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Prasad R

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Publications:

Title Authors Year Journal
A review of recent experiments on step-to-step "hand-off" of the DNA intermediates in mammalian base excision repair pathways. Prasad R Molekuliarnaia biologiia
Mutagenesis dependent upon the combination of activation-induced deaminase expression and a double-strand break. Prasad R Molecular immunology
Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses. Prasad R 2013 DNA repair
Pol β associated complex and base excision repair factors in mouse fibroblasts. Prasad R 2012 Nucleic acids research
Evidence for Abasic Site Sugar Phosphate-Mediated Cytotoxicity in Alkylating Agent Treated Saccharomyces cerevisiae. Prasad R 2012 PloS one
Single-nucleotide base excision repair DNA polymerase activity in C. elegans in the absence of DNA polymerase {beta} Prasad R 2011 Nucleic acids research
Base excision repair and design of small molecule inhibitors of human DNA polymerase beta. Prasad R 2010 Cell Mol Life Sci
DNA polymerase beta-dependent long patch base excision repair in living cells. Prasad R 2010 DNA repair
Mutagenic conformation of 8-oxo-7,8-dihydro-2'-dGTP in the confines of a DNA polymerase active site. Prasad R 2010 Nature structural & molecular biology
Substrate channeling in mammalian base excision repair pathways: passing the baton. Prasad R 2010 The Journal of biological chemistry
Characterization of DNA polymerase beta splicing variants in gastric cancer: the most frequent exon 2-deleted isoform is a non-coding RNA. Prasad R 2009 Mutation research
Human DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro. Prasad R 2009 Nucleic acids research
Interplay between DNA polymerases beta and lambda in repair of oxidation DNA damage in chicken DT40 cells. Prasad R 2007 DNA repair
Different structural states in oligonucleosomes are required for early versus late steps of base excision repair. Prasad R 2007 Nucleic acids research
Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress. Prasad R 2007 The Journal of biological chemistry
HMGB1 is a cofactor in mammalian base excision repair. Prasad R 2007 Molecular cell
Down-regulation of DNA polymerase beta accompanies somatic hypermutation in human BL2 cell lines. Prasad R 2007 DNA repair
Coordination of steps in single-nucleotide base excision repair mediated by apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta. Prasad R 2007 The Journal of biological chemistry
Structure of DNA polymerase beta with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features. Prasad R 2006 Proceedings of the National Academy of Sciences of the United States of America
The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta. Prasad R 2006 Nucleic acids research
Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage. Prasad R 2006 Molecular cell
NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells. Prasad R 2006 DNA repair
Determination of lysine pK values using [5-13C]lysine: application to the lyase domain of DNA Pol beta. Prasad R 2006 Journal of the American Chemical Society
Activities and mechanism of DNA polymerase beta. Prasad R 2006 Methods in enzymology
DNA polymerase beta and flap endonuclease 1 enzymatic specificities sustain DNA synthesis for long patch base excision repair. Prasad R 2005 The Journal of biological chemistry
REV1 mediated mutagenesis in base excision repair deficient mouse fibroblast. Prasad R 2005 DNA repair
Human base excision repair enzymes apurinic/apyrimidinic endonuclease1 (APE1), DNA polymerase beta and poly(ADP-ribose) polymerase 1: interplay between strand-displacement DNA synthesis and proofreading exonuclease activity. Prasad R 2005 Nucleic acids research
Structural insight into the DNA polymerase beta deoxyribose phosphate lyase mechanism. Prasad R 2005 DNA repair
DNA polymerase lambda mediates a back-up base excision repair activity in extracts of mouse embryonic fibroblasts. Prasad R 2005 The Journal of biological chemistry
AP endonuclease and poly(ADP-ribose) polymerase-1 interact with the same base excision repair intermediate. Prasad R 2004 DNA repair
AP endonuclease-independent DNA base excision repair in human cells. Prasad R 2004 Molecular cell
High-level expression and purification of untagged and histidine-tagged HIV-1 reverse transcriptase. Prasad R 2004 Protein expression and purification
Identification of small molecule synthetic inhibitors of DNA polymerase beta by NMR chemical shift mapping. Prasad R 2004 The Journal of biological chemistry
Localization of the deoxyribose phosphate lyase active site in human DNA polymerase iota by controlled proteolysis. Prasad R 2003 The Journal of biological chemistry
Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses. Prasad R 2003 The Journal of biological chemistry
The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity. Prasad R 2003 The Journal of biological chemistry
Direct interaction between mammalian DNA polymerase beta and proliferating cell nuclear antigen. Prasad R 2002 The Journal of biological chemistry
Binary system for selective photoaffinity labeling of base excision repair DNA polymerases. Prasad R 2002 Nucleic acids research
5'-Deoxyribose phosphate lyase activity of human DNA polymerase iota in vitro. Prasad R 2001 Science
DNA polymerase beta -mediated long patch base excision repair. Poly(ADP-ribose)polymerase-1 stimulates strand displacement DNA synthesis. Prasad R 2001 The Journal of biological chemistry
Photoaffinity labeling of mouse fibroblast enzymes by a base excision repair intermediate. Evidence for the role of poly(ADP-ribose) polymerase-1 in DNA repair. Prasad R 2001 The Journal of biological chemistry
