Increased flexibility enhances misincorporation: temperature effects on nucleotide incorporation opposite a bulky carcinogen-DNA adduct by a Y-family DNA polymerase.

Abstract:

The Y-family DNA polymerase Dpo4, from the thermophilic crenarchaeon ...

Polymerases:

Topics:

Nucleotide Analogs / Template Lesions, Structure and Structure/Function, Fidelity, Nucleotide Incorporation

Status:

new topics/pols set partial results complete validated

Results:

Polymerase Reference Property Result Context
Dpo4 Increased flexibility enhances misincorporation: temperature effects on nucleotide incorporation opposite a bulky carcinogen-DNA adduct by a Y-family DNA polymerase. Template lesions Bypasses Reaction: Nucleotide incorporation; Substrate: dNTPs; DNA lesion: 8-oxo-dG

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