Snapshot of a DNA polymerase while incorporating two consecutive C5-modified nucleotides.

Abstract:

Functional nucleotides are important in many cutting-edge biomolecular techniques. Often several modifided nucleotides have to be incorporated consecutively. This structural study of KlenTaq DNA polymerase, a truncated form of Thermus aquaticus DNA polymerase, gives first insights how multiple modifications are processed by a DNA polymerase and, therefore, contribute to the understanding of these enzymes in their interplay with artificial substrates.

Polymerases:

Topics:

Nucleotide Incorporation

Status:

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