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Perlow-Poehnelt RA

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Publications:

Title Authors Year Journal
Substituted tetrahydroquinolines as potent allosteric inhibitors of reverse transcriptase and its key mutants. Perlow-Poehnelt RA 2009 Bioorganic & medicinal chemistry letters
The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations. Perlow-Poehnelt RA 2008 Bioorganic & medicinal chemistry letters
Discovery of 3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5 -chlorobenzonitrile (MK-4965): a potent, orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitor with improved potency against key mutant viruses. Perlow-Poehnelt RA 2008 J Med Chem
Increased flexibility enhances misincorporation: temperature effects on nucleotide incorporation opposite a bulky carcinogen-DNA adduct by a Y-family DNA polymerase. Perlow-Poehnelt RA 2007 The Journal of biological chemistry
The spacious active site of a Y-family DNA polymerase facilitates promiscuous nucleotide incorporation opposite a bulky carcinogen-DNA adduct: elucidating the structure-function relationship through experimental and computational approaches. Perlow-Poehnelt RA 2004 The Journal of biological chemistry
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