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Clark AD

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Publications:

Title Authors Year Journal
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. Clark AD 2011 Journal of medicinal chemistry
Structural basis of HIV-1 resistance to AZT by excision. Clark AD 2010 Nature structural & molecular biology
Structural basis for the role of the K65R mutation in HIV-1 reverse transcriptase polymerization, excision antagonism, and tenofovir resistance. Clark AD 2009 The Journal of biological chemistry
Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site. Clark AD 2009 Structure (London, England : 1993)
High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations. Clark AD 2008 Proceedings of the National Academy of Sciences of the United States of America
Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design. Clark AD 2008 Nucleic acids research
Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097. Clark AD 2007 Journal of molecular biology
HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site. Clark AD 2006 ACS Chem Biol
In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine). Clark AD 2005 J Med Chem
Concentration and pH dependent aggregation of hydrophobic drug molecules and relevance to oral bioavailability. Clark AD 2005 J Med Chem
Crystal structures for HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: a new class of non-nucleoside inhibitors effective against a broad range of drug-resistant strains. Clark AD 2005 J Med Chem
Correlations between factors determining the pharmacokinetics and antiviral activity of HIV-1 non-nucleoside reverse transcriptase inhibitors of the diaryltriazine and diarylpyrimidine classes of compounds. Clark AD 2004 Drugs in R&D
Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir. Clark AD 2004 Nature structural & molecular biology
Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants. Clark AD 2004 J Med Chem
Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA. Clark AD 2002 The EMBO journal
The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance. Clark AD 2001 Journal of molecular biology
Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA. Clark AD 2001 The EMBO journal
Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids. Clark AD 1999 Proceedings of the National Academy of Sciences of the United States of America
Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance. Clark AD 1998 Journal of molecular biology
Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolution. Clark AD 1998 Journal of molecular biology
Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant. Clark AD 1996 Journal of molecular biology
Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms. Clark AD 1996 Structure (London, England : 1993)
Structure of HIV-1 reverse transcriptase in a complex with the non-nucleoside inhibitor alpha-APA R 95845 at 2.8 A resolution. Clark AD 1995 Structure (London, England : 1993)
Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA. Clark AD 1993 Proceedings of the National Academy of Sciences of the United States of America
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