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Prasad R

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Publications:

Title Authors Year Journal
Mutagenesis dependent upon the combination of activation-induced deaminase expression and a double-strand break. Prasad R Molecular immunology
A review of recent experiments on step-to-step "hand-off" of the DNA intermediates in mammalian base excision repair pathways. Prasad R Molekuliarnaia biologiia
Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses. Prasad R 2013 DNA repair
Pol β associated complex and base excision repair factors in mouse fibroblasts. Prasad R 2012 Nucleic acids research
Evidence for Abasic Site Sugar Phosphate-Mediated Cytotoxicity in Alkylating Agent Treated Saccharomyces cerevisiae. Prasad R 2012 PloS one
Single-nucleotide base excision repair DNA polymerase activity in C. elegans in the absence of DNA polymerase {beta} Prasad R 2011 Nucleic acids research
Base excision repair and design of small molecule inhibitors of human DNA polymerase beta. Prasad R 2010 Cell Mol Life Sci
Substrate channeling in mammalian base excision repair pathways: passing the baton. Prasad R 2010 The Journal of biological chemistry
DNA polymerase beta-dependent long patch base excision repair in living cells. Prasad R 2010 DNA repair
Mutagenic conformation of 8-oxo-7,8-dihydro-2'-dGTP in the confines of a DNA polymerase active site. Prasad R 2010 Nature structural & molecular biology
Characterization of DNA polymerase beta splicing variants in gastric cancer: the most frequent exon 2-deleted isoform is a non-coding RNA. Prasad R 2009 Mutation research
Human DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro. Prasad R 2009 Nucleic acids research
Down-regulation of DNA polymerase beta accompanies somatic hypermutation in human BL2 cell lines. Prasad R 2007 DNA repair
Interplay between DNA polymerases beta and lambda in repair of oxidation DNA damage in chicken DT40 cells. Prasad R 2007 DNA repair
Different structural states in oligonucleosomes are required for early versus late steps of base excision repair. Prasad R 2007 Nucleic acids research
Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress. Prasad R 2007 The Journal of biological chemistry
HMGB1 is a cofactor in mammalian base excision repair. Prasad R 2007 Molecular cell
Coordination of steps in single-nucleotide base excision repair mediated by apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta. Prasad R 2007 The Journal of biological chemistry
Determination of lysine pK values using [5-13C]lysine: application to the lyase domain of DNA Pol beta. Prasad R 2006 Journal of the American Chemical Society
Activities and mechanism of DNA polymerase beta. Prasad R 2006 Methods in enzymology
Structure of DNA polymerase beta with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features. Prasad R 2006 Proceedings of the National Academy of Sciences of the United States of America
NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells. Prasad R 2006 DNA repair
Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage. Prasad R 2006 Molecular cell
The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta. Prasad R 2006 Nucleic acids research
DNA polymerase beta and flap endonuclease 1 enzymatic specificities sustain DNA synthesis for long patch base excision repair. Prasad R 2005 The Journal of biological chemistry
REV1 mediated mutagenesis in base excision repair deficient mouse fibroblast. Prasad R 2005 DNA repair
Human base excision repair enzymes apurinic/apyrimidinic endonuclease1 (APE1), DNA polymerase beta and poly(ADP-ribose) polymerase 1: interplay between strand-displacement DNA synthesis and proofreading exonuclease activity. Prasad R 2005 Nucleic acids research
DNA polymerase lambda mediates a back-up base excision repair activity in extracts of mouse embryonic fibroblasts. Prasad R 2005 The Journal of biological chemistry
Structural insight into the DNA polymerase beta deoxyribose phosphate lyase mechanism. Prasad R 2005 DNA repair
Identification of small molecule synthetic inhibitors of DNA polymerase beta by NMR chemical shift mapping. Prasad R 2004 The Journal of biological chemistry
High-level expression and purification of untagged and histidine-tagged HIV-1 reverse transcriptase. Prasad R 2004 Protein expression and purification
AP endonuclease-independent DNA base excision repair in human cells. Prasad R 2004 Molecular cell
AP endonuclease and poly(ADP-ribose) polymerase-1 interact with the same base excision repair intermediate. Prasad R 2004 DNA repair
The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity. Prasad R 2003 The Journal of biological chemistry
Localization of the deoxyribose phosphate lyase active site in human DNA polymerase iota by controlled proteolysis. Prasad R 2003 The Journal of biological chemistry
Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses. Prasad R 2003 The Journal of biological chemistry
Binary system for selective photoaffinity labeling of base excision repair DNA polymerases. Prasad R 2002 Nucleic acids research
Direct interaction between mammalian DNA polymerase beta and proliferating cell nuclear antigen. Prasad R 2002 The Journal of biological chemistry
A type IB topoisomerase with DNA repair activities. Prasad R 2001 Proceedings of the National Academy of Sciences of the United States of America
DNA polymerase beta -mediated long patch base excision repair. Poly(ADP-ribose)polymerase-1 stimulates strand displacement DNA synthesis. Prasad R 2001 The Journal of biological chemistry
