Specific inhibition of human immunodeficiency virus type 1 reverse transcriptase mediated by soulattrolide, a coumarin isolated from the latex of calophyllum teysmannii.

Pengsuparp T, Serit M, Hughes SH, Soejarto DD, Pezzuto JM
Journal of natural products (1996), Volume 59, Page 839
PubMed entry Publisher's site

Abstract:

Soulattrolide (1), a coumarin isolated from Calophyllum teysmannii ...
Soulattrolide (1), a coumarin isolated from Calophyllum teysmannii latex, was found to be a potent inhibitor of HIV-1 reverse transcriptase (RT) with an IC50 of 0.34 microM. Inhibition was remarkably specific, with no appreciable activity being observed toward HIV-2 RT, AMV RT, RNA polymerase, or DNA polymerases alpha or beta.

Polymerases:

HIV RT

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