Dpb2 integrates the leading-strand DNA polymerase into the eukaryotic replisome.

Abstract:

The eukaryotic replisome is a critical determinant of genome integrity with a complex structure that remains poorly characterized. A central unresolved issue is how the Cdc45-MCM-GINS helicase is linked to DNA polymerase epsilon, which synthesizes the leading strand at replication forks and is an important focus of regulation.

Polymerases:

Topics:

Accessory Proteins/Complexes

Status:

new topics/pols set partial results complete validated

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