Identification of low-molecular weight inhibitors of HIV-1 reverse transcriptase using a cell-based high-throughput screening system. |
Jegede O, Khodyakova A, Chernov M, Weber J, Menéndez-Arias L, Gudkov A, Quiñones-Mateu ME |
2011 |
Clinical relevance of substitutions in the connection subdomain and RNase H domain of HIV-1 reverse transcriptase from a cohort of antiretroviral treatment-naïve patients. |
Hachiya A, Shimane K, Sarafianos SG, Kodama EN, Sakagami Y, Negishi F, Koizumi H, Gatanaga H, Matsuoka M, Takiguchi M, Oka S |
2009 |
In vitro selection and molecular characterization of human immunodeficiency virus type 1 with reduced sensitivity to 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). |
Foli A, Sogocio KM, Anderson B, Kavlick M, Saville MW, Wainberg MA, Gu Z, Cherrington JM, Mitsuya H, Yarchoan R |
1996 |
Inhibition of human immunodeficiency virus type 1 wild-type and mutant reverse transcriptases by the phenyl ethyl thiazolyl thiourea derivatives trovirdine and MSC-127. |
Zhang H, Vrang L, Bäckbro K, Lind P, Sahlberg C, Unge T, Oberg B |
1995 |
Penciclovir and pathogenesis phenotypes of drug-resistant Herpes simplex virus mutants. |
Pelosi E, Mulamba GB, Coen DM |
1998 |
Genotypic characterization of herpes simplex virus DNA polymerase UL42 processivity factor. |
Burrel S, Aït-Arkoub Z, Agut H, Boutolleau D |
2012 |
Slow binding-tight binding interaction between benzimidazol-2-one inhibitors and HIV-1 reverse transcriptase containing the lysine 103 to asparagine mutation. |
Samuele A, Crespan E, Vitellaro S, Monforte AM, Logoteta P, Chimirri A, Maga G |
2010 |
The implications of resistance to antiviral agents for herpesvirus drug targets and drug therapy. |
Coen DM |
1991 |
Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. |
Suzuki M, Okuda T, Shiraki K |
2006 |
Novel L-lyxo and 5'-deoxy-5'-modified TSAO-T analogs: synthesis and anti-HIV-1 activity. |
Ingate S, De Clercq E, Balzarini J, Camarasa MJ |
1996 |
Novel DNA polymerase mutations conferring cytomegalovirus resistance: input of BAC-recombinant phenotyping and 3D model. |
Hantz S, Cotin S, Borst E, Couvreux A, Salmier A, Garrigue I, Merville P, Mengelle C, Attal M, Messerle M, Alain S |
2013 |
Non-nucleoside HIV-1 reverse transcriptase inhibitors di-halo-indolyl aryl sulfones achieve tight binding to drug-resistant mutants by targeting the enzyme-substrate complex. |
Samuele A, Kataropoulou A, Viola M, Zanoli S, La Regina G, Piscitelli F, Silvestri R, Maga G |
2009 |
NNRTI-selected mutations at codon 190 of human immunodeficiency virus type 1 reverse transcriptase decrease susceptibility to stavudine and zidovudine. |
Paolucci S, Baldanti F, Campanini G, Cancio R, Belfiore A, Maga G, Gerna G |
2007 |
Polymorphisms of cytotoxic T-lymphocyte (CTL) and T-helper epitopes within reverse transcriptase (RT) of HIV-1 subtype C from Ethiopia and Botswana following selection of antiretroviral drug resistance. |
Loemba H, Brenner BG, Parniak MA, Ma'ayan S, Spira B, Moisi DD, Oliveira M, Detorio M, Essex M, Wainberg MA |
2002 |
2-(2,6-Dihalophenyl)-3-(pyrimidin-2-yl)-1,3-thiazolidin-4-ones as non-nucleoside HIV-1 reverse transcriptase inhibitors. |
Rao A, Balzarini J, Carbone A, Chimirri A, De Clercq E, Monforte AM, Monforte P, Pannecouque C, Zappalà M |
2004 |
Resistance mutations selected in vivo under therapy with anti-HIV drug HBY 097 differ from resistance pattern selected in vitro. |
Rübsamen-Waigmann H, Huguenel E, Shah A, Paessens A, Ruoff HJ, von Briesen H, Immelmann A, Dietrich U, Wainberg MA |
1999 |
Therapeutic strategies towards HIV-1 infection in macrophages. |
Perno CF, Svicher V, Schols D, Pollicita M, Balzarini J, Aquaro S |
2006 |
Early nucleoside reverse transcriptase inhibitors for the treatment of HIV: a brief history of stavudine (D4T) and its comparison with other dideoxynucleosides. |
