Proceedings of the National Academy of Sciences of the United States of America
Novel N1-substituted 1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside reverse transcriptase inhibitors.	Maga G	2008	Bioorganic & medicinal chemistry
Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the "primer grip" region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants.	Maga G	2008	Biochemical pharmacology
Substrate-induced stable enzyme-inhibitor complex formation allows tight binding of novel 2-aminopyrimidin-4(3H)-ones to drug-resistant HIV-1 reverse transcriptase mutants.	Maga G	2008	ChemMedChem
A multidisciplinary approach for the identification of novel HIV-1 non-nucleoside reverse transcriptase inhibitors: S-DABOCs and DAVPs.	Maga G	2008	ChemMedChem
The balance between the rates of incorporation and pyrophosphorolytic removal influences the HIV-1 reverse transcriptase bypass of an abasic site with deoxy-, dideoxy-, and ribonucleotides.	Maga G	2008	Proteins
Human base excision repair complex is physically associated to DNA replication and cell cycle regulatory proteins.	Maga G	2007	Nucleic acids research
Replication of 2-hydroxyadenine-containing DNA and recognition by human MutSalpha.	Maga G	2007	DNA repair
Error-free bypass of 2-hydroxyadenine by human DNA polymerase lambda with Proliferating Cell Nuclear Antigen and Replication Protein A in different sequence contexts.	Maga G	2007	Nucleic acids research
Expanding the repertoire of DNA polymerase substrates: template-instructed incorporation of non-nucleoside triphosphate analogues by DNA polymerases beta and lambda.	Maga G	2007	Nucleic acids research
Indolyl aryl sulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: role of two halogen atoms at the indole ring in developing new analogues with improved antiviral activity.	Maga G	2007	Journal of medicinal chemistry
NNRTI-selected mutations at codon 190 of human immunodeficiency virus type 1 reverse transcriptase decrease susceptibility to stavudine and zidovudine.	Maga G	2007	Antiviral research
N2-benzyloxycarbonylguan-9-yl acetic acid derivatives as HIV-1 reverse transcriptase non-nucleoside inhibitors with decreased loss of potency against common drug-resistance mutations.	Maga G	2007	ChemMedChem
Slow-, tight-binding HIV-1 reverse transcriptase non-nucleoside inhibitors highly active against drug-resistant mutants.	Maga G	2007	ChemMedChem
Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains.	Maga G	2007	Bioorganic & medicinal chemistry letters
Investigation of novel lipid-functionalized PNA monomers as potential HIV-1 non-nucleoside reverse transcriptase and/or integrase inhibitors.	Maga G	2007	Nucleosides, nucleotides & nucleic acids
Discovery of non-nucleoside inhibitors of HIV-1 reverse transcriptase competing with the nucleotide substrate.	Maga G	2007	Angewandte Chemie (International ed. in English)
Indolyl aryl sulphones as HIV-1 non-nucleoside reverse transcriptase inhibitors: synthesis, biological evaluation and binding mode studies of new derivatives at indole-2-carboxamide.	Maga G	2006	Antiviral chemistry & chemotherapy
Human replication protein A can suppress the intrinsic in vitro mutator phenotype of human DNA polymerase lambda.	Maga G	2006	Nucleic acids research
Human terminal deoxynucleotidyl transferases as novel targets for anticancer chemotherapy.	Maga G	2006	Current medicinal chemistry
Arylthiopyrrole (AThP) derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis, structure-activity relationships, and docking studies (part 2).	Maga G	2006	ChemMedChem
Arylthiopyrrole (AThP) derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis, structure-activity relationships, and docking studies (part 1).	Maga G	2006	ChemMedChem
Design, synthesis, biological evaluation, and molecular modeling studies of TIBO-like cyclic sulfones as non-nucleoside HIV-1 reverse transcriptase inhibitors.	Maga G	2006	ChemMedChem
Diketo hexenoic acid derivatives are novel selective non-nucleoside inhibitors of mammalian terminal deoxynucleotidyl transferases, with potent cytotoxic effect against leukemic cells.	Maga G	2005	Molecular pharmacology
8-oxoguanine incorporation into DNA repeats in vitro and mismatch recognition by MutSalpha.	Maga G	2005	Nucleic acids research
The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins.	Maga G	2005	Molecular and cellular biology
Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity.	Maga G	2005	Journal of medicinal chemistry
Incorporation of non-nucleoside triphosphate analogues opposite to an abasic site by human DNA polymerases beta and lambda.	Maga G	2005	Nucleic acids research
