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Geacintov NE

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Publications:

Title Authors Year Journal
Preferred WMSA catalytic mechanism of the nucleotidyl transfer reaction in human DNA polymerase κ elucidates error-free bypass of a bulky DNA lesion. Geacintov NE 2012 Nucleic acids research
Human DNA polymerase λ catalyzes lesion bypass across benzo[a]pyrene-derived DNA adduct during base excision repair. Geacintov NE 2012 DNA repair
Mechanism of error-free and semitargeted mutagenic bypass of an aromatic amine lesion by Y-family polymerase Dpo4. Geacintov NE 2010 Nature structural & molecular biology
Visualizing sequence-governed nucleotide selectivities and mutagenic consequences through a replicative cycle: processing of a bulky carcinogen N2-dG lesion in a Y-family DNA polymerase. Geacintov NE 2009 Biochemistry
DNA polymerase zeta cooperates with polymerases kappa and iota in translesion DNA synthesis across pyrimidine photodimers in cells from XPV patients. Geacintov NE 2009 Proceedings of the National Academy of Sciences of the United States of America
Impact of conformational heterogeneity of OxoG lesions and their pairing partners on bypass fidelity by Y family polymerases. Geacintov NE 2009 Structure (London, England : 1993)
Lesion processing: high-fidelity versus lesion-bypass DNA polymerases. Geacintov NE 2008 Trends in biochemical sciences
The N-clasp of human DNA polymerase kappa promotes blockage or error-free bypass of adenine- or guanine-benzo[a]pyrenyl lesions. Geacintov NE 2008 Nucleic acids research
Nucleotide selectivity opposite a benzo[a]pyrene-derived N2-dG adduct in a Y-family DNA polymerase: a 5'-slippage mechanism. Geacintov NE 2008 Biochemistry
Reduced efficiency and increased mutagenicity of translesion DNA synthesis across a TT cyclobutane pyrimidine dimer, but not a TT 6-4 photoproduct, in human cells lacking DNA polymerase eta. Geacintov NE 2008 DNA repair
Following an environmental carcinogen N2-dG adduct through replication: elucidating blockage and bypass in a high-fidelity DNA polymerase. Geacintov NE 2007 Nucleic acids research
Increased flexibility enhances misincorporation: temperature effects on nucleotide incorporation opposite a bulky carcinogen-DNA adduct by a Y-family DNA polymerase. Geacintov NE 2007 The Journal of biological chemistry
Poleta, Polzeta and Rev1 together are required for G to T transversion mutations induced by the (+)- and (-)-trans-anti-BPDE-N2-dG DNA adducts in yeast cells. Geacintov NE 2006 Nucleic acids research
Stepwise translocation of Dpo4 polymerase during error-free bypass of an oxoG lesion. Geacintov NE 2006 PLoS Biol
Accommodation of a 1S-(-)-benzo[c]phenanthrenyl-N6-dA adduct in the Y-family Dpo4 DNA polymerase active site: structural insights through molecular dynamics simulations. Geacintov NE 2005 Chemical research in toxicology
Structure of a high fidelity DNA polymerase bound to a benzo[a]pyrene adduct that blocks replication. Geacintov NE 2005 The Journal of biological chemistry
The spacious active site of a Y-family DNA polymerase facilitates promiscuous nucleotide incorporation opposite a bulky carcinogen-DNA adduct: elucidating the structure-function relationship through experimental and computational approaches. Geacintov NE 2004 The Journal of biological chemistry
Quantitative analysis of translesion DNA synthesis across a benzo[a]pyrene-guanine adduct in mammalian cells: the role of DNA polymerase kappa. Geacintov NE 2004 The Journal of biological chemistry
Altering DNA polymerase incorporation fidelity by distorting the dNTP binding pocket with a bulky carcinogen-damaged template. Geacintov NE 2004 Biochemistry
Mutagenesis of benzo[a]pyrene diol epoxide in yeast: requirement for DNA polymerase zeta and involvement of DNA polymerase eta. Geacintov NE 2003 Biochemistry
Two-step error-prone bypass of the (+)- and (-)-trans-anti-BPDE-N2-dG adducts by human DNA polymerases eta and kappa. Geacintov NE 2002 Mutation research
Response of human REV1 to different DNA damage: preferential dCMP insertion opposite the lesion. Geacintov NE 2002 Nucleic acids research
trans-Lesion synthesis past bulky benzo[a]pyrene diol epoxide N2-dG and N6-dA lesions catalyzed by DNA bypass polymerases. Geacintov NE 2002 The Journal of biological chemistry
Lesion bypass activities of human DNA polymerase mu. Geacintov NE 2002 The Journal of biological chemistry
Translesion synthesis by human DNA polymerase kappa on a DNA template containing a single stereoisomer of dG-(+)- or dG-(-)-anti-N(2)-BPDE (7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene). Geacintov NE 2002 Biochemistry
Base sequence dependence of in vitro translesional DNA replication past a bulky lesion catalyzed by the exo- Klenow fragment of Pol I. Geacintov NE 2001 Biochemistry
Error-prone lesion bypass by human DNA polymerase eta. Geacintov NE 2000 Nucleic acids research
Error-free and error-prone lesion bypass by human DNA polymerase kappa in vitro. Geacintov NE 2000 Nucleic acids research
Primer length dependence of binding of DNA polymerase I Klenow fragment to template-primer complexes containing site-specific bulky lesions. Geacintov NE 1999 Biochemistry
Translesional synthesis on a DNA template containing a single stereoisomer of dG-(+)- or dG-(-)-anti-BPDE (7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene). Geacintov NE 1993 Biochemistry

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