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Li Y

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Publications:

Title Authors Year Journal
Unfavorable electrostatic and steric interactions in DNA polymerase β E295K mutant interfere with the enzyme's pathway. Li Y 2012 Journal of the American Chemical Society
Comparison of two POLQ mutants reveals that a polymerase-inactive POLQ retains significant function in tolerance to etoposide and γ-irradiation in mouse B cells. Li Y 2011 Genes to cells : devoted to molecular & cellular mechanisms
Modeling DNA polymerase μ motions: subtle transitions before chemistry. Li Y 2010 Biophysical journal
Incorporation of an inducible nucleotide analog into DNA by DNA polymerases. Li Y 2009 Bioorg Med Chem
Design of annulated pyrazoles as inhibitors of HIV-1 reverse transcriptase. Li Y 2008 J Med Chem
Discovery and optimization of pyridazinone non-nucleoside inhibitors of HIV-1 reverse transcriptase. Li Y 2008 Bioorganic & medicinal chemistry letters
Cloning, expression and characterization of human tissue-specific DNA polymerase lambda2. Li Y 2007 Sci China C Life Sci
Reverse transcriptase activity of hepatitis B virus (HBV) DNA polymerase within core capsid: interaction with deoxynucleoside triphosphates and anti-HBV L-deoxynucleoside analog triphosphates. Li Y 2004 Mol Pharmacol
Nucleotide insertion opposite a cis-syn thymine dimer by a replicative DNA polymerase from bacteriophage T7. Li Y 2004 Nature structural & molecular biology
Crystal structures of 2-acetylaminofluorene and 2-aminofluorene in complex with T7 DNA polymerase reveal mechanisms of mutagenesis. Li Y 2004 Proceedings of the National Academy of Sciences of the United States of America
Activity of the isolated HIV RNase H domain and specific inhibition by N-hydroxyimides. Li Y 2004 Biochem Biophys Res Commun
Stimulation of human DNA polymerase epsilon by MDM2. Li Y 2003 Nucleic acids research
[Osteogenic potential of fibroblasts with reconstituted telomerase activity]. Li Y 2002 Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
Crystal structures of a ddATP-, ddTTP-, ddCTP, and ddGTP- trapped ternary complex of Klentaq1: insights into nucleotide incorporation and selectivity. Li Y 2001 Protein science : a publication of the Protein Society
MDM2 interacts with the C-terminus of the catalytic subunit of DNA polymerase epsilon. Li Y 2000 Nucleic acids research
Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon. Li Y 2000 The Journal of biological chemistry
Structure-based design of Taq DNA polymerases with improved properties of dideoxynucleotide incorporation. Li Y 1999 Proceedings of the National Academy of Sciences of the United States of America
Crystal structures of the Klenow fragment of Thermus aquaticus DNA polymerase I complexed with deoxyribonucleoside triphosphates. Li Y 1998 Protein science : a publication of the Protein Society
Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation. Li Y 1998 The EMBO journal
Purification, cDNA cloning, and gene mapping of the small subunit of human DNA polymerase epsilon. Li Y 1997 The Journal of biological chemistry

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