Novel 1-[2-(diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. A structure-activity relationship investigation.	Maga G	2005	Journal of medicinal chemistry
5-Alkyl-2-alkylamino-6-(2,6-difluorophenylalkyl)-3,4-dihydropyrimidin-4(3H)-ones, a new series of potent, broad-spectrum non-nucleoside reverse transcriptase inhibitors belonging to the DABO family.	Maga G	2005	Bioorganic & medicinal chemistry
Drug resistance mutations in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase differentially affect the phosphorolysis-dependent primer unblocking activity in the presence of stavudine and zidovudine and its inhibition by efavirenz.	Maga G	2005	Antimicrobial agents and chemotherapy
DNA elongation by the human DNA polymerase lambda polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A.	Maga G	2005	The Journal of biological chemistry
Vif is an auxiliary factor of the HIV-1 reverse transcriptase and facilitates abasic site bypass.	Maga G	2004	The Biochemical journal
Gln145Met/Leu changes in human immunodeficiency virus type 1 reverse transcriptase confer resistance to nucleoside and nonnucleoside analogs and impair virus replication.	Maga G	2004	Antimicrobial agents and chemotherapy
De novo DNA synthesis by human DNA polymerase lambda, DNA polymerase mu and terminal deoxyribonucleotidyl transferase.	Maga G	2004	Journal of molecular biology
The human DNA polymerase lambda interacts with PCNA through a domain important for DNA primer binding and the interaction is inhibited by p21/WAF1/CIP1.	Maga G	2004	FASEB J
Human DNA polymerases lambda and beta show different efficiencies of translesion DNA synthesis past abasic sites and alternative mechanisms for frameshift generation.	Maga G	2004	Biochemistry
Effects of drug resistance mutations L100I and V106A on the binding of pyrrolobenzoxazepinone nonnucleoside inhibitors to the human immunodeficiency virus type 1 reverse transcriptase catalytic complex.	Maga G	2004	Antimicrobial agents and chemotherapy
HIV-1 reverse transcriptase inhibitors: current issues and future perspectives.	Maga G	2004	Current drug metabolism
Proliferating cell nuclear antigen (PCNA): a dancer with many partners.	Maga G	2003	Journal of cell science
Nevirapine resistance mutation at codon 181 of the HIV-1 reverse transcriptase confers stavudine resistance by increasing nucleotide substrate discrimination and phosphorolytic activity.	Maga G	2003	The Journal of biological chemistry
Human DNA polymerase lambda possesses terminal deoxyribonucleotidyl transferase activity and can elongate RNA primers: implications for novel functions.	Maga G	2003	Journal of molecular biology
Human proliferating cell nuclear antigen, poly(ADP-ribose) polymerase-1, and p21waf1/cip1. A dynamic exchange of partners.	Maga G	2003	The Journal of biological chemistry
Detection of a new HIV-1 reverse transcriptase mutation (Q145M) conferring resistance to nucleoside and non-nucleoside inhibitors in a patient failing highly active antiretroviral therapy.	Maga G	2003	AIDS (London, England)
Human DNA polymerase lambda diverged in evolution from DNA polymerase beta toward specific Mn(++) dependence: a kinetic and thermodynamic study.	Maga G	2003	Biochemistry
Mutagenesis of human DNA polymerase lambda: essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities.	Maga G	2003	Nucleic acids research
DNA polymerase lambda from calf thymus preferentially replicates damaged DNA.	Maga G	2002	The Journal of biological chemistry
Eukaryotic DNA polymerases.	Maga G	2002	Annual review of biochemistry
DNA polymerase theta purified from human cells is a high-fidelity enzyme.	Maga G	2002	Journal of molecular biology
Non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors: past, present, and future perspectives.	Maga G	2002	Current pharmaceutical design
Cell cycle-dependent dynamic association of cyclin/Cdk complexes with human DNA replication proteins.	Maga G	2002	The EMBO journal
Reconstitution of the base excision repair pathway for 7,8-dihydro-8-oxoguanine with purified human proteins.	Maga G	2002	Nucleic acids research
Combinations against combinations: associations of anti-HIV 1 reverse transcriptase drugs challenged by constellations of drug resistance mutations.	Maga G	2002	Current drug metabolism
Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis.	Maga G	2002	The Journal of biological chemistry
Potentiation of inhibition of wild-type and mutant human immunodeficiency virus type 1 reverse transcriptases by combinations of nonnucleoside inhibitors and d- and L-(beta)-dideoxynucleoside triphosphate analogs.	Maga G	2001	Antimicrobial agents and chemotherapy
