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Brenner BG

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Publications:

Title Authors Year Journal
Basis for the Early and Preferential Selection of the E138K Substitution in HIV-1 Reverse Transcriptase with Etravirine. Brenner BG 2013 Antimicrobial agents and chemotherapy
The preferential selection of K65R in HIV-1 subtype C is attenuated by nucleotide polymorphisms at thymidine analogue mutation sites. Brenner BG 2013 The Journal of antimicrobial chemotherapy
Transmission dynamics of the M184V drug resistance mutation in primary HIV infection. Brenner BG 2011 The Journal of antimicrobial chemotherapy
A template-dependent dislocation mechanism potentiates K65R reverse transcriptase mutation development in subtype C variants of HIV-1. Brenner BG 2011 PloS one
Subtype diversity associated with the development of HIV-1 resistance to integrase inhibitors. Brenner BG 2011 Journal of medical virology
Characterization of the E138K resistance mutation in HIV-1 reverse transcriptase conferring susceptibility to etravirine in B and non-B HIV-1 subtypes. Brenner BG 2011 Antimicrobial agents and chemotherapy
Compensation by the E138K mutation in HIV-1 reverse transcriptase for deficits in viral replication capacity and enzyme processivity associated with the M184I/V mutations. Brenner BG 2011 Journal of virology
Factors affecting template usage in the development of K65R resistance in subtype C variants of HIV type-1. Brenner BG 2010 Antiviral chemistry & chemotherapy
Effects of the K65R and K65R/M184V reverse transcriptase mutations in subtype C HIV on enzyme function and drug resistance. Brenner BG 2009 Retrovirology
Signature nucleotide polymorphisms at positions 64 and 65 in reverse transcriptase favor the selection of the K65R resistance mutation in HIV-1 subtype C. Brenner BG 2009 The Journal of infectious diseases
Multidrug-resistant variants of HIV type 1 (HIV-1) can exist in cells as defective quasispecies and be rescued by superinfection with other defective HIV-1 variants. Brenner BG 2009 The Journal of infectious diseases
Human immunodeficiency virus type 1 recombinant reverse transcriptase enzymes containing the G190A and Y181C resistance mutations remain sensitive to etravirine. Brenner BG 2009 Antimicrobial agents and chemotherapy
Apricitabine does not select additional drug resistance mutations in tissue culture in human immunodeficiency virus type 1 variants containing K65R, M184V, or M184V plus thymidine analogue mutations. Brenner BG 2009 Antimicrobial agents and chemotherapy
Template usage is responsible for the preferential acquisition of the K65R reverse transcriptase mutation in subtype C variants of human immunodeficiency virus type 1. Brenner BG 2009 Journal of virology
Near full-length genomic analysis of a novel subtype A1/C recombinant HIV type 1 isolate from Canada. Brenner BG 2008 AIDS research and human retroviruses
Transmission networks of drug resistance acquired in primary/early stage HIV infection. Brenner BG 2008 AIDS (London, England)
Variations in reverse transcriptase and RNase H domain mutations in human immunodeficiency virus type 1 clinical isolates are associated with divergent phenotypic resistance to zidovudine. Brenner BG 2007 Antimicrobial agents and chemotherapy
High prevalence of the K65R mutation in human immunodeficiency virus type 1 subtype C isolates from infected patients in Botswana treated with didanosine-based regimens. Brenner BG 2006 Antimicrobial agents and chemotherapy
HIV-1 subtype C viruses rapidly develop K65R resistance to tenofovir in cell culture. Brenner BG 2006 AIDS (London, England)
Substitutions in the reverse transcriptase and protease genes of HIV-1 subtype B in untreated individuals and patients treated with antiretroviral drugs. Brenner BG 2005 MedGenMed : Medscape general medicine
Changing patterns in the selection of viral mutations among patients receiving nucleoside and nucleotide drug combinations directed against human immunodeficiency virus type 1 reverse transcriptase. Brenner BG 2005 Antimicrobial agents and chemotherapy
Substitutions in the Reverse Transcriptase and Protease Genes of HIV-1 Subtype B in Untreated Individuals and Patients Treated With Antiretroviral Drugs. Brenner BG 2005 Journal of the International AIDS Society
Relationships among various nucleoside resistance-conferring mutations in the reverse transcriptase of HIV-1. Brenner BG 2004 The Journal of antimicrobial chemotherapy
Diminished representation of HIV-1 variants containing select drug resistance-conferring mutations in primary HIV-1 infection. Brenner BG 2004 Journal of acquired immune deficiency syndromes
Variability in the PR and RT genes of HIV-1 isolated from recently infected subjects. Brenner BG 2004 Antiviral chemistry & chemotherapy
Differential maintenance of the M184V substitution in the reverse transcriptase of human immunodeficiency virus type 1 by various nucleoside antiretroviral agents in tissue culture. Brenner BG 2004 Antimicrobial agents and chemotherapy
Persistence of multidrug-resistant HIV-1 in primary infection leading to superinfection. Brenner BG 2004 AIDS (London, England)
Nucleotide and amino acid polymorphisms at drug resistance sites in non-B-subtype variants of human immunodeficiency virus type 1. Brenner BG 2004 Antimicrobial agents and chemotherapy
A V106M mutation in HIV-1 clade C viruses exposed to efavirenz confers cross-resistance to non-nucleoside reverse transcriptase inhibitors. Brenner BG 2003 AIDS (London, England)
Multiple effects of the M184V resistance mutation in the reverse transcriptase of human immunodeficiency virus type 1. Brenner BG 2003 Clinical and diagnostic laboratory immunology
Didanosine, interferon-alfa and ribavirin: a highly synergistic combination with potential activity against HIV-1 and hepatitis C virus. Brenner BG 2003 AIDS (London, England)
Lamivudine can exert a modest antiviral effect against human immunodeficiency virus type 1 containing the M184V mutation. Brenner BG 2003 Antimicrobial agents and chemotherapy
The M184V substitution in human immunodeficiency virus type 1 reverse transcriptase delays the development of resistance to amprenavir and efavirenz in subtype B and C clinical isolates. Brenner BG 2003 Antimicrobial agents and chemotherapy
Pressure of zidovudine accelerates the reversion of lamivudine resistance-conferring M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1. Brenner BG 2002 Antimicrobial agents and chemotherapy
Polymorphisms of cytotoxic T-lymphocyte (CTL) and T-helper epitopes within reverse transcriptase (RT) of HIV-1 subtype C from Ethiopia and Botswana following selection of antiretroviral drug resistance. Brenner BG 2002 Antiviral research
Persistence and fitness of multidrug-resistant human immunodeficiency virus type 1 acquired in primary infection. Brenner BG 2002 Journal of virology
Co-receptor usage and HIV-1 intra-clade C polymorphisms in the protease and reverse transcriptase genes of HIV-1 isolates from Ethiopia and Botswana. Brenner BG 2002 Antiviral therapy
Genetic divergence of human immunodeficiency virus type 1 Ethiopian clade C reverse transcriptase (RT) and rapid development of resistance against nonnucleoside inhibitors of RT. Brenner BG 2002 Antimicrobial agents and chemotherapy
Resistance to antiretroviral drugs in patients with primary HIV-1 infection. Investigators of the Quebec Primary Infection Study. Brenner BG 2000 International journal of antimicrobial agents
Prevalence of HIV-1 resistant to antiretroviral drugs in 81 individuals newly infected by sexual contact or injecting drug use. Investigators of the Quebec Primary Infection Study. Brenner BG 2000 AIDS (London, England)

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