Dpb2 integrates the leading-strand DNA polymerase into the eukaryotic replisome.

Sengupta S, van Deursen F, De Piccoli G, Labib K
Current biology : CB (2013), Volume 23, Page 543
PubMed entry Publisher's site

Abstract:

The eukaryotic replisome is a critical determinant of genome integrity ...
The eukaryotic replisome is a critical determinant of genome integrity with a complex structure that remains poorly characterized. A central unresolved issue is how the Cdc45-MCM-GINS helicase is linked to DNA polymerase epsilon, which synthesizes the leading strand at replication forks and is an important focus of regulation.

Polymerases:

Sce Pol epsilon

Topics:

Accessory Proteins/Complexes

Status:

new topics/pols set partial results complete validated

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Version:20241007

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