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Hoffmann JS

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Publications:

Title Authors Year Journal
DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis. Hoffmann JS 2013 The Journal of cell biology
DNA polymerase κ-dependent DNA synthesis at stalled replication forks is important for CHK1 activation. Hoffmann JS 2013 The EMBO journal
DNA polymerase beta from Trypanosoma cruzi is involved in kinetoplast DNA replication and repair of oxidative lesions. Hoffmann JS 2012 Molecular and biochemical parasitology
The R438W polymorphism of human DNA polymerase lambda triggers cellular sensitivity to camptothecin by compromising the homologous recombination repair pathway. Hoffmann JS 2010 Carcinogenesis
A 'DNA replication' signature of progression and negative outcome in colorectal cancer. Hoffmann JS 2010 Oncogene
DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability. Hoffmann JS 2010 Proceedings of the National Academy of Sciences of the United States of America
Active site mutations in mammalian DNA polymerase delta alter accuracy and replication fork progression. Hoffmann JS 2010 The Journal of biological chemistry
Human DNA polymerase eta is required for common fragile site stability during unperturbed DNA replication. Hoffmann JS 2009 Molecular and cellular biology
Characterization of a natural mutator variant of human DNA polymerase lambda which promotes chromosomal instability by compromising NHEJ. Hoffmann JS 2009 PloS one
Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells. Hoffmann JS 2009 Molecular carcinogenesis
Regulation of DNA polymerase beta by the LMP1 oncoprotein of EBV through the nuclear factor-kappaB pathway. Hoffmann JS 2009 Cancer research
Biochemical studies with DNA polymerase beta and DNA polymerase beta-PAK of Trypanosoma cruzi suggest the involvement of these proteins in mitochondrial DNA maintenance. Hoffmann JS 2008 DNA repair
Characterization of promoter regulatory elements involved in downexpression of the DNA polymerase kappa in colorectal cancer. Hoffmann JS 2007 Oncogene
Upregulation of error-prone DNA polymerases beta and kappa slows down fork progression without activating the replication checkpoint. Hoffmann JS 2007 Cell Cycle
Analysis of DNA polymerase activity in vitro using non-radioactive primer extension assay in an automated DNA sequencer. Hoffmann JS 2007 Genet Mol Res
Involvement of DNA polymerase mu in the repair of a specific subset of DNA double-strand breaks in mammalian cells. Hoffmann JS 2007 Nucleic acids research
Enhanced expression and activity of DNA polymerase beta in chronic myelogenous leukemia. Hoffmann JS 2006 Anticancer Res
The DNA polymerase lambda is required for the repair of non-compatible DNA double strand breaks by NHEJ in mammalian cells. Hoffmann JS 2006 Nucleic acids research
Up-regulation of the error-prone DNA polymerase {kappa} promotes pleiotropic genetic alterations and tumorigenesis. Hoffmann JS 2005 Cancer research
Acylphloroglucinol derivatives from Mahurea palustris. Hoffmann JS 2005 Journal of natural products
Adaptation to DNA damage and stimulation of genetic instability: the double-edged sword mammalian DNA polymerase kappa. Hoffmann JS 2005 Biochimie
Modulation of cellular response to cisplatin by a novel inhibitor of DNA polymerase beta. Hoffmann JS 2005 Mol Pharmacol
DNA polymerase beta overexpression stimulates the Rad51-dependent homologous recombination in mammalian cells. Hoffmann JS 2004 Nucleic acids research
Evidence of finely tuned expression of DNA polymerase beta in vivo using transgenic mice. Hoffmann JS 2004 FEBS letters
DNA polymerase beta can incorporate ribonucleotides during DNA synthesis of undamaged and CPD-damaged DNA. Hoffmann JS 2003 Journal of molecular biology
Deregulated DNA polymerase beta induces chromosome instability and tumorigenesis. Hoffmann JS 2002 Cancer research
A role for DNA polymerase beta in mutagenic UV lesion bypass. Hoffmann JS 2002 The Journal of biological chemistry
Deregulated DNA polymerase beta strengthens ionizing radiation-induced nucleotidic and chromosomal instabilities. Hoffmann JS 2002 Oncogene
Involvement of DNA polymerase beta in DNA replication and mutagenic consequences. Hoffmann JS 2002 Journal of molecular biology
Localisation of human DNA polymerase kappa to replication foci. Hoffmann JS 2002 J Cell Sci
Enhanced expression and activity of DNA polymerase beta in human ovarian tumor cells: impact on sensitivity towards antitumor agents. Hoffmann JS 2001 Oncogene
DNA polymerase beta imbalance increases apoptosis and mutagenesis induced by oxidative stress. Hoffmann JS 2001 FEBS letters
Antitumor activity of 2',3'-dideoxycytidine nucleotide analog against tumors up-regulating DNA polymerase beta. Hoffmann JS 2001 Mol Pharmacol
Nucleotide excision repair DNA synthesis by excess DNA polymerase beta: a potential source of genetic instability in cancer cells. Hoffmann JS 2000 The FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Mutator phenotype of BCR--ABL transfected Ba/F3 cell lines and its association with enhanced expression of DNA polymerase beta. Hoffmann JS 1999 Oncogene
Overexpression of DNA polymerase beta: a genomic instability enhancer process. Hoffmann JS 1999 FASEB J
Overexpression of DNA polymerase beta in cell results in a mutator phenotype and a decreased sensitivity to anticancer drugs. Hoffmann JS 1998 Proceedings of the National Academy of Sciences of the United States of America
Overexpression of DNA polymerase beta sensitizes mammalian cells to 2',3'-deoxycytidine and 3'-azido-3'-deoxythymidine. Hoffmann JS 1997 Cancer research
In vitro bypass replication of the cisplatin-d(GpG) lesion by calf thymus DNA polymerase beta and human immunodeficiency virus type I reverse transcriptase is highly mutagenic. Hoffmann JS 1996 The Journal of biological chemistry
DNA polymerase beta bypasses in vitro a single d(GpG)-cisplatin adduct placed on codon 13 of the HRAS gene. Hoffmann JS 1995 Proceedings of the National Academy of Sciences of the United States of America
Mutagenicity and pausing of HIV reverse transcriptase during HIV plus-strand DNA synthesis. Hoffmann JS 1994 Nucleic acids research
Codons 12 and 13 of H-ras protooncogene interrupt the progression of DNA synthesis catalyzed by DNA polymerase alpha. Hoffmann JS 1993 Cancer research
In vitro DNA synthesis by DNA polymerase I and DNA polymerase alpha on single-stranded DNA containing either purine or pyrimidine monoadducts. Hoffmann JS 1992 Biochem Pharmacol
Interaction of cis-diamminedichloroplatinum (II) with single-stranded DNA in the presence or absence of Escherichia coli single-stranded binding protein. Hoffmann JS 1991 Biochemical pharmacology
Conversion of monofunctional DNA adducts of cis-diamminedichloroplatinum (II) to bifunctional lesions. Effect on the in vitro replication of single-stranded DNA by Escherichia coli DNA polymerase I and eukaryotic DNA polymerases alpha. Hoffmann JS 1989 The Journal of biological chemistry

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