Discovery of 3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5 -chlorobenzonitrile (MK-4965): a potent, orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitor with improved potency against key mutant viruses.
Tucker TJ, Sisko JT, Tynebor RM, Williams TM, Felock PJ, Flynn JA, Lai MT, Liang Y, McGaughey GB, Liu M, Miller MD, Moyer G, Munshi V, Perlow-Poehnelt RA, Prasad S, Reid JC, Sanchez R, Torrent M, Vacca JP, Wan BL, Yan Y
J Med Chem (2008), Volume 51, Page 6503
Abstract:
Polymerases:
Topics:
Structure and Structure/Function, Reverse Transcriptase
Status:
new | topics/pols set | partial results | complete | validated |
Results:
Polymerase | Reference | Property | Result | Context |
---|---|---|---|---|
HIV RT | Discovery of 3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5 -chlorobenzonitrile (MK-4965): a potent, orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitor with improved potency against key mutant viruses. | Reverse Transcriptase Activity | Yes |