Martin JC, Hitchcock MJ, De Clercq E, Prusoff WH |
2010 |
Activity of various thiocarboxanilide derivatives against wild-type and several mutant human immunodeficiency virus type 1 strains. |
Balzarini J, Brouwer WG, Felauer EE, De Clercq E, Karlsson A |
1995 |
2-Chloro-3-pyridin-3-yl-5,6,7,8-tetrahydroindolizine-1-carboxamide (CMV423), a new lead compound for the treatment of human cytomegalovirus infections. |
Snoeck R, Andrei G, Bodaghi B, Lagneaux L, Daelemans D, De Clercq E, Neyts J, Schols D, Naesens L, Michelson S, Bron D, Otto MJ, Bousseau A, Nemecek C, Roy C |
2002 |
In vitro evaluation of the effect of temporary removal of HIV drug pressure. |
Witvrouw M, Pannecouque C, Desmyter J, De Clercq E, Andries K |
2000 |
Inhibitory effect of glycyrrhizin on the in vitro infectivity and cytopathic activity of the human immunodeficiency virus [HIV (HTLV-III/LAV)]. |
Ito M, Nakashima H, Baba M, Pauwels R, De Clercq E, Shigeta S, Yamamoto N |
1987 |
Selective inhibition of Human Immunodeficiency Virus type 1 (HIV-1) by a novel family of tricyclic nucleosides. |
Bonache MC, Cordeiro A, Quesada E, Vanstreels E, Daelemans D, Camarasa MJ, Balzarini J, San-Félix A |
2011 |
Comparative evaluation of the activity of antivirals towards feline immunodeficiency virus in different cell culture systems. |
van der Meer FJ, Schuurman NM, Balzarini J, Egberink HF |
2007 |
Macrophages and HIV infection: therapeutical approaches toward this strategic virus reservoir. |
Aquaro S, Caliò R, Balzarini J, Bellocchi MC, Garaci E, Perno CF |
2002 |
Antiviral drug discovery and development: where chemistry meets with biomedicine. |
De Clercq E |
2005 |
Ribavirin and mycophenolic acid markedly potentiate the anti-hepatitis B virus activity of entecavir. |
Ying C, Colonno R, De Clercq E, Neyts J |
2007 |
In search of a selective therapy of viral infections. |
De Clercq E |
2010 |
Antiviral properties of new arylsulfone derivatives with activity against human betaherpesviruses. |
Naesens L, Stephens CE, Andrei G, Loregian A, De Bolle L, Snoeck R, Sowell JW, De Clercq E |
2006 |
Therapy and short-term prophylaxis of poxvirus infections: historical background and perspectives. |
Neyts J, De Clercq E |
2003 |
The anti-herpesvirus activity of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl)-cycloprop-1'-yl]methyl]guanine is markedly potentiated by the immunosuppressive agent mycophenolate mofetil. |
Neyts J, De Clercq E |
2001 |
Suramin in the treatment of AIDS: mechanism of action. |
De Clercq E |
1987 |
Ribavirin and mycophenolic acid potentiate the activity of guanine- and diaminopurine-based nucleoside analogues against hepatitis B virus. |
Ying C, De Clercq E, Neyts J |
2000 |
New arylpyrido-diazepine and -thiodiazepine derivatives are potent and highly selective HIV-1 inhibitors targeted at the reverse transcriptase. |
Bellarosa D, Antonelli G, Bambacioni F, Giannotti D, Viti G, Nannicini R, Giachetti A, Dianzani F, Witvrouw M, Pauwels R, Desmyter J, De Clercq E |
1996 |
The role of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection. |
De Clercq E |
1998 |
Antiviral activity of the bicyclam derivative JM3100 against drug-resistant strains of human immunodeficiency virus type 1. |
Esté JA, De Vreese K, Witvrouw M, Schmit JC, Vandamme AM, Anné J, Desmyter J, Henson GW, Bridger G, De Clercq E |
1996 |
Dimerization inhibitors of HIV-1 reverse transcriptase, protease and integrase: a single mode of inhibition for the three HIV enzymes? |
Camarasa MJ, Velázquez S, San-Félix A, Pérez-Pérez MJ, Gago F |
2006 |
Phosphorylation of nucleoside analogs by equine herpesvirus type 1 pyrimidine deoxyribonucleoside kinase. |
Kit S, Ichimura H, De Clercq E |
1987 |
In vitro selection of drug-resistant varicella-zoster virus (VZV) mutants (OKA strain): differences between acyclovir and penciclovir? |
Andrei G, De Clercq E, Snoeck R |
2004 |