The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations.


Using a combination of traditional Medicinal Chemistry/SAR analysis, crystallography, and molecular modeling, we have designed and synthesized a series of novel, highly potent NNRTIs that possess broad antiviral activity against a number of key clinical mutations.



Structure and Structure/Function, Reverse Transcriptase


new topics/pols set partial results complete validated


Polymerase Reference Property Result Context
HIV RT Tucker TJ2008 Reverse Transcriptase Activity Yes

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