A type IB topoisomerase with DNA repair activities. Prasad R 2001 Proceedings of the National Academy of Sciences of the United States of America
FEN1 stimulation of DNA polymerase beta mediates an excision step in mammalian long patch base excision repair. Prasad R 2000 The Journal of biological chemistry
DNA polymerase beta and mammalian base excision repair. Prasad R 2000 Cold Spring Harbor symposia on quantitative biology
Vertical-scanning mutagenesis of a critical tryptophan in the "minor groove binding track" of HIV-1 reverse transcriptase. Major groove DNA adducts identify specific protein interactions in the minor groove. Prasad R 2000 The Journal of biological chemistry
Domain specific interaction in the XRCC1-DNA polymerase beta complex. Prasad R 2000 Nucleic acids research
Protection against methylation-induced cytotoxicity by DNA polymerase beta-dependent long patch base excision repair. Prasad R 2000 The Journal of biological chemistry
Backbone dynamics and refined solution structure of the N-terminal domain of DNA polymerase beta. Correlation with DNA binding and dRP lyase activity. Prasad R 2000 Journal of molecular biology
8-oxodGTP incorporation by DNA polymerase beta is modified by active-site residue Asn279. Prasad R 2000 Biochemistry
Mapping of the 5'-2-deoxyribose-5-phosphate lyase active site in DNA polymerase beta by mass spectrometry. Prasad R 2000 The Journal of biological chemistry
Role of DNA polymerase beta in the excision step of long patch mammalian base excision repair. Prasad R 1999 The Journal of biological chemistry
Mammalian abasic site base excision repair. Identification of the reaction sequence and rate-determining steps. Prasad R 1998 The Journal of biological chemistry
Identification of 5'-deoxyribose phosphate lyase activity in human DNA polymerase gamma and its role in mitochondrial base excision repair in vitro. Prasad R 1998 Proceedings of the National Academy of Sciences of the United States of America
Thermodynamics of human DNA ligase I trimerization and association with DNA polymerase beta. Prasad R 1998 The Journal of biological chemistry
Subunits of human replication protein A are crosslinked by photoreactive primers synthesized by DNA polymerases. Prasad R 1998 Nucleic acids research
Human DNA polymerase beta deoxyribose phosphate lyase. Substrate specificity and catalytic mechanism. Prasad R 1998 The Journal of biological chemistry
Functional analysis of the amino-terminal 8-kDa domain of DNA polymerase beta as revealed by site-directed mutagenesis. DNA binding and 5'-deoxyribose phosphate lyase activities. Prasad R 1998 The Journal of biological chemistry
Vertical-scanning mutagenesis of a critical tryptophan in the minor groove binding track of HIV-1 reverse transcriptase. Molecular nature of polymerase-nucleic acid interactions. Prasad R 1998 The Journal of biological chemistry
Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism. Prasad R 1997 Biochemistry
A minor groove binding track in reverse transcriptase. Prasad R 1997 Nat Struct Biol
Probing structure/function relationships of HIV-1 reverse transcriptase with styrene oxide N2-guanine adducts. Prasad R 1997 The Journal of biological chemistry
Three-dimensional solution structure of the N-terminal domain of DNA polymerase beta and mapping of the ssDNA interaction interface. Prasad R 1996 Biochemistry
Requirement of mammalian DNA polymerase-beta in base-excision repair. Prasad R 1996 Nature
Enzyme-DNA interactions required for efficient nucleotide incorporation and discrimination in human DNA polymerase beta. Prasad R 1996 The Journal of biological chemistry
dNTP binding to HIV-1 reverse transcriptase and mammalian DNA polymerase beta as revealed by affinity labeling with a photoreactive dNTP analog. Prasad R 1996 The Journal of biological chemistry
DNA polymerases alpha and beta are required for DNA repair in an efficient nuclear extract from Xenopus oocytes. Prasad R 1996 The Journal of biological chemistry
Evidence for an imino intermediate in the DNA polymerase beta deoxyribose phosphate excision reaction. Prasad R 1996 The Journal of biological chemistry
Specific interaction of DNA polymerase beta and DNA ligase I in a multiprotein base excision repair complex from bovine testis. Prasad R 1996 The Journal of biological chemistry
Role of the "helix clamp" in HIV-1 reverse transcriptase catalytic cycling as revealed by alanine-scanning mutagenesis. Prasad R 1996 The Journal of biological chemistry
Specific inhibition of DNA polymerase beta by its 14 kDa domain: role of single- and double-stranded DNA binding and 5'-phosphate recognition. Prasad R 1995 Nucleic acids research
DNA polymerase beta conducts the gap-filling step in uracil-initiated base excision repair in a bovine testis nuclear extract. Prasad R 1995 The Journal of biological chemistry
Assignments of 1H, 15N, and 13C resonances for the backbone and side chains of the N-terminal domain of DNA polymerase beta. Determination of the secondary structure and tertiary contacts. Prasad R 1994 Biochemistry
Studies of gapped DNA substrate binding by mammalian DNA polymerase beta. Dependence on 5'-phosphate group. Prasad R 1994 The Journal of biological chemistry
Yeast open reading frame YCR14C encodes a DNA beta-polymerase-like enzyme. Prasad R 1993 Nucleic acids research
Identification of residues in the single-stranded DNA-binding site of the 8-kDa domain of rat DNA polymerase beta by UV cross-linking. Prasad R 1993 The Journal of biological chemistry
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