HIV-1 reverse transcriptase and integrase enzymes physically interact and inhibit each other.	Maga G	2001	FEBS letters
The stereoselective targeting of a specific enzyme-substrate complex is the molecular mechanism for the synergic inhibition of HIV-1 reverse transcriptase by (R)-(-)-PPO464: a novel generation of nonnucleoside inhibitors.	Maga G	2001	The Journal of biological chemistry
Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent.	Maga G	2001	Journal of medicinal chemistry
Okazaki fragment processing: modulation of the strand displacement activity of DNA polymerase delta by the concerted action of replication protein A, proliferating cell nuclear antigen, and flap endonuclease-1.	Maga G	2001	Proceedings of the National Academy of Sciences of the United States of America
Replication protein A as a "fidelity clamp" for DNA polymerase alpha.	Maga G	2001	The Journal of biological chemistry
Selective interaction of the human immunodeficiency virus type 1 reverse transcriptase nonnucleoside inhibitor efavirenz and its thio-substituted analog with different enzyme-substrate complexes.	Maga G	2000	Antimicrobial agents and chemotherapy
DNA polymerase switching: I. Replication factor C displaces DNA polymerase alpha prior to PCNA loading.	Maga G	2000	Journal of molecular biology
Non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis and biological evaluation of novel quinoxalinylethylpyridylthioureas as potent antiviral agents.	Maga G	2000	Antiviral chemistry & chemotherapy
Probing interactions between HIV-1 reverse transcriptase and its DNA substrate with backbone-modified nucleotides.	Maga G	1999	Chemistry & biology
Pyrrolobenzoxazepinone derivatives as non-nucleoside HIV-1 RT inhibitors: further structure-activity relationship studies and identification of more potent broad-spectrum HIV-1 RT inhibitors with antiviral activity.	Maga G	1999	Journal of medicinal chemistry
Dual mode of interaction of DNA polymerase epsilon with proliferating cell nuclear antigen in primer binding and DNA synthesis.	Maga G	1999	Journal of molecular biology
Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase: role of the 3'-hydroxyl group of the L-(beta)-ribose in chiral discrimination between D- and L-enantiomers of deoxy- and dideoxy-nucleoside triphosphate analogs.	Maga G	1999	Nucleic acids research
The solution structure of functionally active human proliferating cell nuclear antigen determined by small-angle neutron scattering.	Maga G	1998	Journal of molecular biology
Molecular basis for the antiviral and anticancer activities of unnatural L-beta-nucleosides.	Maga G	1998	Expert opinion on investigational drugs
Mutant DNA polymerase delta from thermosensitive Schizosaccharomyces pombe strains display reduced stimulation by proliferating cell nuclear antigen.	Maga G	1998	Biochem J
Resistance to nevirapine of HIV-1 reverse transcriptase mutants: loss of stabilizing interactions and thermodynamic or steric barriers are induced by different single amino acid substitutions.	Maga G	1997	Journal of molecular biology
DNA replication machinery: functional characterization of a complex containing DNA polymerase alpha, DNA polymerase delta, and replication factor C suggests an asymmetric DNA polymerase dimer.	Maga G	1996	Biochemistry
DNA polymerase epsilon interacts with proliferating cell nuclear antigen in primer recognition and elongation.	Maga G	1995	Biochemistry
DNA polymerase beta bypasses in vitro a single d(GpG)-cisplatin adduct placed on codon 13 of the HRAS gene.	Maga G	1995	Proceedings of the National Academy of Sciences of the United States of America
Lack of stereospecificity of some cellular and viral enzymes involved in the synthesis of deoxyribonucleotides and DNA: molecular basis for the antiviral activity of unnatural L-beta-nucleosides.	Maga G	1995	Biochimie
Stereospecificity of human DNA polymerases alpha, beta, gamma, delta and epsilon, HIV-reverse transcriptase, HSV-1 DNA polymerase, calf thymus terminal transferase and Escherichia coli DNA polymerase I in recognizing D- and L-thymidine 5'-triphosphate as substrate.	Maga G	1995	Nucleic acids research
Aphidicolin inhibits in vitro the activity of pseudorabies virus (PRV) DNA polymerase and in vivo the viral proliferation.	Maga G	1994	In Vivo
Effect of divalent and monovalent cations on calf thymus PCNA-independent DNA polymerase delta and its 3'----5' exonuclease.	Maga G	1990	FEBS letters

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Maga G

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