A V106M mutation in HIV-1 clade C viruses exposed to efavirenz confers cross-resistance to non-nucleoside reverse transcriptase inhibitors.

Brenner BG, Turner D, Oliveira M, Moisi DD, Detorio M, Carobene M, Marlink RG, Schapiro J, Roger M, Wainberg MA
AIDS (London, England) (2003), Volume 17, Page F1
PubMed entry Publisher's site

Abstract:

We have shown that HIV-1 clade C variants contain a valine codon 106 ...
We have shown that HIV-1 clade C variants contain a valine codon 106 polymorphism (GTG) that facilitates a V106M transition (GTG<--ATG) after selection with efavirenz (EFV). This study evaluates the prevalence of V106 (GTG) and 106M (ATG) codons in clinical isolates as well as the effects of V106M on resistance to non-nucleoside reverse transcriptase inhibitors (NNRTI).

Polymerases:

HIV RT V106M,HIV RT V106M,HIV RT V106M,HIV RT

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