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San-Félix A

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Publications:

Title Authors Year Journal
N-3 substituted TSAO derivatives as a probe to explore the dimeric interface of HIV-1 reverse transcriptase. San-Félix A Nucleosides, nucleotides & nucleic acids
Selective inhibition of Human Immunodeficiency Virus type 1 (HIV-1) by a novel family of tricyclic nucleosides. San-Félix A 2011 Antiviral research
Dimerization inhibitors of HIV-1 reverse transcriptase, protease and integrase: a single mode of inhibition for the three HIV enzymes? San-Félix A 2006 Antiviral research
TSAO derivatives, inhibitors of HIV-1 reverse transcriptase dimerization: recent progress. San-Félix A 2006 Current pharmaceutical design
TSAO derivatives the first non-peptide inhibitors of HIV-1 RT dimerization. San-Félix A 2005 Antiviral chemistry & chemotherapy
The role of Thr139 in the human immunodeficiency virus type 1 reverse transcriptase sensitivity to (+)-calanolide A. San-Félix A 2005 Molecular pharmacology
TSAO compounds: the comprehensive story of a unique family of HIV-1 specific inhibitors of reverse transcriptase. San-Félix A 2004 Current topics in medicinal chemistry
Structure-activity relationship studies on a novel family of specific HIV-1 reverse transcriptase inhibitors. San-Félix A 2003 Antiviral chemistry & chemotherapy
Site-directed mutagenesis of human immunodeficiency virus type 1 reverse transcriptase at amino acid position 138. San-Félix A 2001 Virology
Identification of a novel family of nucleosides that specifically inhibit HIV-1 reverse transcriptase. San-Félix A 2001 Bioorganic & medicinal chemistry letters
Exploitation of the low fidelity of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and the nucleotide composition bias in the HIV-1 genome to alter the drug resistance development of HIV. San-Félix A 2001 Journal of virology
Identification of a putative binding site for [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine (TSAO) derivatives at the p51-p66 interface of HIV-1 reverse transcriptase. San-Félix A 2001 Journal of medicinal chemistry
Abasic analogues of TSAO-T as the first sugar derivatives that specifically inhibit HIV-1 reverse transcriptase. San-Félix A 1998 Journal of medicinal chemistry
Marked inhibitory activity of non-nucleoside reverse transcriptase inhibitors against human immunodeficiency virus type 1 when combined with (-)2',3'-dideoxy-3'-thiacytidine. San-Félix A 1996 Molecular pharmacology
Synthesis and anti-HIV activity of [AZT]-[TSAO-T] and [AZT]-[HEPT] dimers as potential multifunctional inhibitors of HIV-1 reverse transcriptase. San-Félix A 1995 Journal of medicinal chemistry
Suppression of the breakthrough of human immunodeficiency virus type 1 (HIV-1) in cell culture by thiocarboxanilide derivatives when used individually or in combination with other HIV-1-specific inhibitors (i.e., TSAO derivatives). San-Félix A 1995 Proceedings of the National Academy of Sciences of the United States of America
Human immunodeficiency virus type 1 (HIV-1) strains selected for resistance against the HIV-1-specific [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro- 5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)]-beta-D-pentofurano syl (TSAO) nucleoside analogues retain sensitivity to HIV-1-specific nonnucleoside inhibitors. San-Félix A 1993 Proceedings of the National Academy of Sciences of the United States of America
[2',5'-Bis-O-(tert-butyldimethylsilyl)]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide) (TSAO) derivatives of purine and pyrimidinenucleosides as potent and selective inhibitors of human immunodeficiency virus type 1. San-Félix A 1992 Antimicrobial agents and chemotherapy
Kinetics of inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by the novel HIV-1-specific nucleoside analogue [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5 "- (4"-amino-1",2"-oxathiole-2",2"-dioxide)thymine (TSAO-T). San-Félix A 1992 The Journal of biological chemistry
2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2'-dioxide)pyrimidine (TSAO) nucleoside analogues: highlyselective inhibitors of human immunodeficiency virus type 1 that are targeted at the viral reverse transcriptase. San-Félix A 1992 Proceedings of the National Academy of Sciences of the United States of America
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