Co-receptor usage and HIV-1 intra-clade C polymorphisms in the protease and reverse transcriptase genes of HIV-1 isolates from Ethiopia and Botswana.

Abstract:

Knowledge of baseline amino acid substitutions arising at certain ...
Knowledge of baseline amino acid substitutions arising at certain critical positions in the HIV-1 non-clade-B protease (PR) and reverse transcriptase (RT) enzymes may yield important information with regard to anticipation of responses to antiretroviral treatment and development of drug resistance. We have compared RT and PR sequences within HIV-1 clade C strains isolated from 14 treatment-naive patients originating from Ethiopia and Botswana with those of PR and RT consensus subtype B RT and PR sequences. Variations in the frequency of natural polymorphisms were observed in clade C isolates at drug-resistance sites. Intra-clade C divergence among mutations within PR was statistically significant while that within RT was not. Only a M361 substitution in PR was shared among almost all isolates from Ethiopia and Botswana. Analysis of the co-receptor usage of clade C isolates from Ethiopia and Botswana supports the known preferential usage of the CCR5 co-receptor by HIV-1 clade C strains. No Ethiopian or Botswanian isolates exclusively used the CXCR4 co-receptor, which is consistent with most data obtained with HIV-1 clade B isolates.

Polymerases:

Topics:

Status:

new topics/pols set partial results complete validated

Results:

No results available for this paper.

Entry validated by:

Using Polbase tables:

Sorting:

Tables may be sorted by clicking on any of the column titles. A second click reverses the sort order. <Ctrl> + click on the column titles to sort by more than one column (e.g. family then name).

Filtering:

It is also possible to filter the table by typing into the search box above the table. This will instantly hide lines from the table that do not contain your search text.