Photoaffinity labeling of mouse fibroblast enzymes by a base excision repair intermediate. Evidence for the role of poly(ADP-ribose) polymerase-1 in DNA repair. Prasad R 2001 The Journal of biological chemistry
5'-Deoxyribose phosphate lyase activity of human DNA polymerase iota in vitro. Prasad R 2001 Science
DNA polymerase beta and mammalian base excision repair. Prasad R 2000 Cold Spring Harbor symposia on quantitative biology
Protection against methylation-induced cytotoxicity by DNA polymerase beta-dependent long patch base excision repair. Prasad R 2000 The Journal of biological chemistry
Vertical-scanning mutagenesis of a critical tryptophan in the "minor groove binding track" of HIV-1 reverse transcriptase. Major groove DNA adducts identify specific protein interactions in the minor groove. Prasad R 2000 The Journal of biological chemistry
Domain specific interaction in the XRCC1-DNA polymerase beta complex. Prasad R 2000 Nucleic acids research
Backbone dynamics and refined solution structure of the N-terminal domain of DNA polymerase beta. Correlation with DNA binding and dRP lyase activity. Prasad R 2000 Journal of molecular biology
Mapping of the 5'-2-deoxyribose-5-phosphate lyase active site in DNA polymerase beta by mass spectrometry. Prasad R 2000 The Journal of biological chemistry
FEN1 stimulation of DNA polymerase beta mediates an excision step in mammalian long patch base excision repair. Prasad R 2000 The Journal of biological chemistry
8-oxodGTP incorporation by DNA polymerase beta is modified by active-site residue Asn279. Prasad R 2000 Biochemistry
Role of DNA polymerase beta in the excision step of long patch mammalian base excision repair. Prasad R 1999 The Journal of biological chemistry
Mammalian abasic site base excision repair. Identification of the reaction sequence and rate-determining steps. Prasad R 1998 The Journal of biological chemistry
Human DNA polymerase beta deoxyribose phosphate lyase. Substrate specificity and catalytic mechanism. Prasad R 1998 The Journal of biological chemistry
Identification of 5'-deoxyribose phosphate lyase activity in human DNA polymerase gamma and its role in mitochondrial base excision repair in vitro. Prasad R 1998 Proceedings of the National Academy of Sciences of the United States of America
Subunits of human replication protein A are crosslinked by photoreactive primers synthesized by DNA polymerases. Prasad R 1998 Nucleic acids research
Vertical-scanning mutagenesis of a critical tryptophan in the minor groove binding track of HIV-1 reverse transcriptase. Molecular nature of polymerase-nucleic acid interactions. Prasad R 1998 The Journal of biological chemistry
Thermodynamics of human DNA ligase I trimerization and association with DNA polymerase beta. Prasad R 1998 The Journal of biological chemistry
Functional analysis of the amino-terminal 8-kDa domain of DNA polymerase beta as revealed by site-directed mutagenesis. DNA binding and 5'-deoxyribose phosphate lyase activities. Prasad R 1998 The Journal of biological chemistry
A minor groove binding track in reverse transcriptase. Prasad R 1997 Nat Struct Biol
Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism. Prasad R 1997 Biochemistry
Probing structure/function relationships of HIV-1 reverse transcriptase with styrene oxide N2-guanine adducts. Prasad R 1997 The Journal of biological chemistry
Enzyme-DNA interactions required for efficient nucleotide incorporation and discrimination in human DNA polymerase beta. Prasad R 1996 The Journal of biological chemistry
Role of the "helix clamp" in HIV-1 reverse transcriptase catalytic cycling as revealed by alanine-scanning mutagenesis. Prasad R 1996 The Journal of biological chemistry
DNA polymerases alpha and beta are required for DNA repair in an efficient nuclear extract from Xenopus oocytes. Prasad R 1996 The Journal of biological chemistry
Evidence for an imino intermediate in the DNA polymerase beta deoxyribose phosphate excision reaction. Prasad R 1996 The Journal of biological chemistry
Specific interaction of DNA polymerase beta and DNA ligase I in a multiprotein base excision repair complex from bovine testis. Prasad R 1996 The Journal of biological chemistry
dNTP binding to HIV-1 reverse transcriptase and mammalian DNA polymerase beta as revealed by affinity labeling with a photoreactive dNTP analog. Prasad R 1996 The Journal of biological chemistry
Requirement of mammalian DNA polymerase-beta in base-excision repair. Prasad R 1996 Nature
Three-dimensional solution structure of the N-terminal domain of DNA polymerase beta and mapping of the ssDNA interaction interface. Prasad R 1996 Biochemistry
Specific inhibition of DNA polymerase beta by its 14 kDa domain: role of single- and double-stranded DNA binding and 5'-phosphate recognition. Prasad R 1995 Nucleic acids research
DNA polymerase beta conducts the gap-filling step in uracil-initiated base excision repair in a bovine testis nuclear extract. Prasad R 1995 The Journal of biological chemistry
Studies of gapped DNA substrate binding by mammalian DNA polymerase beta. Dependence on 5'-phosphate group. Prasad R 1994 The Journal of biological chemistry
Assignments of 1H, 15N, and 13C resonances for the backbone and side chains of the N-terminal domain of DNA polymerase beta. Determination of the secondary structure and tertiary contacts. Prasad R 1994 Biochemistry
Yeast open reading frame YCR14C encodes a DNA beta-polymerase-like enzyme. Prasad R 1993 Nucleic acids research
Identification of residues in the single-stranded DNA-binding site of the 8-kDa domain of rat DNA polymerase beta by UV cross-linking. Prasad R 1993 The Journal of biological chemistry

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