Correlations between factors determining the pharmacokinetics and antiviral activity of HIV-1 non-nucleoside reverse transcriptase inhibitors of the diaryltriazine and diarylpyrimidine classes of compounds.

Lewi PJ, Arnold E, Andries K, Bohets H, Borghys H, Clark AD, Daeyaert FF, Das K, De Béthune MP, De Jonge MR, Heeres J, Koymans L, Leempoels J, Peeters J, Timmerman P, Van den Broeck W, Vanhoutte F, Van't Klooster G, Vinkers MH, Volovik Y, Janssen PA
Drugs in R&D (2004), Volume 5, Page 245
PubMed entry

Abstract:

To investigate the important factors that determine the ...
To investigate the important factors that determine the bioavailability and the antiviral activity of the diaryltriazine (DATA) and diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitors (NNRTIs) of HIV-1 in animal species and humans using cell-based assays, physicochemical and computed parameters.

Polymerases:

HIV RT

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